PI3K pathway and Bcl-2 family. Clinicopathological features in prostate cancer

The phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathways and Bcl-2 family play a central role in prostate cancer (PC). The aim was to determine influence in the biochemical progression in PC. To evaluate the association between clinic pathological and immunohistochemical variables, Spearman’s test was performed. Log-rank test and Kaplan–Meier curves were used for survival comparisons. To explore the correlation of the studied immunohistochemical parameters and the established prognostic variables with biochemical progression, univariate and multivariate Cox proportional Hazard regression analyses were performed. Spearman analysis showed correlation between stroma expression and tumor expression of PI3K with biochemical progression (p?=?.009, p?=?.004), respectively, and tumor immunohistochemical score with biochemical progression (p?=?.051). In the multivariate Cox regression model, only PI3K was retained as independent predictors of biochemical progression. In stroma expression, PI3K is (HR 0.172, 95% CI 0.065–0.452, p?=?.000); tumor expression, PI3K is (HR 0.087, 95% CI 0.026–0.293, p?=?.000), and tumor immunohistochemical score (HR 0.382, 95% CI 0.209–0.697 p?=?.002). Our results suggest a role for prostatic expression of PI3K was prognostic markers for PC. PI3K/AKT/mTOR and Bcl-2 family are becoming an important therapeutic target and predictive biomarkers of onset and progression of PC.     

Identifying beliefs behind boys’ use of mobile phones to monitor girlfriends and girls’ acceptance: a reasoned-action approach

Monitoring/controlling behaviours can be present in the early stages of an abusive relationship. Because of the need for evidence-based interventions grounded on behavioural models that identify the determinants of abusive behaviours, we applied the formative research of the reasoned action approach to: (1) conduct an elicitation study on the behavioural and normative beliefs that explain why boys use mobile phones to monitor their girlfriends and why these accept it, (2) analyse the items designed to assess the different constructs in the model and (3) carry out a preliminary exploration of the relationship between constructs. The sample was composed of 119 adolescent girls and boys between 14 and 18 years of age. Boys and girls seem to hold complementary beliefs that could produce a feedback loop that maintains the abusive behaviour. Parents are a protective factor against the behaviour whereas peers are not. Results on the item analysis and reliability of the scales were good. Intention seems an important predictor of the performance (51%) and acceptance (60%) of the behaviour and attitudes and perceived social norms of the intention (boys: 67%; girls: 65%), which suggests the appropriateness of the model for the prediction of the behaviour.     

Twitter and video activism as tools for counter-surveillance: the case of social protests in Spain

From a communication perspective, social movements of international significance such as the Arab Spring, Toronto G20, Spanish 15M or Occupy Wall Street have been characterized by the use of mobile communication and social media as tools for video activism and counter-surveillance against the abuse of power committed by the state forces. A representative case of this reality, which reached a high coverage and support in social media environment, can be found in the riots that took place in the Gamonal neighbourhood (Burgos, Spain) in January 2014. In this regard, this article focuses on the denunciation of police violence through video activism by Twitter users during the demonstrations across the country, applying a quantitative–qualitative mixed methodology. First, by means of a content analysis, a sample of 784 tweets linked to videos is analysed in order to identify the main topics and functions of the shared content. Second, a textual analysis of those linked videos of a violent nature recorded by witnesses in order to document police interventions is carried out. The prominent use of Twitter for distributing videos to denounce police violence stands out among the main findings, underlining the audiovisual exposure and ‘secondary visibility’ of the police officers. The results obtained also reinforce the idea of citizen empowerment through the development of an alternative form of journalism, as a practice to criticize the mainstream media coverage of the protests. Additionally, this article sheds light on the open debate about the relevance of social media to encourage citizen involvement in a face-to-face interaction.     

How do vulnerable youth complete secondary education? The key role of families and the community

This article demonstrates how the engagement of families and other community members in decision-making processes in a school may prevent early school leaving among vulnerable youth and simultaneously increase their enrolment in secondary education. Based on a large-scale, EU-funded study, this article focuses on the case of one school located in a deprived area inhabited mainly by Roma people – one of the vulnerable populations most affected by early school leaving – where a specific egalitarian participatory process of Roma families was implemented. According to the analysis of the collected data, this participation contributed to a reduction in student dropout rates during primary education, led to the implementation of compulsory secondary education in the same school, and increased the numbers of students who graduated from secondary school. These achievements transformed the educational and social prospects of vulnerable youth who were following the path to failure and who now dream of continuing their studies. Furthermore, these youth are acting as role models for younger children in primary education, helping to prevent school dropout and early school leaving from early ages. The case shows how the community participation in decision-making processes transformed the climate and expectations regarding education in the neighbourhood.     

Evaluation of job satisfaction in a sample of Spanish social workers through the ‘Job Satisfaction Survey’ scale

The objective of this study is to determine the level of job satisfaction experienced by social workers and to establish whether there are significant differences between the various levels of job satisfaction and a series of personal features and job characteristics. The participants were 947 social workers (861 women and 86 men) belonging to 35 of the 36 Professional Associations existing in Spain. The measurement tool used is the Job Satisfaction Survey scale, designed by Spector [2002. Psicología Industrial y Organizacional: Investigación y Práctica [Industrial and organizational psychology: Research and practice]. México: Manual Moderno]. The results show that the social workers surveyed experience moderate levels of job satisfaction (M?=?115.8; SD?=?21.4). The intrinsic factor that seems to have the greatest positive influence on job satisfaction is the nature of the job, while the extrinsic factors of pay, fringe benefits, and operating conditions are the ones that contribute most to job dissatisfaction, and social workers have no control over any of them.     

Researching the links between social-emotional learning and intercultural education: strategies for enacting a culturally relevant teaching

ABSTRACT

This paper examines the links between social-emotional learning (SEL) and intercultural education. The work calls for pedagogical attention to the role of emotions in intercultural education and analyses the role of SEL within the umbrella of intercultural education. It claims that both SEL and intercultural education offer a framework for rethinking and changing curricula, school climates and relationships providing the foundation for quality of education for all. Therefore, this connection is not only critical but also inevitable and desirable. It asserts that SEL in intercultural landscapes is a human right that all students are entitled to, and argues that ignoring this right amounts to a social injustice. Some pedagogical considerations and strategies for enacting a culturally relevant implementation of SEL in intercultural settings will be provided. The purpose of the paper is to inform the debate on the role of emotional aspects in intercultural education, and how to configure culturally responsive teachers.     

The impact of R&D sources on new product development: Sources of funds and the diversity versus control of knowledge debate

We build on the knowledge-based view to study the relative impact of alternative R&D sources on innovation performance. We contrast two arguments that have created a debate in the literature: One is that diversity of knowledge is better for innovation, because the integration of a larger variety of knowledge helps create new products that can fulfill unmet customer needs; another is that control of knowledge is better, because the incentives and contextual system of the firm facilitate employees' experimentation, which supports the creation of new products. We provide one solution to this debate by arguing that the relative importance of diversity and control of knowledge on innovation depends on the sources of finance. Hence, we find that, in general, control of knowledge has a higher impact than diversity of knowledge on the sale of new products. We also find that alternative sources of finance moderate the relationships: internal funds strengthen the impact of R&D sources with more diversity of knowledge on the sale of new products, while external funds strengthen the impact of R&D sources with more control of knowledge on the sale of new products.     

Importance of fairness in humanitarian relief distribution

Abstract

This article is inspired by some of the challenges faced by non-governmental organizations in the distribution of humanitarian relief to vulnerable rural communities. A major concern of these organizations is to warrant that relief is distributed in an impartial and transparent way, which gives rise to the notion of fairness. This article thus discusses the importance of fairness in relief distribution and how it can be defined, especially in a context where delivery of vital items must be ensured periodically. We also propose some performance indicators to measure fairness, which can be useful to organizations that are held accountable for the impartiality of their decisions. Finally, an empirical study of an academic case, inspired by a rural aid distribution problem, is used to analyse how different mathematical formulations may contribute in helping crisis managers integrate fairness or equity in their decisions.     

Computing the <Emphasis Type="Italic">k</Emphasis>-resilience of a synchronized multi-robot system

The vertex arboricity va(G) of a graph G is the minimum number of colors the vertices can be colored so that each color class induces a forest. It was known that \(va(G)\le 3\) for every planar graph G. In this paper, we prove that \(va(G)\le 2\) if G is a planar graph without intersecting 5-cycles.