Mitochondrial Dynamics in Cell Life and Death

Mitochondria are dynamic organelles that are able to change their morphology during cellular development and to meet the energetic needs of the cell, for example. During the past several years, knowledge about the molecular machinery involved in the control of mitochondrial shape has improved considerably. In August 2005, leading researchers in the field of mitochondrial dynamics met at the Venetian Institute of Molecular Medicine in Padova, Italy, to discuss novel and intriguing findings presented at the first workshop on "Mitochondrial Dynamics in Cell Life and Death." Some of the findings related to apoptosis and aging are described in this Perspective.     

Global QUALITY OF LIFE (QOL), health and ability are primarily determined by our consciousness. Research findings from Denmark 1991–2004

Objective: To explain the global quality of life (QOL) from 2000 indicators representing all aspects of life. Design and setting: Two cross sectional population studies, one prospective cohort study and one retrospective cohort study. Participants: (1) Representative sample of 2500 Danes (18–88 years), (2) 7222 members of the Copenhagen Perinatal Birth Cohort 1959–1961 (31–33 years), (3) 9.006 mothers and their 8820 children born in Copenhagen 1959–1961, (4) 746 Danes (55–66 years). Main outcome measures: Global QOL measured by SEQOL (self evaluation of QOL) containing eight global QOL measures: Well-being, life-satisfaction, happiness, fulfilment of needs, experience of temporal and spatial domains, expression of lifes potentials and objective factors. Results: 2000 associations; strongest between QOL and health, ability, the personal philosophy of life, the relationships to oneself, the partner and friends; weakest between QOL and 1000 early life factors, 1000 life events and 100 objective factors like income. Conclusions: Quality of life is associated with personal health and attitude towards life, rather than objective factors, life style, or life events. We conclude that QOL can be developed independently and thus be used as medicine.     

Industrial policy: The case for national strategies for world markets

This article considers the objectives of an industrial policy that would develop national strategies for world markets. It describes the tools used to implement such strategies and how the strategies would be organized. The author also considers some of the advantages and disadvantages of developing national strategies for world markets.     

Pooling operators with the marginalization property

In this paper, we consider the problem of combining a number of opinions which have been expressed as probability measures P₁, …, P_n, over some space. It is shown that a pooling formula which has the marginalization property of McConway (1981) must be of the form T = Σⁿ_i=₁W_i P_i + (1 - Σⁿ_i =₁W_i)Q, where Q is an arbitrary measure and W₁, …, W_n ϵ [—1,1] are weights such that| Σ_J Σ _j w_j | ≤ 1 for every subset J of {1, …, n}. If, in addition, T is required to preserve the independence of arbitrary events A and B whenever these events are independent under each P_i, then either T = P_i for some 1 ≤ i ≤ n or T = Q, in which case Q takes values in {0, l}.     

Marriage migration: just another case of positive assortative matching?

It is a stylized fact that marriage formation involves positive assortative matching on education. We also find this in the case of immigrants, even when they tend to “import” their spouses and potentially trade off education for other favorable characteristics. For Pakistanis, we find positive compensating differentials in terms of high education to youth having adopted host country norms, when marrying a marriage migrant. This indicates that Pakistani marriage migrants pay a premium to be able to marry and live in Denmark. For Turks, individuals having source country norms pay a premium in order to import a partner, indicating that unspoiled traditional norms are traded off for education.

The two-sample t test versus satterthwaite's approximate f test

A comparison between the two-sample t test and Satterthwaite's approximate F test is made, assuming the choice between these two tests is based on a preliminary test on the variances. Exact formulas for the sizes and powers of the tests are derived. Sizes and powers are then calculated and compared for several situations.     

Sequential Pattern Analysis: A Statistical Investigation of Sequence Length and Support

In sequential pattern analysis, the frequency of patterns is evaluated by the support. While computed efficiently from large databases, we show that the support cannot be compared between different databases, since it is influenced by the actual sequence length distribution. Models for this sequence length distribution are surveyed. One of these models, the Good distribution, appears to be sufficiently flexible for practice. It is used to exemplify an approach for adjusting the relative support such that the resulting adjusted support values are better comparable between different databases. We illustrate our findings with texts from the bilingual FinDe corpus.     

Kernel density estimation for heavy-tailed distributions using the champernowne transformation

When estimating loss distributions in insurance, large and small losses are usually split because it is difficult to find a simple parametric model that fits all claim sizes. This approach involves determining the threshold level between large and small losses. In this article, a unified approach to the estimation of loss distributions is presented. We propose an estimator obtained by transforming the data set with a modification of the Champernowne cdf and then estimating the density of the transformed data by use of the classical kernel density estimator. We investigate the asymptotic bias and variance of the proposed estimator. In a simulation study, the proposed method shows a good performance. We also present two applications dealing with claims costs in insurance.     

Spatial approaches to social work – theoretical foundations and implications for practice and research

ABSTRACT

Spatial approaches have inspired and grounded the social sciences and social geography already for a longer time. Beyond these models, the theory discourse on social work developed innovative concepts and models of socio-spatial approaches. They set a special focus on aspects of individual and social development, the concept of acquirement and emancipatory approaches to spatial design. For interventions, special methods for socio-spatial analyses were developed. This article reflects the main approaches of this theory discourse and asks for its key implications for social work practice and research.     

Rush and Be Wrong or Wait and Be Late? A Model of Information in Collaborative Processes

Business processes have become more simultaneous and collaborative in the recent past. In simultaneous processes, multiple parties must adapt to one another in real time as decisions evolve. For example, New Product Development (NPD) requires collaboration in the context of Concurrent Engineering, and Supply Chain Management (SCM) in the context of collaborative planning. In both cases, parties must modify decisions based on preliminary information, information that is not fully precise or stable, about what the other parties are doing. This article develops a generalized model of real‐time decision making based on preliminary information, which applies both to NPD and SCM. The model offers insights into when to commit to a course of action, and we derive seven principles that help in dealing with preliminary information.