被神经性毒剂染毒的蛋白IgG中有机磷加合物的研究

本文对IgG与神经性毒剂的加合物进行了研究。用过量的神经性毒剂(沙林、梭曼、VX、环沙林)对IgG(人、大鼠IgG)进行体外染毒,用胰蛋白酶进行酶解,所得样品用Q Exactive LC-MS/MS方法进行分析鉴定,发现了IgG与神经性毒剂的加合物肽段。其中,从人的IgG中发现了4个被标记的肽段,从大鼠的IgG中发现了1个被标记的肽段,另外,还从肽段的二级谱图中发现了酪氨酸加合物的特征离子碎片。本文首次发现了被神经性毒剂标记的IgG肽段,进而说明IgG是鉴定神经性毒剂中毒的一类重要的标记蛋白。     

花岗岩储层损害机理及保护技术研究

花岗岩储层由于岩性、物性、孔隙结构和敏感性矿物特征与常规储层有一定的差异，所以其损害机理也与常规储层不尽相同。本次研究利用扫描电镜、铸体薄片等手段，系统分析了花岗岩储层的损害机理，并对其有效的储层保护措施进行了探讨。研究结果表明：花岗岩储层主要的损害机理为固相侵入、应力敏感性损害和水锁损害，“五敏”损害中水/盐敏、碱敏损害较弱，主要为酸敏和速敏损害。研究认为欠平衡钻井技术是开发花岗岩储层的最佳选择，将欠平衡钻井与非直井工艺相结合可穿越储层中多条裂缝，获得更佳的产能；低压屏蔽暂堵技术虽然难以解决储层中宏观缝、大缝的封堵问题，但可以有效封堵储层中小于50μm的裂缝，使部分产能得到保护     

Let Me Go: The Influences of Crawling Experience and Temperament on the Development of Anger Expression

Infants’ emerging ability to move independently by crawling is associated with changes in multiple domains, including an increase in expressions of anger in situations that block infants’ goals, but it is unknown whether increased anger is specifically because of experience with being able to move autonomously or simply related to age. To examine the influence of locomotion on developmental change in anger, infants’ (N = 20) anger expressions during an arm restraint procedure were observed longitudinally at a precrawling baseline assessment and 2 and 6 weeks after the onset of crawling. Infant age at each crawling stage was unrelated to the frequency of anger expressed in response to arm restraint. At 6 weeks postcrawling onset, infants whose mothers rated them as temperamentally higher in distress to limitations, compared with those rated lower, showed a greater increase in the frequency of anger expressed during the arm restraint relative to earlier assessments and took longer to reduce the frequency of anger expressed when no longer restrained. Findings suggest that experience with autonomous crawling has an effect on anger expression, independent of age, and that a temperamental tendency to become distressed by limitations may exacerbate the effect of crawling on anger expression.     

Too Scared or Too Capable? Why Do College Students Stay Away from the H1N1 Vaccine?

Although college students were among the populations that had the highest frequency of infection for H1N1 influenza, only 8% of them received H1N1 vaccine this past flu season nationwide. During the peak of this pandemic, information about H1N1 vaccine was widely available. However, knowledge test and behavioral data indicated that most college students were not equipped with basic facts about H1N1 and the H1N1 vaccine. To investigate socio‐psychological factors that might have deterred this high‐risk population from learning about and getting the H1N1 vaccine, this study tested the utility of a risk information seeking model in addressing this health communication problem. Data collected from an online survey of 371 college students showed that respondents seemed to overestimate how much they knew about the vaccine. Risk information seeking, however, positively influenced their intentions to get the vaccine. Results suggested that to communicate effectively to this population, it is important to emphasize the difference between perceived knowledge and actual knowledge, monitor emotional responses to potential risks, and promote getting flu vaccination as a socially desirable behavior.     

Hypothesis Testing in a Rayleigh Diffusion Model

Applying the large and moderate deviations for the log-likelihood ratio of the Rayleigh diffusion model, we give the negative regions in testing Rayleigh diffusion model and obtain the decay rates of the error probabilities.     

朝阳民间刺绣：遗留在深山的“珍珠”

一项项民间技艺如一颗颗美丽的珍珠,散落在乡野间的每个角落,经过岁月的打磨,散发出温润的光泽.而作为非遗工作者,就是那些采撷珠宝的人,要将它们一一串联,使其绽放更为动人的夺目光彩.2013年的初夏,我和同事们来到朝阳,找寻那颗遗留在深山里的珍珠——朝阳民间刺绣.     

国家参与全球治理的理论与指数化

在全球治理中,社会逻辑是显性逻辑,国家逻辑和资本逻辑则是隐性逻辑.社会逻辑在全球治理理论中占有核心位置,而国家逻辑却在全球治理实践中处于主导地位.鉴于国家在全球治理中的重要作用,笔者提出一种共和主义的国家参与全球治理观.指数构建对国家参与全球治理的实践有重要的推动作用.“国家参与全球治理指数”(SPIGG)项目组提出了一个完整的指标体系,并就这一指数的数据采集、数据标准化、权重设置和计量模型等一系列问题进行了深入讨论.SPIGG指数的创设可以有助于推动全球治理理论的进一步发展,也有助于把中国知识传递到全球治理的实践中去.     

注蒸汽水平井井筒内参数计算新模型

注入蒸汽在水平井筒内流动时，蒸汽沿着水平段的质量流量越来越小，且加速度压降不等于零，导致蒸汽的物性参数发生变化，而蒸汽物性对井筒内蒸汽的沿程参数分布有较大影响。依据质量守恒和能量守恒，建立了注入蒸汽干度沿水平段的变化方程，利用动量守恒原理，推导了沿水平井筒的蒸汽干度分布和压力分布计算公式，构建了摩擦力做功、湿蒸汽混合物密度、水平段吸汽量和井筒与油层之间的热传递计算模型，模型同时考虑了变质量流与蒸汽PVT参数的变化对计算结果的影响，采用按压力增量迭代的计算方法对模型进行求解。实例的模型计算结果与油藏数值模拟结果对比表明，新模型具有较高的计算精度。     

Evaluation of scheduling strategies for a dynamic job shop in a tool-shared,flexible manufacturing environment

A two-phase approach is used to examine the impact of job scheduling rules and tool selection policies for a dynamic job shop system in a tool-shared, flexible manufacturing environment. The first phase develops a generalized simulation model and analyses 'simple' job scheduling rules and tool selection policies under various operating scenarios. The results from this investigation are then used to develop and analyse various bi-criteria rules in the second phase of this study. The results show that the scheduling rules have the most significant impact on system performance, particularly at high shop load levels. Tool selection policies affect some of the performance measures, most notably, proportion of tardy jobs, to a lesser degree. Higher machine utilizations can be obtained at higher tool duplication levels but at the expense of increased tooling costs and lower tool utilization. The results also show that using different processing time distributions may have a significant impact on shop performance.     

从新视角看中国近代史的基本线索

本文从新的视角重新梳理了中国近代史的基本线索,即把中国近代史放进整个世界近代历史发展进程和中华民族形成史中,以此为视角,认为中国近代史有三条基本线索,即中国近代史是中华民族反对帝国主义,争取民族独立和解放的过程;中华民族在各层次上实现近代转型和现代化的过程;中华民族走向自觉联合的过程。