Statistical methodology for assessing homology of intronic regions of genes

We consider the problem of statistically evaluating the similarity of DNA intronic regions of genes. Present algorithms are based on matching a sequence of interest with known DNA sequences in a gene bank and are designed primarily to assess homology among exonic regions of genes. Most research focuses on exonic regions because they have a clear biological significance, coding for proteins, and therefore tend to be more conserved in evolution than intronic regions. To investigate whether the intronic features of genes whose expression is highly sensitive to environmental perturbations differ from genes that have a more constant expression, a collection of oncogenes, tumor suppressor genes, and nonregulatory genes involved in energy metabolism are compared. An analysis of the features of these genes' intronic regions result in clustering by regulatory group. In addition, Billingsley's test for Markov structure (1961) suggests that 67% of the intronic regions in this collection of genes show evidence of nonrandom structure, indicating the possibility of a biological function for these regions. The result of Billingsley's test for homology is used as input to a clustering algorithm. The biological significance of this methodology lies in the identification of groups based on the intronic regions from genes of unknown function. With the advent of rapid sequencing techniques, there is a great need for statistical techniques to help identify the purpose of poorly understood portions of genes. These methods can be utilized to assess the functional group to which such a gene might possibly belong.     

Immigration and status exchange in Australia and the United States

This paper evaluates the status exchange hypothesis for Australia and the United States, two Anglophone nations with long immigration traditions whose admission regimes place different emphases on skills. Using log-linear methods, we demonstrate that foreign-born spouses trade educational credentials via marriage with natives in both Australian and U.S. marriage markets and, moreover, that nativity is a more salient marriage barrier for men than for women. With some exceptions, immigrant spouses in mixed nativity couples are better educated than native spouses in same nativity couples, but status exchange is more prevalent among the less-educated spouses in both countries. Support for the status exchange hypothesis is somewhat weaker in Australia partly because of lower average levels of education compared with the United States and partly because of the less sharply defined educational hierarchy at the postsecondary level.     

The more-than-human sensorium: sensory engagements with digital self-tracking technologies

In this article, we draw on findings from an empirical project involving talking to Australian women about their sensory and sensemaking engagements with digital health technologies. Adopting a new feminist materialist perspective, our analysis identified a series of relational connections, affective forces and agential capacities generated when our participants came together with digitized modes of self-tracking. The agential capacities engendered through and with these technologies included discovering and uncovering information, motivation, quantifying and automating data collection, distinguishing “false” bodily sensations from “real,” discerning patterns, and enhancing sensory capabilities. Working with these technologies, the women were able to access insights into their bodies, feel more in control of bodily activities by reflecting on this information and any patterns over time it revealed. The limitations of these sensory devices were also revealed in the women’s accounts. The devices sometimes closed off or challenged women’s sensory knowledge in ways they found less than useful or helpful, due to failings in the devices’ design or functionality. Our analysis, therefore, highlights the intra-action of enactments of human sensory responses as they engage with digital devices and digital data, including the ways in which these responses were extended, facilitated, or, in some cases, challenged.     

Is Asian ethnicity an independent risk factor for severe perineal trauma in childbirth? A systematic review of the literature

ObjectiveTo undertake a systematic review of the literature to determine whether Asian ethnicity is an independent risk factor for severe perineal trauma in childbirth.MethodOvid Medline, CINAHL, and Cochrane databases published in English were used to identify appropriate research articles from 2000 to 2010, using relevant terms in a variety of combinations. All articles included in this systematic review were assessed using the Critical Appraisal Skills Programme (CASP) ‘making sense of evidence’ tools.FindingsAsian ethnicity does not appear to be a risk factor for severe perineal trauma for women living in Asia. In contrast, studies conducted in some Western countries have identified Asian ethnicity as a risk factor for severe perineal trauma. It is unknown why (in some situations) Asian women are more vulnerable to this birth complication. The lack of an international standard definition for the term Asian further undermines clarification of this issue. Nevertheless, there is an urgent need to explore why Asian women are reported to be significantly at risk for severe perineal trauma in some Western countries.ConclusionCurrent research on this topic is confusing and conflicting. Further research is urgently required to explore why Asian women are at risk for severe perineal trauma in some birth settings.     

The Slope of Change: An Environmental Management Approach to Reduce Drinking on a Day of Celebration at a US College

Abstract

Objective: This research extends the literature on event-specific environmental management with a case study evaluation of an intervention designed to reduce student drinking at a university's year-end celebration. Participants: Cornell University undergraduates were surveyed each May from 2001 through 2009. Sample sizes ranged from 322 to 1,973. Methods: Randomly sampled surveys were conducted after a large, annual spring campus celebration. An environmental management plan was initiated in 2003 that included increased enforcement of the minimum legal drinking age (MLDA) law. Results: In the short term, drinking at the campus celebration decreased while drinking before the event increased. Over time, the intervention significantly reduced high-risk drinking on the day of the event, especially among those under the age of 21. Conclusion: These findings are contrary to the argument that enforcement of MLDA laws simply leads to increased high-risk drinking, and therefore have implications for how colleges approach the challenge of student alcohol misuse.     

“My nest is full:” Intergenerational relationships at midlife

Incorporating a life course perspective, this qualitative study used focus groups to explore the experiences of midlife adults who were simultaneously providing support to emerging adult children and aging parents. Results indicated that adults situated in middle generations held beliefs that endorsed family-based responsibility to both younger and older members. Parents gladly supported children despite their longer transition to adulthood. Often unanticipated but accepted, provisions of care to aging parents were experienced with ambivalence — a joy and a burden. The transition of their parents to greater dependence helped participants gain insights into the terrain of late life and encouraged reflections about the intersection of aging, independence, and family responsibility. Participants expressed intentions to preserve their own independence and spare their children of caregiving burdens through self-directed actions. Implications focused on negotiations of family relationships around issues of independence and family responsibilities as a way to reduce intergenerational ambivalence.     

Multiple Disadvantages Among Older Citizens: What a Multidimensional Measure of Poverty Can Show

Using the newly created Freedom Poverty Measure, a multidimensional measure of poverty, it can be seen that there were 534,700 individuals who were in freedom poverty, who had either poor health or poor education in addition to having low incomes. This multidimensional disadvantage would not normally be captured by single measures of poverty, such as income poverty measures. Men were significantly less likely to be in freedom poverty than women (OR = 0.63, 95% CI: 0.54–0.74, p < .0001), and the proportion of individuals in freedom poverty increased with age, with those older than 85 being 2.3 times more likely to be in freedom poverty than those aged 65 to 69 years (95% CI: 1.73–3.11, p < .0001). Policy responses to address the marginalization of disadvantaged older people should take a multidisciplinary approach, addressing health inequalities in particular, not just low income.     

Designing a Faculty Development Program on Technology

This article illustrates the challenges of creating a faculty development program on technology through the presentation of experiences with one such program, the Virtual Guild. Using examples from the Virtual Guild, the authors focus on the areas of program design and faculty motivation. The discussion of program design involves selecting content and determining the program format. Motivational issues discussed include individual- and organizational-level factors, as well as the combined effect of these factors on faculty participation.     

Differences in Views of Family Life According to Age,Gender, and Parental Marital Status

A sample (N = 706) of children, adolescents, young adults, and older adults were surveyed with regard to their views of family. Young adults endorsed more nontraditional views than children and older adults and were more likely than other age groups to indicate that there is no best family type. Children and older adults were more likely than adolescents and young adults to endorse married or living together parents as the best family type. Women and respondents who had experienced parental divorce endorsed traditional views of family less strongly, but women also endorsed stronger expectations for their own family formation. Findings support the possibility of both developmental and sociocontextual influences on attitudes toward family life.