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51.
52.
Erectile dysfunction (ED) is one of the most common disorders in male and is often associated with other age-related comorbidities. The aging process affects the structural organization and function of penile erectile components such as smooth muscle cell and vascular architecture. These modifications affect penile hemodynamics by impairing cavernosal smooth muscle cell relaxation, reducing penile elasticity, compliance and promoting fibrosis. This review aims to identify the mechanisms of ED in the penile aging process in experimental and clinical data. It also highlights areas that are in need of more research. The search strategies yielded total records screened from PubMed. Clarification of the molecular mechanisms that accompanies corpus cavernosum aging and aging-associated ED will aid new perspectives in the development of novel mechanism-based therapeutic approaches. Age is not a limiting factor for ED medical management, and it is never too late to treat. Hypogonadism should be managed regardless of age, and synergistic effects have been found during testosterone (T) replacement therapy when used along with oral phosphodiesterase-5 (PDE-5) inhibitors. Therefore, the clinical management of ED related to aging can be done by therapeutic interventions that include PDE-5 inhibitors, and other pharmacological treatments. 相似文献
53.
Correlated data are commonly analyzed using models constructed using population-averaged generalized estimating equations (GEEs). The specification of a population-averaged GEE model includes selection of a structure describing the correlation of repeated measures. Accurate specification of this structure can improve efficiency, whereas the finite-sample estimation of nuisance correlation parameters can inflate the variances of regression parameter estimates. Therefore, correlation structure selection criteria should penalize, or account for, correlation parameter estimation. In this article, we compare recently proposed penalties in terms of their impacts on correlation structure selection and regression parameter estimation, and give practical considerations for data analysts. Supplementary materials for this article are available online. 相似文献
54.
Sowmya Rajan S. Philip Morgan Kathleen Mullan Harris David Guilkey Sarah R. Hayford Karen Benjamin Guzzo 《Population research and policy review》2017,36(6):903-928
Having an unintended birth is strongly associated with the likelihood of having later unintended births. We use detailed longitudinal data from the Add Health Study (N = 8300) to investigate whether a host of measured sociodemographic, personality, and psychosocial characteristics select women into this “trajectory” of unintended childbearing. While some measured characteristics and aspects of the unfolding life course are related to unintended childbearing, explicitly modeling these effects does not greatly attenuate the association of an unintended birth with a subsequent one. Next, we statistically control for unmeasured time-invariant covariates that affect all birth intervals, and again find that the association of an unintended birth with subsequent ones remains strong. This persistent, strong association may be the direct result of experiencing an earlier unintended birth. We propose several mechanisms that might explain this strong association. 相似文献
55.
Social work educators are responsible for ensuring that future practitioners are culturally competent and have the ability to work effectively with people from different backgrounds. The purpose of this article is to address the current limitations in measuring cultural competence and to report the results of a qualitative study examining stakeholders’ conceptualizations of the definition, educational process, and evaluation of cultural competence in social work education. Findings support long-standing assumptions in the literature regarding the need for social workers to develop certain knowledge and attitudes as prerequisites of becoming culturally competent, and emphasize the need for further exploration of the way social workers define cultural competence, translate it into discrete practice behaviors, and assess how students demonstrate these behaviors. 相似文献
56.
Young graduates in England often return to the parental home after a period of living away during their university studies. Little is known, however, about why they return and how coresidence with parents fits within a life trajectory. This paper reports upon an in-depth cross-sectional qualitative study of young graduates’ coresidence with their parents. It identifies a five-part typology of the purpose of coresidence as perceived by the graduates: a base camp for exploration before settling into adulthood; a launch pad for careers; a savings bank, in particular for future property purchases; a refuge for respite and reflection; and a preferred residence, whether on account of comfort, cultural practice or to support parents. The paper further explores how far these purposes were associated in young adults’ accounts with social structures, individual agency or some combination of these. It concludes that the default understanding of graduates’ return and coresidence as a residual function when other options fail is insufficient. Such a generalisation obscures the different purposes which the return can enable; it overplays some notion of a broken biography rather than the positive contribution of coresidence to graduates’ trajectories towards adulthood and to their life experiences. 相似文献
57.
Philip Kasinitz 《Sociological Forum》2012,27(3):579-590
Controversies about international migration expose the changing structure of and underlying assumptions about societal membership in many nations. The sociology of international migration has emerged as an increasingly important subfield over the past decade in large part because it has tended to move beyond more narrow economic and demographic problems and has begun to address this fundamentally sociological issue. In the future it will be particularly important that sociologists pay attention to how demographically changing societies define who is and is not a member. As such, legal status and the role of the state has become critically important. 相似文献
58.
Does Higher Education Cause Religious Decline?: A Longitudinal Analysis of the Within‐ and Between‐Person Effects of Higher Education on Religiosity
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Philip Schwadel 《The Sociological quarterly》2016,57(4):759-786
Although there is ample empirical evidence of the associations between higher education and various aspects of religiosity, the causal mechanisms producing these associations remain unclear. I use four waves of longitudinal data, with respondents ranging in age from 13 to 29, to model the within‐ and between‐person effects of higher education on several measures of religiosity. The results show that earning a bachelor's degree is associated with within‐person declines in some but not all measured aspects of religiosity, which partially supports the argument that higher education causes religious decline. The results also suggest that those predisposed to attending religious services self‐select into higher education, that relatively religious youth in general self‐select into nonelite colleges, and that those with low levels of religious belief self‐select into elite universities. These findings further understanding of the associations between social class and religion, particularly the causal effects of higher education. 相似文献
59.
Elissa E. Madden Amy Chanmugam Ruth G. McRoy Laura Kaufman Susan Ayers-Lopez Mary Boo Kathleen J. Ledesma 《Child and Adolescent Social Work Journal》2016,33(6):523-534
This paper reports the results of a quantitative 42-item survey that explored foster, adoptive, and kinship parents’ (N = 160) utilization of different types of respite services (formal, informal, and a mixture of formal and informal), as well as their impressions of the impact of respite care on aspects of their lives related to family cohesion and stability, caring for their children, and their personal wellbeing. An exploratory cross-sectional, survey design was used to assess both the formal and informal respite care experiences of the foster, adoptive, and kinship caregivers. Two-tailed Fisher’s exact tests were used to examine the relationship between the type of respite received and caregivers’ respite experiences. Findings indicated that parent experiences differed depending on the type of respite services they received. Specifically, parents who used a mixture of formal and informal respite reported positive experiences related to respite more frequently than the other two types of respite groups, while those who received only informal respite reported less benefit than others. Parents who used formal respite (either alone or mixed with informal respite) reported greater stress reduction. The greatest increase in family stability was reported by parents who received a mix of informal and formal respite. While this study revealed clear benefits for families to using both informal and formal respite services, the findings suggest that formal respite care was helpful to parents regardless of whether used alone or in combination with informal care. 相似文献
60.
Using data for U.S. counties from 2005 to 2012, we test whether higher levels of economic diversity mediated the effects of the Great Recession via four measures of stability. Spatial spillover effects are modeled by the use of the spatial Durbin estimator with heteroscedastic errors. The data generally support the central hypothesis that higher levels of diversity within a county are associated with enhanced employment stability across all counties as well as subsets of metro and nonmetro counties. Results for wage stability, however, appear to contradict our other findings. We suggest that underlying labor elasticities can bridge these apparent contradictory results. (JEL R11, R12, O47) 相似文献