Caloric restriction in trans

Caloric (or dietary) restriction (CR) is the most potent, robust, and reproducible known means of extending longevity and decreasing morbidity in laboratory mammals. Two of the major questions faced by researchers in this field are the applicability to humans and the biochemical mechanism(s) involved in the actions of CR. Studies in nonhuman primates are beginning to address the former; studies in phylogenetically lower organisms such as yeast and Drosophila are beginning to address the latter. de Cabo and colleagues now provide evidence that some aspects of CR can be reproduced in mammalian tissue culture cells exposed to sera from rats and monkeys subjected to CR. This work presents the initial development of a new model with which to approach mechanistic studies of CR and provides a new form of direct evidence that CR exerts at least some of its effects in trans.     

Structure-(Dys)function relationships in mitochondrial electron transport chain complex II?

It has been postulated that mitochondrially derived reactive oxygen species (ROS) play a major causative role in aging processes. The primary sources of these oxidants are believed to be complexes I and III of the electron transport chain, with little evidence supporting oxidant formation at complex II (succinate dehydrogenase). Mutation of a complex II protein has, however, been shown to cause increased oxidative stress and decreased life expectancy in the Caenorhabditis elegans mutant mev-1. A recent study by Yankovskaya and colleagues, in which the structure of Escherichia coli succinate dehydrogenase was determined, provides an explanation for these observations. Furthermore, these results suggest possible mechanisms by which electron leakage might occur at this site in the aged organism.     

The quality of life in Australia

This paper outlines a long term project on the quality of life in Australia and presents some initial survey data. The long term project is intended (1) to find which domains of life most affect the perceived well-being of Australians and the values/satisfactions people wish to achieve in these domains (2) to propose policy programs designed to enhance satisfaction with particular domains and (3) to assess the political feasibility of proposed programs. Policy programs intended to enhance satisfaction are termed positive welfare programs to distinguish them from conventional compensatory welfare programs. The survey data analysed here (national sample, N=679) deal with the satisfactions and dissatisfactions of Australians, the correlates of perceived well-being and the links between domains and values. Perceived well-being is measured by Andrews and Withey's Life-as-a-whole index and Bradburn's Affect Balance scale. Satisfactions are measured on a 9 point modified version of Andrews and Withey's delighted-terrible scale. Readers familiar with American, British and Canadian findings will find the results reported here broadly similar. However, the linkage between people's sociological characteristics and their satisfaction levels appears to be exceptionally weak in Australia, which tends to confirm the view that Australia is a comparatively unstratified society.     

Ever since gompertz

In 1825 British actuary Benjamin Gompertz made a simple but important observation that a law of geometrical progression pervades large portions of different tables of mortality for humans. The simple formula he derived describing the exponential rise in death rates between sexual maturity and old age is commonly referred to as the Gompertz equation—a formula that remains a valuable tool in demography and in other scientific disciplines. Gompertz’s observation of a mathematical regularity in the life table led him to believe in the presence of a law of mortality that explained why common age patterns of death exist. This law of mortality has captured the attention of scientists for the past 170 years because it was the first among what are now several reliable empirical tools for describing the dying-out process of many living organisms during a significant portion of their life spans. In this paper we review the literature on Gompertz’slaw of mortality and discuss the importance of his observations and insights in light of research on aging that has taken place since then.     

Legal standards for evaluation research: A reply to Smith

Smith (1981), asserting that not all evaluative studies require the same degree of evidence for decision-making, suggests a legal paradigm for determining how much certainty is necessary for informed decision-making. Specifically, he argues for the use of three levels of certainty, i.e., suggestive, preponderant, or conclusive evidence, modeled after the legal standards of proof. Unfortunately, such an approach is untenable for several reasons. Smith's suggestion that decision-makers adopt legal terminology, for example, is really a recommendation of form rather than substance and, furthermore, his analogy from the law to the evaluation context is based upon a misunderstanding of the trial process. These and other problems with Smith's suggestions are discussed.     

Social research and social policy: The theoretical connection

Thoughtful scholars have discussed the complex nature of the social research-social policy relationship, and yet many persons continue to plan, conduct, interepret, and fund social research as if they expected it to generate facts that have simple effects on policy. This paper argues that such expectations reflect two, untenable assumptions:Simple positivism andfactual efficacy. These assumptions are reviewed, and a more defensible model for the research-policy relationship is proposed based onplausible theory. Implications for the latter model are then explored. The holder of a Ph.D. in social psychology from the University of Michigan, his professional interests center upon role theory, the study of teaching, social decision-making, and relationships among social research, theory, and policy impact.     

The identification and assessment of political risk in the international environment

Investment decisions are based on a risk/return analysis. The author of this paper asks the basic question ‘Where do politics come in to this analysis?’ In the first part of the article he considers why companies expose themselves to political risk. Next section is concerned with identifying those factors of special importance internationally. The final part of the paper focuses on what alternative policies can be pursued in order to minimize exposure to political risks.     

Optimal Estimating Equations with Applications to Insect Development Times

This paper proposes a general method of estimation when a function of data and parameters is to be modelled, which is most efficient in a certain sense. It is applied to the following situation. If X(t) is the temperature at time t, the time Y taken for an insect to complete a stage of growth is assumed to satisfy the model.     

Psychotherapy with the Father-Absent Military Family

Defense department regulation changes concerning military dependents have had a marked impact on a large number of service families. One outcome is a specific fractured family—father-absent military family—which has unique characteristics and distinctive problems. In addition to explicit features of military families in general, dynamics of the father-absent fragment are discussed. A psychotherapy strategy is also presented which has been shown to be of value in promoting continued growth in the father-absent military family     

Quadratic programming applications

Although quadratic programming (QP) is often studied as a methodology by decision scientists, little emphasis seems to be given to the type of decision science problems that can be so modeled. This paper reviews and extends some of the applied and methodological areas where QP is applicable, discussing and illustrating the characteristics and aspects of the accompanying solutions. Some of the methodological areas amenable include regression analysis, decision analysis, and quadratic approximations to generally complex functions. In the functional management areas, QP is applicable to problems in economics, such as demand-supply response and enterprise selection. In finance, it is used in portfolio analysis; in agriculture, in crop selection. Both the methodological and functional applications of QP are reviewed. Potential new applications of QP are suggested.