Mixture modelling as an exploratory framework for genotype-trait associations

We propose a mixture modelling framework for both identifying and exploring the nature of genotype-trait associations. This framework extends the classical mixed effects modelling approach for this setting by incorporating a Gaussian mixture distribution for random genotype effects. The primary advantages of this paradigm over existing approaches include that the mixture modelling framework addresses the degrees-of-freedom challenge that is inherent in application of the usual fixed effects analysis of covariance, relaxes the restrictive single normal distribution assumption of the classical mixed effects models and offers an exploratory framework for discovery of underlying structure across multiple genetic loci. An application to data arising from a study of antiretroviral-associated dyslipidaemia in human immunodeficiency virus infection is presented. Extensive simulations studies are also implemented to investigate the performance of this approach.     

2011 MOBIUS Conference

The twelfth annual MOBIUS Conference was held June 7–9, 2011, at the Holiday Inn Executive Center in Columbia, Missouri. The MOBIUS consortium of Missouri is currently composed of fifty-nine academic libraries, two public libraries, and the Missouri State Library. The conference offered various opportunities, including a keynote address by Meredith Farkas and a networking dessert session on the first night. The second day featured six concurrent sessions, each having six different presentations, along with delicious food, generous door prizes, and the chance to meet with vendors. The third day consisted of four different four-hour post-conference training sessions. Presentations are available for download from the conference Web site.¹     

Development and Validation of the Post-Dissolution Relational Communication Index

Relational dissolution is a distressing life event. Dissolution is further complicated when communication between ex-partners is inefficient, unpredictable, and strained. This examination uncovers the aspects of postdissolutional communication in a 2-part study. In Study 1, 271 participants experiencing a breakup completed surveys regarding their communication with an ex-romantic partner. The study empirically operationalizes these behaviors in the Post-Dissolution Relational Communication Index and reports on the factor structure, reliability, and convergent validity of the 2-factor solution produced. Both factors were significantly correlated with participants’ reports of communication satisfaction with a former relationship partner and the perceived seriousness of the relationship. In Study 2, self-reports from 151 participants who had experienced a divorce provided support for its use with divorced couples. A third factor was identified illustrating differences between nonmarital and marital ex-partners. Implications for postdissolution relationships and satisfaction with former partners are addressed. Furthermore, suggestions for practice are discussed.     

Folate: a possible role in erectile dysfunction?

A growing body of evidence suggests a role for homocysteine (Hcys) and folate (FA) in erectile function (EF): Hcys appears to impair EF affecting endothelium via several mechanism whereas the role of FA remains to be elucidated, besides decreasing Hcys. To assess correlation between erectile dysfunction (ED) and serum levels of FA, Hcys, and B12, we enrolled 31 patients affected by ED (Group A; age 52.83?±?11.89 years) and 31 healthy adults (Group B; age 49.14?±?13.63 years). Fasting blood samples were taken for each subject. ED was assessed by the International Index of Erectile Function-5 (IIEF-5). IIEF-5 mean score was significantly lower in Group A than in Group B (10.71?±?4.24 versus 23.32?±?1.33, p?p?p?相似文献   

The perfect lawn: exploring neighborhood socio-cultural drivers for insect pollinator habitat

In the United States, residential yards are typically overlooked for biodiversity conservation, yet they account for a significant portion of urban green space. Yard vegetation can serve as valuable habitat patches for insect pollinator populations in cities, providing important foraging and nesting resources. Based on long-term native bee sampling data, we investigate the social and cultural drivers shaping front yard vegetation composition and configuration at two study sites with consistently low native bee species diversity and abundance. We employ quantitative remote sensing approaches with analysis of qualitative interview data to examine residential vegetation patterns and analyze the socio-cultural relationships between people and vegetation. Data analyses reveal both study sites have lower levels of vegetation composition and complexity, resulting in reduced habitat resources. We find neighborhood public-facing landscaping is shaped by various socio-cultural influences: aesthetics, norms, reference-group behavior, institutions, socioeconomics, and identity. Front yard land-use and decision-making practices are particularly meaning laden, as these spaces are often perceived as visible representations of longstanding neighborhood identity and contiguous common areas to be managed to a “perfect lawn” ideal. The quantitative and qualitative data are used to characterize the two study sites and inform future urban conservation and development efforts salient to citizen stakeholders.     

Implications of parents’ work travel on youth adjustment

Guided by ecological, work–family spillover and crossover frameworks, this study examined mechanisms linking parental work travel (i.e. nights per year) to youth adjustment (i.e. externalizing and internalizing behaviours) through youth’s perceptions of parenting (i.e. knowledge, solicitation) with traveller and youth gender as moderators in a sample of 78 children in 44 two-parent families residing in the United States. The findings from multilevel analyses suggested that mothers’ travel nights predicted lower levels of maternal knowledge, with variation by traveller and youth gender. Mothers’ and fathers’ work travel and perceived parenting were predictors of youth’s externalizing behaviours, whereas only fathers’ work travel and perceived parenting were predictors of youth’s internalizing behaviours. Tests of indirect effects indicated that maternal work travel linked to youth’s externalizing behaviours through youth’s perceptions of maternal knowledge. These findings add to our limited understanding of work–family issues for parents who have the unique work demand of frequently travelling.     

Queering the Palimpsest: Affective Entanglement Beyond Dichotomization

In Cultural Studies, the affective turn is a response to the so-called crisis of representation. Insisting on a crucial difference, some theorists separate representation as it is addressed in psychoanalytic accounts of the subject, from pre-individual bodily capacities, as they are developed in affect theory. In our article, we are revisiting Freud’s model of the mystic writing pad and present a metaphor enhancing an inclusive approach to both: the palimpsest. Following Ahmed and Butler, we understand subjectivity as a constant process of affective surfacing, in which intrapersonal and interpersonal dimensions constitute each other. The metaphor of the palimpsest offers a way to theorize subjectivity as structured by power relations yet open to potentiality, paying attention to the intrapsychic as affective force within encounters between subjects. “Queering the palimpsest” disrupts the dichotomization of ontology versus epistemology, the dichotomous ways of gendering the subject and the “either-or-option” of affect theory and psychoanalysis.     

Motherhood,labor force behavior,and women’s careers: An empirical assessment of the wage penalty for motherhood in britain,germany, and the united states

Using harmonized longitudinal data from the British Household Panel Survey (BHPS), the German Socio-Economic Panel (GSOEP), and the National Longitudinal Survey of Youth (NLSY), we trace career prospects after motherhood for five cohorts of American, British, and West German women around the 1960s. We establish wage penalties for motherhood between 9% and 18% per child, with wage losses among American and British mothers being lower than those experienced by mothers in Germany. Labor market mechanisms generating the observed wage penalty for motherhood differ markedly across countries, however. For British and American women, work interruptions and subsequent mobility into mother-friendly jobs fully account for mothers’ wage losses. In contrast, respective penalties are considerably smaller in Germany, yet we observe a substantial residual wage penalty that is unaccounted for by mothers’ observable labor market behavior. We interpret this finding as indicating a comparatively more pronounced role for statistical discrimination against mothers in the German labor market.     

In the wake of radical right electoral success: a cross-country comparative study of anti-immigration attitudes over time

This paper tests the theoretically assumed relationship between the parliamentary presence of radical right parties (RRPs) and anti-immigration attitudes over time. Data come from six rounds of the European Social Survey between 2002 and 2012. Using multi-level models with applications for repeated cross-sectional data, the study examines the implications of changes tied to the political advancements of the radical right with a focus on three possible scenarios: people's attitudes about immigration have generally become more negative, opposition towards immigration has become more dependent on immigrants' ethnicity, and attitudes towards immigration have become more polarised. Contrary to expectations, it is found that neither the presence, the representational strength, nor the nationalistic framing of an RRP affect opposition towards immigration over time. Thus, the conclusion is that the RRPs, so far, have not driven anti-immigration attitudes in Europe. Possible explanations for these results are discussed in the concluding section.