Dimension reduction via local rank regression

Outer product of gradients (OPG) achieves dimension reduction via estimating the gradients of the regression function. In this paper, we propose two novel OPG estimators via local rank regression: the rank OPG estimator and the Walsh-average OPG estimator. Both proposals guard against a wide range of error distributions, and are safe alternatives to existing OPG estimators based on local linear regression or local L1 regression. The effectiveness of the new proposals are demonstrated via extensive numerical studies.     

营业转让问题探讨

为了对我国营业转让的实践和立法有所帮助,文章运用比较分析的方法,对营业概念、营业转让的界定、营业转让中职工权益的保护以及营业转让平台的完善等问题进行了探讨.研究表明,由于我国法律未对营业转让进行明确规定,以致营业转让活动中存在着许多不规范、不合法的因素,阻碍了营业转让的顺利实现.指出我国立法机关应该借鉴国外法律,尽快制定全面、明确的营业转让制度,来规范、引导日益频繁的营业转让活动.     

社会整合与中国社会发展

马克思有关社会的发展理论仍然是解释中国社会发展的主要模式,但是在具体解释一些中国历史现象时也会遇到一些问题.如何来解决这些问题,笔者试图以社会整合为视角,对中国的社会发展进行重新论证,以弥补马克思社会发展理论的不足.依据社会整合,中国社会可分为六个发展阶段:血缘社会、宗法政治社会、君主专制社会、半专制半殖民地社会、现代权力社会和权力与经济并重的社会.由中国漫长的发展过程,可以看出民主化以及市场经济的运作机制都没有充分发展起来,这将是中国未来社会的发展方向.     

SPECIAL ISSUE： ONLINE LITERATURE IN CHINA： PRESENT SITUATION AND THEORETICAL REFLECTIONS Online Writing in the Course of Discourse Transformation： A Review of Ten Outstanding Online Novels of the Past Decade

中国当代文学阅读层面上的价值认同正在经受前所未有的挑战。特别是新世纪以来，新的写作群体、写作方式不断涌现，使固有的理论批评体系遭到撞击、被撕裂，从而导致理论批评不时出现失语现象。随着网络文学的迅猛发展，非主流文学在阅读与消费环节中的影响日益增强，这就使得上述问题转化成了新的矛盾——互相不能包容的阅读隔膜。十多年来，网络上产生了海量的小说文本，逐渐形成了二十多种类型；本文兼顾时间跨度和创作类型，遴选了十年中不同类型的十部佳作，并针对它们区别于纸质媒体的艺术审美和创作特点进行了述评。     

人生转折的临界点--母题数字"十三"与藏族成年礼

数字“十三”在藏族早期文化中的大量出现,其背后具有深层的文化精神作支撑。文章从藏族“十三”的一系列民俗思想中发现,“十三”是人生重要转折时期———成年礼的临界点。这种成年礼习俗在周边民族中依然存在。     

Penalized proportion estimation for non parametric mixture of regressions

Abstract

In this article, we propose a penalized local log-likelihood method to locally select the number of components in non parametric finite mixture of regression models via proportion shrinkage method. Mean functions and variance functions are estimated simultaneously. We show that the number of components can be estimated consistently, and further establish asymptotic normality of functional estimates. We use a modified EM algorithm to estimate the unknown functions. Simulations are conducted to demonstrate the performance of the proposed method. We illustrate our method via an empirical analysis of the housing price index data of United States.     

制度环境、风险感知对供应链网络治理模式选择的影响研究

本文以新制度理论与交易成本理论进行对话,从合法性视角构建中国情境下制度环境、风险感知与供应链网络治理模式选择之间影响机理的理论模型。通过问卷调查的方式收集117份有效问卷,并采用结构方程模型方法实证检验制度环境、风险感知对供应链网络治理模式的"形塑"作用。研究结果表明,制度环境是影响供应链网络治理模式选择的重要因素,强制制度对供应链网络治理模式选择具有显著影响,规范制度的影响作用不显著。在供应链网络治理模式选择过程中关系风险感知具有完全中介作用,而绩效风险感知具有部分中介作用。     

我国科技社团存在的问题与对策分析

目前,科技社团主要存在工作人员收入偏低、资金能力不足、社会对科技社团认可度不高等问题。为了确保科技社团能够健康、可持续地发展,需要通过规范内部运行机制、加强政府与科技社团的联系、完善监督机制、以会员为本、扩大资金来源五个方面来实现。     

路径与旨趣：近代浙江文化史研究嬗变

近代江南史研究见证并参与了近代中国社会文化的变迁,相比上海、苏南等地,浙江近代文化史研究亟需进一步拓展与深化。以革命与事件、结构与认同、学人与学派等研究路径为线索,回顾浙江近代文化史研究的关键要素,应能展望今后研究的方向：去意识形态化、突破单向度思维,以多元视角阐释近代浙江的革命群体与事件;揭示近代浙江文化现象背后深层次的社会关系和权力关系、结构与心态、集体记忆与文化认同,进一步认知近代精英与民众、国家与社会的能动关系;浙江学人在近代学术流变中发挥承前启后的作用,学人学术思想的本意及其实践成为近代浙学重建的重要参考。运用整体视角综合事件、结构、学理,积极拓展史料与理论范式,深入发掘近代浙江文化的历史经验和内在脉络,将为探索中国原理提供有效的知识与思想资源。     

Modelling PK/QT relationships from Phase I dose‐escalation trials for drug combinations and developing quantitative risk assessments of clinically relevant QT prolongations

In current industry practice, it is difficult to assess QT effects at potential therapeutic doses based on Phase I dose‐escalation trials in oncology due to data scarcity, particularly in combinations trials. In this paper, we propose to use dose‐concentration and concentration‐QT models jointly to model the exposures and effects of multiple drugs in combination. The fitted models then can be used to make early predictions for QT prolongation to aid choosing recommended dose combinations for further investigation. The models consider potential correlation between concentrations of test drugs and potential drug–drug interactions at PK and QT levels. In addition, this approach allows for the assessment of the probability of QT prolongation exceeding given thresholds of clinical significance. The performance of this approach was examined via simulation under practical scenarios for dose‐escalation trials for a combination of two drugs. The simulation results show that invaluable information of QT effects at therapeutic dose combinations can be gained by the proposed approaches. Early detection of dose combinations with substantial QT prolongation is evaluated effectively through the CIs of the predicted peak QT prolongation at each dose combination. Furthermore, the probability of QT prolongation exceeding a certain threshold is also computed to support early detection of safety signals while accounting for uncertainty associated with data from Phase I studies. While the prediction of QT effects is sensitive to the dose escalation process, the sensitivity and limited sample size should be considered when providing support to the decision‐making process for further developing certain dose combinations. Copyright © 2016 John Wiley & Sons, Ltd.