Comparison of dichotomized and distributional approaches in rare event clinical trial design: a fixed Bayesian design

This research was motivated by our goal to design an efficient clinical trial to compare two doses of docosahexaenoic acid supplementation for reducing the rate of earliest preterm births (ePTB) and/or preterm births (PTB). Dichotomizing continuous gestational age (GA) data using a classic binomial distribution will result in a loss of information and reduced power. A distributional approach is an improved strategy to retain statistical power from the continuous distribution. However, appropriate distributions that fit the data properly, particularly in the tails, must be chosen, especially when the data are skewed. A recent study proposed a skew-normal method. We propose a three-component normal mixture model and introduce separate treatment effects at different components of GA. We evaluate operating characteristics of mixture model, beta-binomial model, and skew-normal model through simulation. We also apply these three methods to data from two completed clinical trials from the USA and Australia. Finite mixture models are shown to have favorable properties in PTB analysis but minimal benefit for ePTB analysis. Normal models on log-transformed data have the largest bias. Therefore we recommend finite mixture model for PTB study. Either finite mixture model or beta-binomial model is acceptable for ePTB study.     

The Epistemic Culture of Homebrewers and Microbrewers

Homebrewing and microbrewing have been growing in popularity during the last few decades. One way this phenomenon can be analyzed is through the culture of knowledge production. We use the subfield of science and technology studies (STS) to examine homebrewing and microbrewing in this light. Early STS was interested in the social construction of scientific facts within daily practices of scientists. Through these early studies, STS revealed not only the process of scientific fact creation but also existence of “epistemic cultures.” Our study investigates the epistemic culture of homebrewers and microbrewers. Analysis of this epistemic culture was accomplished through use of in-depth interviews with homebrewers and microbrewers at several regional sites. Three major themes emerged from the data: home space as lab; the art and science of beer brewing; and brewing as “friendship”. These themes establish a foundation for understanding the shared epistemic culture existing between homebrewers and microbrewers.     

The NIP graph of a social welfare function

We consider the fraction of pairs of m distinct alternatives on which a social welfare function f may be nondictatorially independent and Pareto when the domain of f satisfies the free k-tuple property. When k = 4 we improve the existing upper bound to . When there are at least 26 alternatives and we obtain an original upper bound, . To obtain these results we define and analyze the graph formed from the nondictatorial independent and Pareto pairs and combine the results of this analysis with known results from extremal graph theory. The authors extend special thanks to the two reviewers and the editor for their comments.     

Education and survival: Birth cohort,period, and age effects

Previous studies have found that educational differences in mortality are weaker among the elderly. In this study I examine whether either cohort or period effects may have influenced the interpretation of age effects. Six 10-year birth cohorts are followed over 30 years through decennial censuses. Differential survival is inferred from changes in the relative proportions of a cohort in each education category as the cohort ages. In cross-section, younger persons generally show stronger education effects on survival, although this pattern is clearer for women than for men. There is evidence of period effects. Within cohorts, relative survival tends to increase with age.     

Powerblindness

In the land of the blind, the one‐eyed man may be king. But positions of power may produce their own forms of blindness. This paper reviews multiple theoretical approaches to the concept of powerblindness and categorizes these literatures into five forms through which powerblindness operates: powerblind identity (failure to notice that one belongs to a privileged group), powerblind egalitarianism (belief that all groups are equal in power), powerblind hierarchy (emphasis on one's own subordinate position), powerblind exception (the claim that one is less privileged than others in one's group), and powerblind justification (belief that present‐day hierarchy is merited or inevitable). The paper identifies studies offering evidence for each, drawing on social‐psychological experiments, survey data, and qualitative research, suggesting that power and knowledge do not necessarily go hand in hand – some forms of knowledge about the social order may be more visible to people with less power than to people with more.     

Prevention of child abuse and neglect and improvements in child development

The aim of the study was to evaluate the implementation of a section in the Danish Social Assistance Act which encourages local authorities to offer families services in order to support children at risk of child maltreatment. The specific purpose of the present paper is to answer the question: Will the socio‐psychological development of children known to social services be improved when abuse and neglect are reduced? A sample of 1,138 children was drawn at random from new social services cases starting in 1998. Subsequently, about 80 per cent were evaluated by local caseworkers on the basis of a standardised questionnaire covering a period of four years. The most damaging family conditions seemed to be psychological maltreatment, physical/sexual abuse and neglect. Maltreated children were more often in a depressed state, unhappy, socially isolated, or they had an eating disorder, inadequate or under‐nutrition, suicidal tendencies, lack of concentration, or disturbed behaviour, compared to those children who were not exposed to abuse and neglect. If parental behaviour improved, effects on children's well‐being were also observed and positive changes in children's socio‐psychological development were identified. The questionnaire explored the impact of various interventions, including services geared to strengthen the child's network, but results indicated that the child displayed reduced risk of reactive symptoms only when parental behaviour improved and abuse and neglect were reduced. Copyright © 2009 John Wiley & Sons, Ltd.     

Developmental Trajectories of Emotion Regulation Across Infancy: Do Age and the Social Partner Influence Temporal Patterns

The ability to effectively regulate emotions is a critical component of early socio‐emotional development. This longitudinal study examined the developmental trajectories of emotion regulation in a sample of 3‐, 5‐, and 7‐month‐olds during an interaction with mothers and fathers. Infants' negative affect and use of behavioral strategies, including distraction, self‐soothing, and high intensity motor behaviors were rated during the still‐face episode of the Still‐Face Paradigm. Longitudinal mixed‐effects models were tested to determine whether strategies were followed by an increase or decrease in negative affect. Results from mother‐infant and father‐infant dyads indicated that focusing attention away from the unresponsive parent and engaging in self‐soothing behaviors were associated with a subsequent decline in negative affect and the strength of these temporal associations were stable across infancy. In contrast, high‐intensity motor behaviors were followed by an increase in negative affect and this effect declined over time. No significant effects were found for the behavioral strategy of looking at the parent. Results underscore the importance of considering infant age and the social partner when studying the effectiveness of emotion regulatory strategies in early infancy.     

Public sociability of college‐aged male homosexuals: The gay bar and cruise block

The young, overt, college‐aged male gay community (17 to 24 age group) is examined by focusing on its public sociability. The values of this community, its locale, and its youthful members give this study unique qualities and characteristics which are distinguished from other research efforts that have predominantly focused on sociability from the perspective of the large urban, secret middle‐class older gay community. Nearly all sociability among these young gays occurs at a gay bar. The various functions of the gay bar and its major facilitators of sociability (drugs and special events) are illustrated. In addition, the cruise block, primarily utilized for exchanges of conversation and secondarily for the seeking of impersonal sex, is analyzed.     

Engendering Government Budgets in the Context of Globalization(s)

This article considers the strengths and weaknesses of attempts to 'engender' government budgets in the context of globalization, drawing on my own personal engagement in such attempts, and on the work of many gender budget initiatives (GBIs) all around the world. GBIs have sought to improve the distribution, adequacy and impact of government budgets at national, regional and local levels; and to secure greater transparency in the use of public money; and greater accountability to women as citizens. Their spread has itself been an example of globalization, in this case the globalization of action for gender justice; facilitated by e-mail, the Internet and air travel; supported by international foundations and international development cooperation funds. But, it may be argued, GBIs have begun to engage with government budgets just at the time when governments, especially in the South, have less and less control over public finance decisions, due to other aspects of globalization. This article considers whether there is any point in GBIs if economic power lies in international markets, rather than in the Ministry of Finance, and draws on examples from a wide variety of countries.