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41.
Sequential case series analysis for pharmacovigilance 总被引:1,自引:0,他引:1
Mounia N. Hocine Patrick Musonda Nick J. Andrews C. Paddy Farrington 《Journal of the Royal Statistical Society. Series A, (Statistics in Society)》2009,172(1):213-236
Summary. The self-controlled case series method is used to evaluate drug safety, particularly the safety of paediatric vaccines with respect to rare adverse reactions. We propose a group sequential version of the method for prospective surveillance of drug safety. We focus on the surveillance of new vaccines. We develop methods that are based on the sequential probability ratio test applied at predetermined surveillance intervals, using both simple and composite alternative hypotheses. We investigate the properties of the methods analytically in a simple setting and by simulations in more realistic scenarios. The methods are applied to data on influenza vaccine and Bell's palsy, and to data on measles, mumps and rubella vaccine and bleeding disorders. 相似文献
42.
This article draws upon data from semi-structured interviews conducted with black mixed-race males in the UK and the US, to argue that a revival of the black supplementary school movement could play an important role in the education of black mixed-race males. The article contends that a strong identification with blackness, and a concomitant rejection of the values of mainstream schooling, make black supplementary education a viable intervention for raising the attainment and improving the experiences of black mixed-race males. Whilst blackness was important to participants’ understandings of their lived experiences, this did not engender a disregard for their mixedness. Supplementary schools must therefore find ways of recognising black mixedness within their practice. 相似文献
43.
Donald W. K. Andrews Marcelo J. Moreira James H. Stock 《Econometrica : journal of the Econometric Society》2006,74(3):715-752
This paper considers tests of the parameter on an endogenous variable in an instrumental variables regression model. The focus is on determining tests that have some optimal power properties. We start by considering a model with normally distributed errors and known error covariance matrix. We consider tests that are similar and satisfy a natural rotational invariance condition. We determine a two‐sided power envelope for invariant similar tests. This allows us to assess and compare the power properties of tests such as the conditional likelihood ratio (CLR), the Lagrange multiplier, and the Anderson–Rubin tests. We find that the CLR test is quite close to being uniformly most powerful invariant among a class of two‐sided tests. The finite‐sample results of the paper are extended to the case of unknown error covariance matrix and possibly nonnormal errors via weak instrument asymptotics. Strong instrument asymptotic results also are provided because we seek tests that perform well under both weak and strong instruments. 相似文献
44.
Research on infants' perception and memory for social information are discussed with respect to the concept of ecological validity. We argue that the use of dynamic, multimodal displays in familiar contexts is critical to understanding infants' developing perception. We also discuss the importance of generalizing appropriately from experimental to real‐world contexts and of using converging methods in the investigation of infants' capabilities. 相似文献
45.
Model-based clustering typically involves the development of a family of mixture models and the imposition of these models
upon data. The best member of the family is then chosen using some criterion and the associated parameter estimates lead to
predicted group memberships, or clusterings. This paper describes the extension of the mixtures of multivariate t-factor analyzers model to include constraints on the degrees of freedom, the factor loadings, and the error variance matrices.
The result is a family of six mixture models, including parsimonious models. Parameter estimates for this family of models
are derived using an alternating expectation-conditional maximization algorithm and convergence is determined based on Aitken’s
acceleration. Model selection is carried out using the Bayesian information criterion (BIC) and the integrated completed likelihood
(ICL). This novel family of mixture models is then applied to simulated and real data where clustering performance meets or
exceeds that of established model-based clustering methods. The simulation studies include a comparison of the BIC and the
ICL as model selection techniques for this novel family of models. Application to simulated data with larger dimensionality
is also explored. 相似文献
46.
Using a new analytic approach, construct validity estimates are developed for proposed social indicators of self-reported well-being. Two separate investigations are reported: the first involves data on six aspects of well-being each assessed by six methods from 222 adults in one geographic area; the second, a partial replication and extension, involves a more limited set of indicators measured on a sample of 1297 respondents representative of all American adults. The results provide evidence that perceptions of well-being can be measured by single questionnaire or interview items using any of four formats with validities in the range of 0.7 to 0.8 and with correlated method effects contributing less than 10% of the total variance. Two other formats, however, were markedly less valid. These findings are important in view of past criticisms of ‘subjective’ social indicators as lacking in validity, and the findings can guide current efforts to develop new ways to assess the quality of life. Methodologically, the article illustrates the feasibility and utility of deriving parameter estimates of structural equation models of multimethod-multitrait data using Joreskog's LISREL algorithm. The possibility of deriving validity estimates in this way, even when the data include correlated errors, opens new and important opportunities to precisely assess the amount of error variance in much social science data. 相似文献
47.
本文利用北京老龄化多维纵向研究数据,对北京老年人的成功老龄化状况进行了分析.分析结果表明,年龄、性别、受教育程度和家庭经济状况等因素影响着成功老龄化.属于成功老龄化范畴的老年人主要是低年龄、男性、受教育时间长、拥有较多家庭财产或月收入的老年人.上述因素并不只对某一个年龄组产生影响,它们对老年的各个阶段都有影响.年龄的增长与老年人身体、心理和社会功能有着紧密的联系,在控制了年龄、性别、教育和收入变量之后,老年人之间的差异依然存在. 相似文献
48.
Emily Bullock‐Yowell Lindsay Andrews Mary E. Buzzetta 《The Career development quarterly》2011,59(5):400-411
The authors explore the hypothesis that career decision‐making self‐efficacy could be affected by negative career thoughts, Big Five personality factors, and cultural mistrust in a sample of African American and Caucasian college students. Findings demonstrated that negative career thinking, openness, and conscientiousness explained a significant amount of variance in career decision‐making self‐efficacy in a general sample of college students, but no unique variance was explained by cultural mistrust in a sample of African American college students. 相似文献
49.
Configurational theories assume that organizational form has important implications for the degree of alignment between top
and middle management on strategic priorities. Taken in combination, the structure, process and environment of an organization
are thought to have a deep pervasive influence on top management’s attempts to achieve the coordination and control required
to attain organizational goals. The preliminary analysis described in this article employs fuzzy c-means clustering to explore the relationship between middle managers’ perceptions of organizational form and strategic alignment
within a large local authority. The results illustrate that the clustering of managers’ perceptions of organizational structure,
process and environment reflect three organizational archetypes: machine bureaucracy, professional bureaucracy and professional
adhocracy. Statistically significant differences in the degree of strategic alignment between each of these organizational
forms are then examined to validate the established clustering. Finally, conclusions are drawn on the theoretical and practical
implications of the findings. 相似文献
50.
Stress from infertility, marriage factors, and subjective well-being of wives and husbands 总被引:9,自引:0,他引:9
Stress associated with the inability to have a child is linked to four aspects of marriage and to five dimensions of life quality. Data come from 157 couples who met a standard medical definition for infertility. Wives and husbands were interviewed independently, and most of the following findings apply to both. A causal model suggests that fertility problem stress has direct effects that increase marital conflict and decrease sexual self-esteem, satisfaction with own sexual performance, and frequency of sexual intercourse. Also, fertility problem stress has both direct and indirect effects (via the marriage factors) that decrease evaluations of life-as-a-whole, self-efficacy, marriage, intimacy, and health. The negative effects on life quality are stronger for wives than for husbands. The model suggests that the life quality of couples with fertility problems could be improved if health care providers and couples themselves took steps to reduce such stresses and/or reduce their impact on the marriage factors. 相似文献