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11.
The political framework through which the various communities of disabled persons in Cambodia advocate for and claim their rights is complex and confusing. Both governmental and non‐governmental actors engage this political framework through the mobilization of persons from the various disabled communities, competing in the civic sphere through issue‐oriented advocacy in ways that seek to influence the process of democratic governance. While the status of disabled rights in Cambodia is still comparatively weak, it is argued here that this civic engagement has allowed disabled communities to find common cause with non‐disabled persons and groups in the project of deepening the roots of democracy in Cambodia. This article discusses the demographic composition of disability, the framework of political action that addresses disability issues and the practice of civic engagement and activism by disabled and non‐disabled communities in Cambodia.  相似文献   
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Evidence suggests that problem gambling is an unstable state where gamblers move into and out of risk over time. This article looks at longitudinal changes in risky gambling and the factors associated with an increased risk (measured by the Problem Gambling Severity Index [PGSI]) in the current New Zealand context, which has experienced a doubling of the electronic gaming machine (EGM) market over the last two decades. Respondents from a nationally representative baseline sample (n = 2672) were recontacted two years later to assess changes in gambling behaviours. Among the 901 respondents reached at follow-up, average gambling risk increased over time, and the prevalence of those who had at least some level of gambling risk (i.e. low-risk or greater) more than doubled (from 4.7% to 12.4%). The majority (80.2%) of those who were at risk at follow-up had not been at risk at baseline. Multivariate linear regression analyses show that the predictors of low to moderate increased risk include Pacific ethnicity; high neighbourhood deprivation status; baseline frequent, continuous gambler type; baseline PGSI status; and playing EGMs. These findings highlight the need to develop theories of gambling addiction trajectories and to identify the earliest point along the trajectory where public health interventions should occur.  相似文献   
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In Australia, there has been limited research into the issue of the digital divide. Even less attention has been given to the social and spatial characteristics of this phenomenon, particularly within metropolitan areas. This paper attempts to fill this gap by examining the social and spatial characteristics of computer and Internet use in Sydney. The findings suggest that those individuals who are socially and economically disadvantaged have lower rates of computer and Internet use, and that these individuals also risk exacerbating their disadvantage status if these demand-side barriers are not addressed. If we are to address disparities in computer and Internet use in Australia we need to consider more fully the social and spatial nature of such disparities that prevent individuals from accessing such technologies in an increasingly 'wired' world.  相似文献   
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Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). Although the precise physiological function of DJ-1 remains obscure, accumulating evidence suggests that DJ-1 may normally function as a redox-sensitive molecular chaperone that can protect against the deleterious effects of oxidative stress, particularly in mitochondria. Recent studies in the fruit fly, Drosophila melanogaster, have shed further light on the biological role of DJ-1. DJ-1-deficient Drosophila models exhibit distinct phenotypes but collectively highlight a prominent neuroprotective role for DJ-1 against oxidative insult. However, Drosophila lacking DJ-1 do not consistently produce a useful PD-like phenotype (that is, they generally fail to exhibit degeneration of neurons that contain the neurotransmitter dopamine), which may reflect putative compensatory neuroprotective mechanisms. DJ-1-deficient fly models further highlight the utility of Drosophila as an important tool for elucidating protein function and for modeling neurodegenerative disease.  相似文献   
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ABSTRACT

The effect of iwi community justice panels is assessed using data from seven years of implementation. Panel participants of 1013 are compared to a control group drawn from 73,000 offenders charged with similar offences and propensity-matched by age, gender, ethnicity, offending history and location. The dependent measure is re-harm from offending calculated using the NZ Crime Harm Index. Panel participants did not reduce their rate of offending compared to matched controls. However, there is a significant reduction in harm from post-panel offending, on average by 26.9 ± 21.05 equivalised prison days. The relative reduction is 22.25% of the harm committed by matched controls. Iwi panels are an effective alternative justice resolution. Panel participants are found to re-offend with minor offences and thus any focus on rates of offending would miss the complexity of the restorative justice process that reduces the harm of re-offending.  相似文献   
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This article contains a conversation with Robert (Bob) G. Hamlin and is part of aseries that focuses on different human resource development (HRD) scholars. Theaim is to better understand the people behind the names we see in print and at HRD scholarly conferences. Bob is professor emeritus and chair of HRD at the University of Wolverhampton Business School, UK and a management and organization development consultant at Oaken Consultancy. Bob has spoken at many HRD conferences in Europe and the United States and was one of the founding members of the University Forum for HRD. The conversation explores Bob's career in HRD practice, research, teaching and management. Among the topics covered are the significance of practical experience and the influence it can then have on research, the power of evidence-based practice, and the need for HRD research to be seen as relevant and having utility within the world of practice.  相似文献   
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Globalization is a complex process of worldwide changes that brings a great deal of good but is not without its dark side. With corporations having a significant role in globalization, HRD professionals face tough choices about whether and how to be involved.  相似文献   
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