Semiparametric median residual life model and inference

For randomly censored data, the authors propose a general class of semiparametric median residual life models. They incorporate covariates in a generalized linear form while leaving the baseline median residual life function completely unspecified. Despite the non‐identifiability of the survival function for a given median residual life function, a simple and natural procedure is proposed to estimate the regression parameters and the baseline median residual life function. The authors derive the asymptotic properties for the estimators, and demonstrate the numerical performance of the proposed method through simulation studies. The median residual life model can be easily generalized to model other quantiles, and the estimation method can also be applied to the mean residual life model. The Canadian Journal of Statistics 38: 665–679; 2010 © 2010 Statistical Society of Canada     

Partitioned log-rank tests for the overall homogeneity of hazard rate functions

In survival analysis, it is routine to test equality of two survival curves, which is often conducted by using the log-rank test. Although it is optimal under the proportional hazards assumption, the log-rank test is known to have little power when the survival or hazard functions cross. To test the overall homogeneity of hazard rate functions, we propose a group of partitioned log-rank tests. By partitioning the time axis and taking the supremum of the sum of two partitioned log-rank statistics over different partitioning points, the proposed test gains enormous power for cases with crossing hazards. On the other hand, when the hazards are indeed proportional, our test still maintains high power close to that of the optimal log-rank test. Extensive simulation studies are conducted to compare the proposed test with existing methods, and three real data examples are used to illustrate the commonality of crossing hazards and the advantages of the partitioned log-rank tests.     

Bayesian adaptive dose‐escalation designs for simultaneously estimating the optimal and maximum safe dose based on safety and efficacy

The main purpose of dose‐escalation trials is to identify the dose(s) that is/are safe and efficacious for further investigations in later studies. In this paper, we introduce dose‐escalation designs that incorporate both the dose‐limiting events and dose‐limiting toxicities (DLTs) and indicative responses of efficacy into the procedure. A flexible nonparametric model is used for modelling the continuous efficacy responses while a logistic model is used for the binary DLTs. Escalation decisions are based on the combination of the probabilities of DLTs and expected efficacy through a gain function. On the basis of this setup, we then introduce 2 types of Bayesian adaptive dose‐escalation strategies. The first type of procedures, called “single objective,” aims to identify and recommend a single dose, either the maximum tolerated dose, the highest dose that is considered as safe, or the optimal dose, a safe dose that gives optimum benefit risk. The second type, called “dual objective,” aims to jointly estimate both the maximum tolerated dose and the optimal dose accurately. The recommended doses obtained under these dose‐escalation procedures provide information about the safety and efficacy profile of the novel drug to facilitate later studies. We evaluate different strategies via simulations based on an example constructed from a real trial on patients with type 2 diabetes, and the use of stopping rules is assessed. We find that the nonparametric model estimates the efficacy responses well for different underlying true shapes. The dual‐objective designs give better results in terms of identifying the 2 real target doses compared to the single‐objective designs.     

建立面向中国-东盟会展产业的研究生培养模式

会展产业作为“朝阳产业”,近年来在中国发展迅猛,刺激了会展人才需求,每年需新增从业人员20多万。但现有会展人才缺乏,高级会展人才尤缺,不能满足发展需求。广西借助每年举办中国—东盟博览会、中国—东盟商务与投资峰会和南宁国际民歌艺术节,大力发展”中国—东盟”会展产业,急需一批高素质、具有东盟文化特色的高级会展人才。针对于此,应加强会展产业的研究生培养,通过高校联合办学、加强学科建设,与会展管理部门、行业协会、企业等机构的合作等途径来共同培养。     

The price of fairness for a two-agent scheduling game minimizing total completion time

Journal of Combinatorial Optimization - This paper studies the price of fairness in a two-agent single machine scheduling game. In this game, two agents compete to perform their jobs on a common...     

启蒙与传统

很多学者谈"启蒙"最大的弊端是抽离了启蒙的历史具体性,空谈启蒙,这个历史的具体性就是传统.传统思想对外来思想的统摄虽然被认识到,实际上重视不够.启蒙在实践层面并不仅仅是价值问题,而是各种力量的博弈,有效的启蒙必然在各项条件都具备的时候,这就需要考虑启蒙的策略.长期以来,这个问题被掩盖了,单纯以价值判断代替了实践层面可行性的思考.实践层面可行性主要是对传统的深厚理解和把握,从中找出与启蒙思想的共鸣,因势利导,在不导致社会动乱的前提下推进社会的变革.这个过程也就是启蒙思想的本土化过程.     

魏晋南北朝私学教育内容多元化格局述论

魏晋南北朝私学之所以昌盛 ,与它教育内容十分丰富有关。不仅包含有儒、佛、道、玄、文、史、艺术、科技等 ,道德教育也成为一项重要内容。私学教育内容上的多元化 ,成为私学教育的鲜明特点。这使教育具有了实用性     

运动与运动性蛋白尿

讨论了运动训练对肾脏功能的影响，即运动性蛋白尿的影响因素及蛋白尿的形成机制；同时，论述了蛋白尿等指标在运动实践中的应用