Proteins' promise--progress and challenges in ovarian cancer proteomics

Ovarian cancer is the leading cause of gynaecological cancer death. The mortality rate of ovarian cancer could be greatly decreased if there were a screening test which was able to detect the disease at an early stage, resulting in an increased probability of cure. The most promising prospect for the early detection of ovarian cancer comes from the rapidly advancing field of clinical proteomics. An increasing number of reports on the potential clinical application of proteomics research for early detection as well as risk assessment and management of ovarian cancer are being published. Although the research is very promising, major technical challenges are still preventing new discoveries in ovarian cancer proteomics from being translated into clinical practice.     

The Experience-Earnings Profile: Productivity-Augmenting or Purely Contractual? Evidence from the UK

We test the human capital interpretation of the experience-earnings profile. Does the upward sloping portion of the experience-earnings profile reflect on-the-job training which in turn causes the experience-productivity profile to slope upwards, or do purely contractual factors determine the nature of life-cycle earnings. Herein, we provide additional evidence on the relationship between productivity and earnings by examining earnings differentials in the UK academic labor market for economists. Using a test first suggested by Mincer, we find that the empirical results are consistent with human capital theory. We find that, although the positive relationship between earnings and experience persists when individual productivity measures are included in the salary equations for lecturers and senior lecturers, the positive relationship becomes statistically insignificant when the same productivity measures are included in the salary equations for professors. For lecturers and senior lecturers, the experience-salary profile properly reflects the structure of the national pay scale rather than variations in individual research productivity. At the professor level, where individual salaries are not determined by a pay scale, the data support the human capital explanation of the positive experience-earnings profile.

Earnings Differentials of Seafarers

I investigate the earnings differentials among union and nonunion seafarers, across seafarer occupations, and with respective to other transport operatives. The empirical results suggest that the union and nonunion weekly earnings of captains/mates are comparable, and the union earnings gap for sailors/deckhands is positive. The union (nonunion) weekly earnings of captains/mates are 14.7 (30.5) percent greater than those of sailors/deckhands; the union weekly earnings of captains/mates (sailors/deckhands) are 12.6% greater (9.5% less) than those of truck drivers; and the nonunion weekly earnings of captains/mates (sailors/deckhands) are 33.0% greater (6.2% less) than those of truck drivers. The sailor/deckhand and truck driver earnings differentials are contrary to the general belief that the earnings of truck drivers are less than those of other operative occupations involved in transporting intermodal cargo.

'The grit in the oyster': Community development workers in a modernizing local authority

This article offers a brief overview of the challenges facingUK local authorities, including the need to enhance public participationin decision making and service delivery, improve service performanceand increase partnership working. It explores the potentialcontribution of community development work to meeting thesechallenges, drawing on a case study of one UK county council.The essential tensions and conflicts in the role of communitydevelopment workers in a local authority are highlighted, showinghow the modernization process introduced by the New Labour governmentis adding further layers of complexity and ambiguity.     

Personal income taxation under mobility, exogenous and endogenous welfare weights, and asymmetric information

This paper analyses how governments should tax labour income accruing to a group of highly skilled and geographically mobile individuals who divide their time or career between several jurisdictions. The analysis differs from previous models on migration and taxation by addressing optimal regulation when agents work for several principals. Optimal taxation is developed for social welfare functions with exogenous and endogenous welfare weights. Marginal income taxes are applied for screening purposes, and the rates are lower with endogenous than with exogenous welfare weights. Received: 22 January 1998/Accepted: 3 July 1999)