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41.
Dinghai Xu 《统计学通讯:模拟与计算》2013,42(7):1403-1421
This article investigates an efficient estimation method for a class of switching regressions based on the characteristic function (CF). We show that with the exponential weighting function, the CF-based estimator can be achieved from minimizing a closed form distance measure. Due to the availability of the analytical structure of the asymptotic covariance, an iterative estimation procedure is developed involving the minimization of a precision measure of the asymptotic covariance matrix. Numerical examples are illustrated via a set of Monte Carlo experiments examining the implementation, finite sample property and the efficiency of the proposed estimator. 相似文献
42.
Przystalski and Krajewski (2007) proposed the restricted backfitting (RBCF) estimator and restricted Speckman (RSPC) estimator for the treatment effects in a partially linear model when some additional exact linear restrictions are assumed to hold. In this article, we introduce the preliminary test backfitting (PTBCF) estimator and preliminary test Speckman (PTSPC) estimator when the validity of the restrictions is suspected. Performances of the proposed estimators are examined with respect to the mean squared error (MSE) criterion. In addition, numerical behaviors of the proposed estimators are illustrated and compared via a Monte Carlo simulation study. 相似文献
43.
We propose a semiparametric approach for the analysis of case–control genome-wide association study. Parametric components are used to model both the conditional distribution of the case status given the covariates and the distribution of genotype counts, whereas the distribution of the covariates are modelled nonparametrically. This yields a direct and joint modelling of the case status, covariates and genotype counts, and gives a better understanding of the disease mechanism and results in more reliable conclusions. Side information, such as the disease prevalence, can be conveniently incorporated into the model by an empirical likelihood approach and leads to more efficient estimates and a powerful test in the detection of disease-associated SNPs. Profiling is used to eliminate a nuisance nonparametric component, and the resulting profile empirical likelihood estimates are shown to be consistent and asymptotically normal. For the hypothesis test on disease association, we apply the approximate Bayes factor (ABF) which is computationally simple and most desirable in genome-wide association studies where hundreds of thousands to a million genetic markers are tested. We treat the approximate Bayes factor as a hybrid Bayes factor which replaces the full data by the maximum likelihood estimates of the parameters of interest in the full model and derive it under a general setting. The deviation from Hardy–Weinberg Equilibrium (HWE) is also taken into account and the ABF for HWE using cases is shown to provide evidence of association between a disease and a genetic marker. Simulation studies and an application are further provided to illustrate the utility of the proposed methodology. 相似文献
44.
Fei Xu 《Serials Review》2013,39(4):235-241
AbstractDuring 2009, the Hilton M. Briggs Library, South Dakota State University, went live with MetaLib, a federated search engine from Ex Libris. This paper presents the implementation process, addresses resource accessibility issues, and suggests a number of resources that can be consulted about these issues. Readers can apply similar strategies to projects involving federated search systems, as many implementation projects involve the same basic considerations presented here. The author did not find any studies specifically focused on configurations of MetaLib resources, so this content should be singularly useful. 相似文献
45.
The Cox proportional hazards (PH) regression model has been widely used to analyze survival data in clinical trials and observational studies. In addition to estimating the main treatment or exposure group effect, it is common to adjust for additional covariates using the Cox model. It is well known that violation of the PH assumption can lead to estimates that are biased and difficult to interpret, and model checking has become a routine procedure. However, such checking might focus on the primary group comparisons, and the assumption can still be violated when adjusting for many of the potential covariates. We study the effect of violation of the PH assumption of the covariates on the estimation of the main group effect in the Cox model. The results are summarized in terms of the bias and the coverage properties of the confidence intervals. Overall in randomized clinical trials, the bias caused by misspecifying the PH assumption on the covariates is no more than 15% in absolute value regardless of sample size. In observational studies where the covariates are likely correlated with the group variable, however, the bias can be very severe. The coverage properties largely depend on sample size, as expected, as bias becomes dominating with increasing sample size. These findings should serve as cautionary notes when adjusting for potential confounders in observational studies, as the violation of PH assumption on the confounders can lead to erroneous results. 相似文献
46.
AbstractIn this paper, assuming that the error terms follow a multivariate t distribution, we derive the exact formula for the predictive mean squared error (PMSE) of two different types of pretest estimators. It is shown analytically that one of the pretest estimator dominates the SR estimator if a critical value of the pretest is chosen appropriately. Also, we compare the PMSE of the pretest estimators with the MMSE, AMMSE, SR and PSR estimators by numerical evaluations. Our results show that the pretest estimators dominate the OLS estimator for all combinations when the degrees of freedom is not more than 5. 相似文献
47.
This article is concerned with the parameter estimation in linear regression model when it is suspected that the regression coefficients are the subspace of the equality restrictions. The objective of this article is to introduce the preliminary test almost unbiased Liu estimators (PTAULE) based on the Wald (W), the likelihood ratio (LR), and the Lagrangian multiplier (LM) tests and compare the proposed estimators in the sense of the quadratic bias and mean square error (MSE) criterion. 相似文献
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本文结合我国上市公司所面临的内部治理机制特点及外部治理环境,从大股东行为的视角对公司现金持有量的影响因素进行实证分析。在加入年度控制变量、行业控制变量和公司财务特征控制变量后,对三项反映大股东行为特征的因素,即大股东持股比例、大股东属性和制度环境因素对公司现金持有量的影响进行了检验。结果表明,第一大股东持股比例较高的公司持有较多的现金,大股东的高持股比例是其占用企业资金侵占中小股东利益的基础。与国有企业相比,民营企业因遭受较强的外部融资约束而持有较高水平的现金。此外,制度环境的发展程度与公司现金持有水平正相关,表明制度环境较好地区的公司持有较多的现金。 相似文献