A screening system for tardive dyskinesia: development and implementation.

1. Most diagnosed cases of tardive dyskinesia (TD) are mildly inconvenient to the patient, but some can be severe or life-threatening. The primary goal of intervention should be early identification of abnormal movements related to TD and the prescribing of an appropriate medication regimen. 2. Unless specific training occurs and a specific monitoring system is in place, TD movements may be missed. However, not all movements are necessarily related to TD. 3. Although screening and monitoring are valuable, nothing is more important than prevention. New medications must be developed that do not carry the risk of TD, and other approaches to treat TD must be developed.     

The analysis of incomplete data using stochastic covariates

In the development of many diseases there are often associated random variables which continuously reflect the progress of a subject towards the final expression of the disease (failure). At any given time these processes, which we call stochastic covariates, may provide information about the current hazard and the remaining time to failure. Likewise, in situations when the specific times of key prior events are not known, such as the time of onset of an occult tumour or the time of infection with HIV-1, it may be possible to identify a stochastic covariate which reveals, indirectly, when the event of interest occurred. The analysis of carcinogenicity trials which involve occult tumours is usually based on the time of death or sacrifice and an indicator of tumour presence for each animal in the experiment. However, the size of an occult tumour observed at the endpoint represents data concerning tumour development which may convey additional information concerning both the tumour incidence rate and the rate of death to which tumour-bearing animals are subject. We develop a stochastic model for tumour growth and suggest different ways in which the effect of this growth on the hazard of failure might be modelled. Using a combined model for tumour growth and additive competing risks of death, we show that if this tumour size information is used, assumptions concerning tumour lethality, the context of observation or multiple sacrifice times are no longer necessary in order to estimate the tumour incidence rate. Parametric estimation based on the method of maximum likelihood is outlined and is applied to simulated data from the combined model. The results of this limited study confirm that use of the stochastic covariate tumour size results in more precise estimation of the incidence rate for occult tumours.     

Inequalities for variances of some functions of random variables

In this note we prove some inequalities for variances and other measures of deviation of functions of random variables. Based on these inequalities we find some corollaries concerning the variances of fractional powers of random variables and of sums of independent random variables.     

Construction and selection of tightened-normal-tightened sampling inspection scheme of type TNT-(n1, n2; c)

A table is presented for the construction and selection of tightened-normal-tightened sampling scheme of type TNT-(n1, n2;c). Efficiency of TNT-(n1, n2;c) scheme over conventional single and double sampling plans is discussed.     

HIV-infected woman. Illness cognition assessment.

1. Special attention is particularly important in addressing the mental health needs of HIV-infected women. These needs may involve issues such as concerns about present or future pregnancy; child-rearing, often as single parents; poverty, illicit drug use or addiction; and the potential lack of support services. 2. Diagnosis of HIV infection in women may be overlooked, as the clinical signs that routinely trigger the suspicion of HIV illness in men are often interpreted to reflect depression or psychological factors, such as stress or overwork, rather than raise the suspicion of HIV infection in women. 3. Understanding a woman's illness cognition is an important component of designing strategies that can enhance coping. The picture a woman generates regarding her illness is a composite of her experiences and responses, and determines to a large extent what she will do in response to her illness.     

Procedures and tables for the construction and selection of chain sampling plans ChSP-4A(c1, c2,)r-Part 4

In this part of the series, the notion of average total inspection (ATI) is introduced to ChSP-4A(c1, c2)r plans, minimizing ATI at a given process average, while protection to the consumer is given in terms of average outgoing quality limit and limiting quality level. The procedure is similar to that of Dodge and Roming.     

Using computers to develop concept models of social situations

Concept modeling is presented as a way to describe and understand social situations. Concepts are developed from field data and supported by sets of exemplars drawn from the data which illustrate the various concepts. The computer is considered an essential tool for conducting this type of qualitative data analysis and displaying the resulting concept models. Two sample concept models are presented along with a discussion of how concept models can be related to teaching and learning, as well as to the nonlinear presentation of research results. Assessment of concept models is then considered. Three types of assessment are suggested: empirical, qualitative and quantitative.     

Commuting and the rural-urban hierarchy

The purpose of this paper is to consider the relation between commuting and the settlement structure, with particular attention to rural and nonmetropolitan areas. I examined commuting flows between metropolitan central cities, other metropolitan areas, nonmetropolitan places with more than 10,000 people, those with 2500–10000 people, and other rural areas. Despite the deconcentration of population, industry and trade that was especially marked in the 1970s, commuting in 1980 was predominantly toward larger places in the ruralurban hierarchy, and particularly from rural areas and the other metropolitan category to cities. Overall levels of commuting were high, and most were within either nonmetropolitan or metropolitan areas. Smaller nonmetropolitan places particularly had high proportions of both in- and out-commuters. Differences in commuting flows by gender, socioeconomic status and industry were small, but generally in the directions expected on the basis of prior research. The findings reveal a high degree of work-residence interdependence among settlement units in nonmetropolitan America, with social and economic differences in commuting flows representing an important aspect of community structure.