An adaptive seamless phase II/III design for oncology trials with subpopulation selection using correlated survival endpoints

Although the statistical methods enabling efficient adaptive seamless designs are increasingly well established, it is important to continue to use the endpoints and specifications that best suit the therapy area and stage of development concerned when conducting such a trial. Approaches exist that allow adaptive designs to continue seamlessly either in a subpopulation of patients or in the whole population on the basis of data obtained from the first stage of a phase II/III design: our proposed design adds extra flexibility by also allowing the trial to continue in all patients but with both the subgroup and the full population as co-primary populations. Further, methodology is presented which controls the Type-I error rate at less than 2.5% when the phase II and III endpoints are different but correlated time-to-event endpoints. The operating characteristics of the design are described along with a discussion of the practical aspects in an oncology setting.     

No Fun Anymore: Leisure and Marital Quality Across the Transition to Parenthood

This study examines changes in leisure patterns across the transition to parenthood for dual‐earner, working‐class couples, as well as the relationship between leisure and marital quality. To this end, 147 heterosexual couples were interviewed across the transition to parenthood. Findings indicate that during the transition to parenthood, husbands and wives experience an initial decline in leisure, followed by a gradual incline after the wife’s return to work. Overall, wives who reported more shared leisure prenatally also reported more marital love and less conflict 1 year later. Husbands with more independent leisure prenatally reported less love and more conflict 1 year later. Conclusions suggest leisure time is integral to well‐functioning marriages, with effects lasting throughout the first year of parenthood.     

A theoretical framework for comparisons of social movement participation

This article attempts to draft a framework for the comparison of movement participation. The standards of comparison I developed at the movement level were the magnitude of mobilization potentials, the composition of multiorganizational fields, organizational characteristics, and action orientation. Utilizing this framework, I compared mobilization campaigns for three different types of activities conducted by three different movements: a campaign conducted by a labor union for, possibly, a strike, a campaign of the Dutch peace movement in a local community for a national demonstration, and campaigns by women's groups in a community for a variety of activities. I explain differences in motivational dynamics and levels of participation in terms of differing movement characteristics. Finally, I discuss the advantages of comparative work on social movements.     

Dementia of the Alzheimer's type and accelerated aging in Down syndrome

This case study, of a woman with Down syndrome and dementia of the Alzheimer's type (DAT), follows the course of her decline over an 11-year period until death at age 57. Detailed neuropathological findings are also presented. This case illustrates features of premature aging that are typically associated with Down syndrome, and the progressive changes in memory and cognition that are usually associated with DAT. Although the subject's cardiovascular condition and thyroid disorder were treated, they may have contributed to the decline of her memory. This case shows the difficulty in diagnosing dementia in an individual with mental retardation who suffered comorbid episodes of depression and psychosis.     

Creating High‐Technology Growth: High‐Tech Employment Growth in U.S. Metropolitan Areas, 1988–1998*

Objective. Growth in the share of high‐technology employment is critical to discussions of the postindustrial transition. Do new state and local technology policies create growth in the share of high‐technology employment? This article examines this question along with the effects of location and agglomeration advantages, identifying sources of qualitative growth in the U.S. economy. Methods. We examine change in the share of high‐technology employment in metropolitan statistical areas (MSAs) in the United States between 1988 and 1998. High‐technology employment is measured from the BLS Current Employment Statistics Survey. The scale of state and local technology policies are measured from a comprehensive survey of state and local technology programs. A generalized linear model (GLM) estimates the effects of technology policies along with regional proximity, location, and agglomeration factors. Results. Technology grant and loan programs and research parks have direct effects on the share of high‐technology employment, along with private venture capital firms and military R&D. Research parks also magnify the effects of private venture capital firms, while public venture programs and technology development policies compensate for agglomeration deficits. Rapid population growth provides a more conducive context for these policies but does not directly influence growth in the share of high‐technology jobs. Conclusion. State and local technology policies compensate for and magnify the effects of agglomeration advantages, indicating that state and local government can play a strategic role in high‐technology development.     

Teaching about near-death experiences: the effectiveness of using The Day I Died

In this article, we reviewed results of research on near-death experiences (NDEs) over the past 3 decades and examined the effect of viewing the hour-long 2002 BBC documentary The Day I Died: The Mind, the Brain, and Near-Death Experiences on accurate knowledge about near-death experiences among advanced undergraduates at a southwestern university. In a quasi-experimental research design, the experimental group completed a 20-item questionnaire before and after viewing the documentary (n = 66; 45 females, 21 males), and the waitlist control group completed the questionnaire as pre- and posttest before viewing the documentary (n = 39; 36 female, 3 male). The two groups' scores at pretest were not significantly different (p > .05). Group by occasion repeated measures ANOVA revealed the experimental group's posttest scores moved significantly in the direction of correctness with a large effect size (p < .001; eta2 = .56), whereas waitlist control group posttest scores remained similar to pretest scores. We discuss two exceptions to the effectiveness of the documentary and recommendations for educators using it as well as for future research.     

Small town renewal

Smalltowners are not as ambivalent about their towns as community developers. This article emphasized the importance of engaging in community analysis — identifying priority problems and needs, and the degree of external penetration; profiling community social, economic, political and value systems while probing the purposes of (re)development. Four distinct orientations — categorical, comprehensive, integrative, and dialogical — are presented. Three orientations were used in an Appalachian town. No one development orientation is the best. Instead, much depends upon how willing; able and how much effort the participants put forth.