Statistical Inference of Adaptive Designs with Binary Responses

Adaptive designs of clinical trials are ethical alternatives when the traditional randomization becomes ethically infeasible in desperate medical situations. However, such a design creates a dependency among trial data and its statistical analysis becomes more complex than the analysis for traditional randomized clinical trials. In this article, we examine adaptive designs with dichotomous responses from two treatments and extend some commonly used statistical methods for independent data. Under a regularity condition, the estimated odds ratio and its logarithm are shown to follow asymptotically normal distributions. Moreover, the ordinary goodness-of-fit test statistic for two-by-two contingency tables with dependent data is shown to be asymptotically chi-square distributed. We also discuss the consistency of maximum likelihood estimators of the unknown parameters for a wide class of adaptive designs.     

Influence Diagnostics of Semiparametric Nonlinear Reproductive Dispersion Models

This article proposes a semiparametric nonlinear reproductive dispersion model (SNRDM) which is an extension of nonlinear reproductive dispersion model and semiparametric regression model. Maximum penalized likelihood estimators (MPLEs) of unknown parameters and nonparametric functions in SNRDMs are presented. Some novel diagnostic statistics such as Cook distance and difference deviance for parametric and nonparametric parts are developed to identify influence observations in SNRDMs on the basis of case-deletion method, and some formulae readily computed with the MPLEs algorithm for diagnostic measures are given. The equivalency of case-deletion models and mean-shift outlier models in SNRDM is investigated. A simulation study and a real example are used to illustrate the proposed diagnostic measures.     

A prior-valued estimator applied to multinomial classification

A multinomial classification rule is proposed based on a prior-valued smoothing for the state probabilities. Asymptotically, the proposed rule has an error rate that converges uniformly and strongly to that of the Bayes rule. For a fixed sample size the prior-valued smoothing is effective in obtaining reason¬able classifications to the situations such as missing data. Empirically, the proposed rule is compared favorably with other commonly used multinomial classification rules via Monte Carlo sampling experiments     

Dependence function for continuous bivariate densities

The notion of cross-product ratio for discrete two-way contingency table is extended to the case of continuous bivariate densities. This results in the “local dependence function” that measues the margin-free dependence between bivariate random variables. Properties and examples of the dependence function are discussed. The bivariate normal density plays a special role since it has constant dependence. Continuous bivariate densities can be constructed by specifying the dependence function along with two marginals in analogy to the construction of two-way contingency tables given marginals and patterns of interaction. The dependence function provides a partial ordering on bivariate dependence.     

Performance analysis of the retrial queues with finite number of sources and service interruptions

This paper aims at presenting an analytic approach for investigating a single-server retrial queue with finite population of customers where the server is subject to interruptions. A free source may generate a primary call to request service. If the server is free upon arrival, the call starts to be served and the service times are independent, generally distributed random variables. During the service time the source cannot generate a new primary call. After service the source moves into the free state and can generate a new primary call. There is no waiting space in front of the server, and a call who finds the server unavailable upon arrival joins an orbit of unsatisfied customers. The server is subject to interruptions during the service processes. When the server is interrupted, the call being served just before server interruption goes to the retrial orbit and will retry its luck after a random amount of time until it finds the server available. The recovery times of the interrupted server are assumed to be generally distributed. Our analysis extends previous work on this topic and includes the analysis of the arriving customer’s distribution, the busy period, and the waiting time process.     

On the estimation of variance components in stability analysis

Chow and Shao (1989, 1991) indicated that the presence of batch-to-batch variation has an impact on the determination of drug shelf-life in stability studies. In this paper, we propose two unbiased estmators for batch-to-batch variation. The proposed estimators are compared in terms of their corresponding variances. An example concerning a stability study is discussed to illustrate the use of the proposed estimators.     

Marginally oversaturated designs

A special class of supersaturated design, called marginally over saturated design (MOSD), in which the number of variables under investigation (k) is only slightly larger than the number of experimental runs (n), is presented. Several optimality criteria for supersaturated designs are discussed. It is shown that the resolution rank criterion is most appropriate for screening situations. The construction method builds on two major theorems which provide an efficient way to evaluate resolution rank. Examples are given for the cases n=8, 12, 16, and 20. Potential extensions for future work are discussed.     

Phase-shifting common cycles and common trends

In this paper, we outline a framework for modelling and analysing economic fluctuations and dynamics. It is assumed that there may exist common trends and common cycles in the time series to be analysed It is further generalised that common cycles may have non-coincident, or phase-shifting attributes These attributes are examined via the Markov transition matrix in a VAR system, revealing the way in which the phase-shifting works with the reduced rank Markov transition matrix. The links with the structural common trend model are also presented.     

Extreme Quantile Estimation for Autoregressive Models

ABSTRACT

A quantile autoregresive model is a useful extension of classical autoregresive models as it can capture the influences of conditioning variables on the location, scale, and shape of the response distribution. However, at the extreme tails, standard quantile autoregression estimator is often unstable due to data sparsity. In this article, assuming quantile autoregresive models, we develop a new estimator for extreme conditional quantiles of time series data based on extreme value theory. We build the connection between the second-order conditions for the autoregression coefficients and for the conditional quantile functions, and establish the asymptotic properties of the proposed estimator. The finite sample performance of the proposed method is illustrated through a simulation study and the analysis of U.S. retail gasoline price.