Summary of the Workshop on Issues in Risk Assessment: Quantitative Methods for Developmental Toxicology

This report summarizes the proceedings of a conference on quantitative methods for assessing the risks of developmental toxicants. The conference was planned by a subcommittee of the National Research Council's Committee on Risk Assessment Methodology ⁴ in conjunction with staff from several federal agencies, including the U.S. Environmental Protection Agency, U.S. Food and Drug Administration, U.S. Consumer Products Safety Commission, and Health and Welfare Canada. Issues discussed at the workshop included computerized techniques for hazard identification, use of human and animal data for defining risks in a clinical setting, relationships between end points in developmental toxicity testing, reference dose calculations for developmental toxicology, analysis of quantitative dose-response data, mechanisms of developmental toxicity, physiologically based pharmacokinetic models, and structure-activity relationships. Although a formal consensus was not sought, many participants favored the evolution of quantitative techniques for developmental toxicology risk assessment, including the replacement of lowest observed adverse effect levels (LOAELs) and no observed adverse effect levels (NOAELs) with the benchmark dose methodology.     

Significance of the Dermal Route of Exposure to Risk Assessment

The skin is a route of exposure that needs to be considered when conducting a risk assessment. It is necessary to identify the potential for dermal penetration by a chemical as well as to determine the overall importance of the dermal route of exposure as compared with inhalation or oral routes of exposure. The physical state of the chemical, vapor or liquid, the concentration, neat or dilute, and the vehicle, lipid or aqueous, is also important. Dermal risk is related to the product of the amounts of penetration and toxicity. Toxicity involves local effects on the skin itself and the potential for systemic effects. Dermal penetration is described in large part by the permeability constant. When permeability constants are not known, partition coefficients can be used to estimate a chemical's potential to permeate the skin. With these concepts in mind, a tiered approach is proposed for dermal risk assessment. A key first step is the determination of a skin-to-air or skin-to-medium partition coefficient to estimate a potential for dermal absorption. Building a physiologically-based pharmacokinetic (PBPK) model is another step in the tiered approach and is useful prior to classical in vivo toxicity tests. A PBPK model can be used to determine a permeability constant for a chemical as well as to show the distribution of the chemical systemically. A detailed understanding of species differences in the structure and function of the skin and how they relate to differences in penetration rates is necessary in order to extrapolate animal data from PBPK models to the human. A study is in progress to examine anatomical differences for four species.     

浅谈网络德育的重要性

面对网络时代的到来,如何在新的时代更好地把握时代脉搏,探索新的育人之路,是学校德育工作的重大课题,更是新时期班主任必须关注的一个新的课题;培养青少年正确的信息道德观是全社会的重大责任,关键在于形成一个社会、学校、家庭、媒体各方面结合的网络道德教育体系。     

Role of informal sector recycling in waste management in developing countries

Many thousands of people in developing country cities depend on recycling materials from waste for their livelihoods. With the focus of the Millennium Development Goals on poverty reduction, and of waste strategies on improving recycling rates, one of the major challenges in solid waste management in developing countries is how best to work with this informal sector to improve their livelihoods, working conditions and efficiency in recycling.The general characteristics of informal recycling are reviewed, highlighting both positive and negative aspects. Despite the health and social problems associated with informal recycling, it provides significant economic benefits that need to be retained. Experience shows that it can be highly counterproductive to establish new formal waste recycling systems without taking into account informal systems that already exist. The preferred option is to integrate the informal sector into waste management planning, building on their practices and experience, while working to improve efficiency and the living and working conditions of those involved. Issues associated with integrating informal recycling into the formal waste management sector are discussed.     

Teaching Disability Studies in Canada and the USA

Using a 1993 sample (n=107) of persons who teach disability studies courses, a sample (n=27) of disability studies syllabi from the early 1980s, and an extensive bibliography the authors discuss the history and the present condition of disability studies courses in the US and Canada. They discuss the disability paradigm and the methodology used in disability studies courses. The variety and geographical spread of such courses are noted. An extensive comparison of syllabi from the 1980s and the 1990s, including the reading assignments, is carried out.     

环境会计信息披露的有关问题

企业作为环境污染的主要肇事者, 理应承担起治理环境污染的责任, 由此就会产生相应的环境支出和环境收益, 并因而影响企业的财务状况和经营成果。将环境活动纳入企业会计核算体系, 反映企业对自然资源的消耗和对环境的污染及其治理情况, 披露环境会计信息, 成为传统会计面临的新课题, 本文主要对环境会计信息披露的内容和方式进行探讨     

丰水区筑坝截流——调丰补歉

该文从中国人口快速增长、经济建设加快、用水量逐年增大 ,加上气候变暖、少雨干旱将持续到 2 0 15年 ,我国北方水生态环境日趋恶化现状 ,说明在丰水区筑坝截流、调丰补歉势在必行 ,完全符合生态经济学发展原则和国际水法     

师德建设在实现高校德育目标中的作用

在高等学校广义的德育工作中 ,师德建设是一个重要的组成部分。从学生思想品德的形成过程 ,分析教师道德素质对学生健康成长的影响 ,探讨师德建设在实现高校德育目标中的作用 ,以期达到改进高校德育工作方式 ,拓宽德育工作途径 ,提高德育工作实效的目的