Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva--TRELONG)

Insulin-like growth factor 1 (IGF-1) signaling modulation has been associated with increased lifespan in model organisms, while high levels of circulating interleukin-6 (IL-6) are a marker of disability and mortality. In the prospective, population-based "Treviso Longeva"--TRELONG Study from Italy (n = 668, age range 70-105.5 years at baseline, followed for seven years) we investigated the effects of survival on the IGF-1 receptor (IGF-1R) gene polymorphism rs2229765, the IL-6 gene promoter polymorphism rs1800795, and plasma concentrations of IGF-1 and IL-6, alone or in combination. We found a sex-dependent effect for the IGF-1R rs2229765 polymorphism, as male carriers of the homozygous A/A genotype survived longer, while the IL-6 rs1800795 genotype did not influence overall or sex-specific longevity. Higher IL-6 levels were more detrimental for survival among males than females, while IGF-1 had no dose-response effect. These findings sustain the hypothesis that sex-specific longevity relies on detectable differences in genetic and biochemical parameters between males and females.     

Multicultural supervision: lessons learned about an ongoing struggle

This article examines the experiences of seven diverse therapists in a supervision course as they wrestled with the real-world application of multicultural supervision. Existing literature on multicultural supervision does not address the difficulties that arise in addressing multicultural issues in the context of the supervision relationship. The experiences of six supervisory candidates and one mentoring supervisor in addressing multicultural issues in supervision are explored. Guidelines for conversations regarding multicultural issues are provided.     

Action-oriented evaluation of an in-home family therapy program for families at risk for foster care placement

The purpose of this study was to conduct an action-oriented evaluation of an in-home family therapy program serving families deemed at risk for the placement of children in foster care. In this study, feedback was solicited from both clients and therapists. Results indicate "duality" associated with several aspects of in-home family therapy, including the opportunity to observe families in their own homes versus the vulnerability some families feel when therapy is conducted in-home; therapists suggesting that sufficient training is required for in-home family therapy to be effective versus clients' opinions that therapists' lived experiences are more relevant; and the importance of the therapeutic alliance versus feelings of abandonment upon termination. Implications for researchers and practitioners are discussed.     

Modeling cost-delivery trade-offs for distribution logistics by a generalized PVRP model

This article provides a mathematical model to support management in making decisions about cost-delivery trade-offs in the case of cost-delivery flexibilities in distribution logistics. The optimization problem can be modeled as a bi-objective periodic vehicle routing problem, which is known as NP-hard. In the periodic vehicle routing problem considered in this study, no delivery patterns are pre-defined, instead the patterns are the result of the optimization process of the model. In addition, delivery time flexibilities are incorporated in the model. A heuristic solution method for realistic problem sizes is based on the tabu search procedure, and a real case study illustrates the applicability of the solution concept.     

Mobility ratios and association in mobility tables

In the late 1940's a similar problem occurred in the work of three sociologists, working in three countries, on three similar sets of data. Natalie Rogoff, David Glass and G6sta Carlsson all faced the problem of making sense of data on intergenerational occupational mobility. A matrix of frequencies of occupations of respondents by occupations of fathers could be converted, in an obvious and straightforward fashion, into matrices of inflow and outflow percentages. Their joint problem arose in comparing inflow percentages across rows or outflow percentages across columns. The problem was that, as sociologists, concerned with the extent that origins in socially meaningful categories influenced destinations in the same socially meaningful categories, they were stuck with occupational categories that differed from one another dramatically in size. A secondary (though hardly trivial) problem was the fact that, in all their data, the two marginal distributions, the respondents' generation and the fathers' ‘generation’, were notably dissimilar — a consequence of both differential fertility and a general upward shift in the occupational distributions of the three countries. All sought a technique that would ‘make the two time periods comparable with respect to occupational structure’.     

The Effect of a Multicomponent Dual-Modality Exercise Program Targeting Osteoporosis on Bone Health Status and Physical Function Capacity of Postmenopausal Women

Purpose: Exercise is important for the prevention of osteoporosis and the reduction of fracture risk because it improves muscle mass and strength, besides improving balance. We evaluated the effect of a specific exercise program on bone mass and quality and physical function capacity in postmenopausal women with low bone mineral density. Methods: Participants (N = 125) underwent a bone mass (Dual X-ray Absorptiometry), bone quality (osteosonography), and physical functional capacity assessment. Fifty-eight of them took part in an 11-month exercise program (E), that included a multicomponent (strength, aerobic capacity, balance, joint mobility) dual-modality (on ground and in the water; alternating group and home-based exercise periods) exercise regimen. The others represented a control group (C) that did not exercise. After the exercise program all participants were reevaluated. Results: After the training program: femoral neck T-score significantly improved in E; C significantly decreased all bone quality (osteosonography) parameters, whereas E showed no differences; E significantly improved all the physical function capacity parameters, while most of them decreased or did not change in C. Conclusions: A specific exercise program targeting osteoporosis improves physical function capacity, reduces physiological bone loss, and maintains bone quality in low bone mineral density postmenopausal women.     

How SES May Figure in Perceptions of Zika Risks and in Preventive Action

abstract

The present study intended to determine how the socioeconomic status (SES) of citizens and public health communications help explain citizens’ risk perception and actions taken during Zika virus outbreaks in 2016. We used data from a nationally representative study conducted in March 2016 by the Associated Press–National Opinion Research Center to analyze 831 American adult responses regarding Zika. We found that respondent risk perception and actions taken diminished as SES level rose. Risk perception was also found to mediate preventive actions’ associations. To quell the global spread of emerging infectious diseases (EIDs) like Zika, health organizations worldwide must understand how SES contributes to Zika (and other future EIDs) risk perception and preventive action. A more compelling form of public health communications must be developed that takes into account the impact made on future outbreaks and infections by these higher-SES “risk assessments.”