广深"双城"联动打造世界级创新平台战略

广深"双城"联动要始终坚持创新在发展全局中的核心地位和战略支撑作用,紧紧围绕粤港澳大湾区建设"世界级创新平台"发展目标,牢牢把握集聚和开放两个核心要义,着力构建高质量的科技创新供给、区域协同创新和科技转化服务三大支撑体系,不断强化广深"双城"联动在国际科技创新中心建设中的支撑引领、整合协同、开放门户和辐射带动等四个方面功用.     

Comparison of robust tests for genetic association analysis incorporating uncertain genotype

Genome-wide association studies are effective in investigating the loci related with complex diseases. Sometimes, the genotype is not exactly decoded and only genotype probability is obtained. In this case, F-test based on imputed genotype is usually used for the association analysis. Simulations show that existing methods such as the dosage test have poor performance when the genetic model is misspecified. In this study, we develop a robust test to detect the association of a disease and genetic loci while the genotype is uncertain and the genetic model is unknown.     

Designing cancer immunotherapy trials with delayed treatment effect using maximin efficiency robust statistics

The indirect mechanism of action of immunotherapy causes a delayed treatment effect, producing delayed separation of survival curves between the treatment groups, and violates the proportional hazards assumption. Therefore using the log‐rank test in immunotherapy trial design could result in a severe loss efficiency. Although few statistical methods are available for immunotherapy trial design that incorporates a delayed treatment effect, recently, Ye and Yu proposed the use of a maximin efficiency robust test (MERT) for the trial design. The MERT is a weighted log‐rank test that puts less weight on early events and full weight after the delayed period. However, the weight function of the MERT involves an unknown function that has to be estimated from historical data. Here, for simplicity, we propose the use of an approximated maximin test, the V₀ test, which is the sum of the log‐rank test for the full data set and the log‐rank test for the data beyond the lag time point. The V₀ test fully uses the trial data and is more efficient than the log‐rank test when lag exits with relatively little efficiency loss when no lag exists. The sample size formula for the V₀ test is derived. Simulations are conducted to compare the performance of the V₀ test to the existing tests. A real trial is used to illustrate cancer immunotherapy trial design with delayed treatment effect.     

Bayesian regression on non-parametric mixed-effect models with shape-restricted Bernstein polynomials

We develop a Bayesian estimation method to non-parametric mixed-effect models under shape-constrains. The approach uses a hierarchical Bayesian framework and characterizations of shape-constrained Bernstein polynomials (BPs). We employ Markov chain Monte Carlo methods for model fitting, using a truncated normal distribution as the prior for the coefficients of BPs to ensure the desired shape constraints. The small sample properties of the Bayesian shape-constrained estimators across a range of functions are provided via simulation studies. Two real data analysis are given to illustrate the application of the proposed method.     

基于CAI模式的调查数据质量控制

计算机辅助调查(CAI)改变了传统纸笔调查的数据收集过程,将数据质量控制提前到调查之前和调查过程中.丰富的并行数据的采集和应用极大地扩展了质量控制的方法,提高了数据质量控制的时效性和有效性.文章着重分析CAI模式下质量控制的方法及其对数据质量改善的作用.     

论经济合作对欧盟边境制度的促进

第二次世界大战后,法、德和平解决了长期困扰两国关系的萨尔问题,开创了以经济合作为前提解决领土纠纷的先例,走出了两国历史中冲突与战争恶性循环的怪圈。其后,欧共体成员国在处理边界问题时,都极其重视双边的经济合作问题,在经济一体化框架内和平解决边界问题,探索并形成了经济合作与边界问题和平协商解决相辅相成、良性互动的欧盟模式,并最终构建了欧盟统一边境制度。     

维度技术在XBRL分类标准中的应用研究

XBRL是应用于会计信息化领域的最新技术,而维度技术是XBRL技术研究的热点和难点之一。本文通过对典型XBRL分类标准的分析研究,针对其应用过程中存在的报表业务内容割裂和冗余元素过多等共性问题,采用XBRL维度技术,提出基于空超立方体实现非维度化基础元素的维度化解决方案和基于空维度去除冗余元素的解决方案,在不改变原有应用方式的基础上,加强了分类标准的业务完整性和实例文档的可验证性。     

现阶段我国西部少数民族省区的现代化状况分析

本文从国内较为流行的"二次现代化理论"出发,对现阶段我国西部少数民族省区的现代化状况做了简要的分析和探讨,并提出了加快其现代化进程的措施和建议.     

基于知识吸纳的物流企业能力演化机理探析

从惯例的角度探讨构成现代物流企业能力的关键要素,研究物流企业能力提升机理后可知,物流企业核心能力源于其运营能力和知识吸纳能力的集合,企业的能力由惯例集合及其所属资源构成。物流企业运营能力可归纳为市场识拓能力、服务管理能力、技术创新能力及网络组织能力;知识吸纳能力可归纳为外部与内部两部分。其中,运营能力是维持物流企业生存的基础能力,知识吸纳能力是更高一级的能力集合。知识吸纳能力作用于运营能力从而引发惯例演化,在惯例演化过程中管理层扮演着至关重要的角色,只有那些与公司战略匹配、通过协同效应验证及分层次选择的新惯例才会被选择并保留下来。     

Periostin基因多态性与汉族人群心力衰竭发病的初步研究

目的:研究Periostin基因多态性与汉族人群心力衰竭发病的关系?方法:采用聚合酶链反应-限制性片段长度多态法(PCR-RFLP)检测Periostin基因启动子区功能性位点(SNP C-33G)基因型?病例组选自心内科住院的心衰患者464例,对照组选自同期在医院健康体检或住院的正常人群640例?基因型及其他危险因素与心衰关系采用Logistic回归分析?结果:经过年龄?性别?血压?血糖?吸烟?高脂血症等多因素Logistic回归校正,Periostin 基因rs3829365位点的CG or GG基因型是心力衰竭的一个独立危险因素;在吸烟的心衰患者中,Periostin C-33G的CG or GG基因型可能起到保护作用?结论:Periostin基因rs3829365位点可能有助于心衰易感性和严重性的判断?