发展适用于活体细胞中RNA分析和成像的新型分子信标

很多研究采用分子信标技术来作为活体细胞中RNA表达研究的成像手段。然而,越来越多的证据表明,由于该技术易产生假阳性信号使得RNA的检测灵敏度显著降低。本文就如何克服这些缺陷,实现活体细胞中RNA的高灵敏检测来构建分子信标进行了阐述。     

文学与文化——以欧洲文学与欧洲文学史研究为例

本文探讨了文学与文化的关系问题,强调文化的整体性和有机性以及文化传统的历史影响,主张文学与文学史的研究必须在相应的文化传统的框架里进行。作者以欧洲文学和文学史研究为例,指出缺乏欧洲文化传统整体意识的文学研究往往容易使研究成果沦为地理与时间的碎片。     

Intergenerational Ties in Context: Grandparents Caring for Grandchildren in China

Guided by theories and empirical research on intergenerational relationships, we examine the phenomenon of grandparents caring for grandchildren in contemporary China. Using a longitudinal dataset (China Health and Nutrition Survey), we document a high level of structural and functional solidarity in grandparent-grandchildren relationships. Intergenerational solidarity is indicated by a high rate of coresidence between grandchildren and grandparents, a sizable number of skipped-generation households (no parent present), extensive childcare involvement by non-coresidential grandparents, and a large amount of care provided by coresidential grandparents. Multivariate analysis further suggests that grandparents' childcare load is adaptive to familial needs, as reflected by the characteristics of the household, household members, and work activities of the mothers.     

A mixed method study of propensity for participatory evaluation

One way to increase the use of evaluation results is practical participatory evaluation (PPE), which enables non-evaluator participants to join the evaluation process in a participatory mode. We examined the propensity for PPE of health professionals by focusing on four components: learning, working in groups, using judgment and using systematic methods. We interviewed the professionals at a Haitian health institution to determine their positioning on a scale of propensity (low, medium and high) for the four components. The professionals defined each component in relation to the energy puts into them, being more or less proactive. Facilitating elements for all three levels of propensity integration included past positive experiences, external pressure and a desire for better individual and organizational performance. Impeding factors included a lack of available resources perceived responsibilities and commitments toward private patients. The reported advantages included improved organizational performance and idea sharing, and the disadvantages included availability of, difficulty implementing solutions and altered human relationships.     

Acquisition of cross-ethnic friends by recent immigrants in Canada: a longitudinal approach

This paper examines the development of inter-ethnic friendships between immigrants and Canadians. It uses longitudinal data from three waves of the Canadian LSIC survey, in which newly arrived immigrants were followed during the first 4 years of settlement. It is found that pre-migration characteristics play an important role in the development of inter-ethnic friendships: immigrants who arrive at a younger age and for economic reasons, as well as those who are highly educated and have a cross-ethnic partner at the moment of arrival, establish more inter-ethnic friendships over time. In addition, post-migration characteristics affect the formation of inter-ethnic friendships. Such friendships are more common among immigrants who embrace Canadian traditions and acquire the host-country language, as well as among those who work in international settings and inhabit ethnically mixed neighborhoods. The effects of pre-migration characteristics are partially mediated by post-migration characteristics. Our findings point out that economic, cultural, and spatial integration are all conducive to inter-ethnic friendships.     

Outcomes of parental mental illness on children: a qualitative study from Iran

Children of parents with mental illness are a substantial, yet marginalized group. This study, as part of a more extensive research project, used grounded theory to explore the outcomes of parental mental illness on their children. Seventeen informants were interviewed at a mental hospital in the city of Qazvin, Iran. The participants were selected using purposeful and theoretical sampling. Interviews were analyzed using Strauss and Corbin's method. It was revealed that parental mental illness leads to five major outcomes that involve communication, mental, educational, economic, and extra roles factors. As such, it is suggested that these children should be considered within health care plans and that policy makers, nurses, and other health care providers use these findings for preventive and educational purposes.     

Sexual abuse allegations by children with neuropsychiatric disorders

All Swedish court cases from 2004 and 2006 concerning alleged child sexual abuse (sexual harassment excluded) were identified through criminal registers. Fourteen cases (one boy) concerned a child with a neuropsychiatric disorder. The diagnostic groups were mental retardation (10 cases), autism (three cases), and ADHD (one case). Psychiatric experts were engaged in only two cases. When experts were involved, the courts focused on credibility issues. When the courts applied neuropsychiatric arguments in the absence of an expert, they used developmental arguments. When the authors found that significant neuropsychiatric issues were not discussed by the court it concerned interpretations of symptoms and developmental standpoints. The results illustrate the complexity and pitfalls of drawing conclusions about associations between symptoms and personality characteristics on one side and accuracy of sexual abuse allegations on the other. Moreover, the results highlight the importance of a high quality system for providing courts with adequate neuropsychiatric knowledge.     

Attributions about Addiction among Latina Women

This cross-sectional, secondary analysis study utilizes data from a prior study of intergenerational substance use among Latina women (n = 316). We explored the influence of substance use frequency and type, as well as cultural and socioeconomic factors on attributions about addiction among a predominantly immigrant sample of Latina women. Women who were less proficient in English (an indicator of adoption of the receiving culture in the acculturation process) and more proficient in Spanish (an indicator of heritage-culture retention) endorsed more spiritual model attributions than women who were more proficient in English and less proficient in Spanish. Women were more proficient in Spanish more frequently endorsed the disease attribution model. Alcohol, marijuana use and non-medical sedative use were linked with spiritual, moral /character and disease attribution models respectively. Participants reporting higher education levels indicated less agreement with the moral/character model of addiction. Implications for culturally tailored social work interventions for Latina women are discussed.