TOR pathway: linking nutrient sensing to life span

Recent studies point to an emerging role for the TOR (target of rapamycin) pathway in the regulation of life span. In this Perspective, we discuss the possibility that this pathway is an important modulator of nutrient-dependent changes in life span. Additionally, we discuss the interactions between the TOR and insulin-like signaling pathways as well as the key downstream processes that TOR regulates.     

Characteristics of effective providers of marital and family therapy in rural mental health settings

Characteristics of effective providers of marital and family therapy (MFT) in rural mental health settings were investigated. The survey sample included 74 members of the National Association for Rural Mental Health who, through a modified Delphi process, created a composite picture of effective MFT providers. The findings yielded six major rank-ordered characteristics of effective MFT providers in rural mental health settings, with effective skills in MFT ranked first. Rural community understanding, appreciation and participation ranked second. Specific competencies contributing to each major characteristic were also identified and are discussed. Recommendations for use of this information are provided.     

Everything I needed to know about medical management I learned in acting school

Some people are doctors. Some people play them on TV. Brian Meltzer could probably do both. A physician executive at Memorial Sloan-Kettering Cancer Center, Meltzer relies on skills he learned in acting school to help manage business decisions. In the first of several essays for The Physician Executive, Meltzer explains how acting can help you become a better leader.     

Dimensions of Community Attachment and Their Relationship to Well‐Being in the Amenity‐Rich Rural West*

Abstract This research had two primary objectives: 1) to broaden the sociological construct of community attachment to incorporate both social and natural environment dimensions of attachment, and 2) to examine how variations in attachment relate to two dimensions of well‐being in natural amenity‐rich rural communities. The specific dimensions of well‐being measured are two important factors identified in previous research—collective action and perceptions of open communication. Factor analysis of fourteen measures of attachment indicated social attachment and attachment to the natural environment are distinct dimensions of the broader concept of community attachment. Participation in collective action and perceptions of open communication within a respondent's community explained only a small portion of the variance in levels of both social and natural environment attachment. Religious affiliation and length of residence were strongly associated with social attachment, supporting findings from previous empirical work. However, length of residence and religious affiliation were not statistically associated with levels of attachment to the natural environment, further reinforcing the distinction between the two dimensions of attachment.     

A Two-Phase Exact Algorithm for MAX-SAT and Weighted MAX-SAT Problems

We describe a two-phase algorithm for MAX-SAT and weighted MAX-SAT problems. In the first phase, we use the GSAT heuristic to find a good solution to the problem. In the second phase, we use an enumeration procedure based on the Davis-Putnam-Loveland algorithm, to find a provably optimal solution. The first heuristic stage improves the performance of the algorithm by obtaining an upper bound on the minimum number of unsatisfied clauses that can be used in pruning branches of the search tree.We compare our algorithm with an integer programming branch-and-cut algorithm. Our implementation of the two-phase algorithm is faster than the integer programming approach on many problems. However, the integer programming approach is more effective than the two-phase algorithm on some classes of problems, including MAX-2-SAT problems.     

Cross‐Sectional Psychological and Demographic Associations of Zika Knowledge and Conspiracy Beliefs Before and After Local Zika Transmission

Perceptions of infectious diseases are important predictors of whether people engage in disease‐specific preventive behaviors. Having accurate beliefs about a given infectious disease has been found to be a necessary condition for engaging in appropriate preventive behaviors during an infectious disease outbreak, while endorsing conspiracy beliefs can inhibit preventive behaviors. Despite their seemingly opposing natures, knowledge and conspiracy beliefs may share some of the same psychological motivations, including a relationship with perceived risk and self‐efficacy (i.e., control). The 2015–2016 Zika epidemic provided an opportunity to explore this. The current research provides some exploratory tests of this topic derived from two studies with similar measures, but different primary outcomes: one study that included knowledge of Zika as a key outcome and one that included conspiracy beliefs about Zika as a key outcome. Both studies involved cross‐sectional data collections that occurred during the same two periods of the Zika outbreak: one data collection prior to the first cases of local Zika transmission in the United States (March–May 2016) and one just after the first cases of local transmission (July–August). Using ordinal logistic and linear regression analyses of data from two time points in both studies, the authors show an increase in relationship strength between greater perceived risk and self‐efficacy with both increased knowledge and increased conspiracy beliefs after local Zika transmission in the United States. Although these results highlight that similar psychological motivations may lead to Zika knowledge and conspiracy beliefs, there was a divergence in demographic association.     

Conceptualising the psycho‐emotional aspects of disability and impairment: the distortion of personal and psychic boundaries

Recent feminist critics of the social model of disability have pointed towards a danger that disability studies may give relatively little attention to personal and emotional aspects of disablist oppression and impairment. We argue for consideration of the centrality of the distortion of personal and psychic boundaries as a key aspect of oppressive relational dynamics surrounding disability. Within the observer the disturbing psychic evocations of disability, and related defences, are connected to the maintenance of dynamics of unreal, collusory and alienating modes of relating, which may deprive disabled people of the recognition of subjective experience and personhood. Skewed socialisation of disabled people, involving inter alia the protection of the emotional lives of others, as well as the reality of inaccessible material resources, contributes to the internalisation of disablism and the ideological recruitment of disabled people as complicit in their marginalisation.     

The Effect of Risk Beliefs on Property Values: A Case Study of a Hazardous Waste Site1

Health risk beliefs of homeowners near a landfill site were assessed in a survey and compared to expert judgments of the health risks of living near the site. A bimodal distribution of health risk beliefs suggested sharp disagreement between the experts and at least some of the residents. Correlates of high risk beliefs included perception of odor from the site, exposure to media coverage of the problem, having children living at home, age (younger respondents more concerned), and gender (females more concerned). An aggregated neighborhood health risk belief predicted reductions in home prices even after controlling for home physical characteristics, such as size and other disamenities such as proximity to a freeway. In the 4100 homes near the site, the estimated depression in property values was estimated to total about $40.2 million before the site was closed and to be about $19.7 million after closure. Implications of these results for community conflict and for benefit-cost analysis of hazard site remediation are discussed.