An information-theoretic approach to surrogate-marker evaluation with failure time endpoints

Over the last decades, the evaluation of potential surrogate endpoints in clinical trials has steadily been growing in importance, not only thanks to the availability of ever more potential markers and surrogate endpoints, also because more methodological development has become available. While early work has been devoted, to a large extent, to Gaussian, binary, and longitudinal endpoints, the case of time-to-event endpoints is in need of careful scrutiny as well, owing to the strong presence of such endpoints in oncology and beyond. While work had been done in the past, it was often cumbersome to use such tools in practice, because of the need for fitting copula or frailty models that were further embedded in a hierarchical or two-stage modeling approach. In this paper, we present a methodologically elegant and easy-to-use approach based on information theory. We resolve essential issues, including the quantification of “surrogacy” based on such an approach. Our results are put to the test in a simulation study and are applied to data from clinical trials in oncology. The methodology has been implemented in R.     

Risk,resilience and identity construction in the life narratives of young people leaving residential care

The role of residential care for children has developed very differently internationally, but in all cultural contexts, there are questions about the extent to which it can help young people recover from high risk backgrounds. In the UK, residential care has come to be seen as the placement of last resort, yet new government guidance on permanence has suggested that residential care can provide security and a sense of belonging. Narrative analysis of interviews with 20 care leavers identified their different pathways from birth families through residential care to early adulthood. Some experienced a transformation from a negative sense of self as victims or ‘bad children’ to survivors, while others continued to struggle. Key to successful turning points were four interacting factors, all associated with resilience; connection, agency, activity and coherence. These narratives revealed the importance of nurturing relationships and a sense of ‘family’, and also the role of support after leaving residential care, when transitions workers helped them to move on but stay connected. The study highlighted how residential care leavers from adverse backgrounds attribute very different meanings to their experiences, which affects identity construction, resilience and the need for support.     

From communication to co‐operation: Reconceptualizing social workers' engagement with children

Communicating and engaging with children is a foundational component of child care social work practice, but all too frequently, in the wake of serious incidents, it is the focus of criticism. Drawing on findings from a large‐scale ESRC‐funded research project conducted in the four U.K. nations, this paper explores, through a psychosocial analytic lens, how social workers anticipate, enact and reflect on their encounters with both children and their families. Close analysis of what social workers said about their practice alongside what they were observed to do in practice revealed perceptions, patterns and processes of communication that, first, minimize emotions and the complexity of the professional task and second, overly privilege verbal interaction. Drawing on Sennett's (2012) ideas this paper offers a reconceptualisation of this professional task, from a communicative to a co‐operative one. It affords and creates a space in which social workers can develop more attuned communicative practices that include rituals, gestures and the minimal use of force. The theoretical insights and evidence‐informed practice recommendations arising from this research have conceptual significance for the social work discipline and practical significance for the child care social work profession, across national and international contexts.     

Innovative Social Policies: Implications for Work–life Balance among Low‐waged Women in England

We investigated innovative social policies drawn from the European arena — universal systems of childcare, a shorter working week and shared parental leave — asking about their relevance to the work–life balance of low‐waged coupled mothers in England. While in principle the policy environment has shifted from assumptions of a male breadwinner to dual earners, in practice severe constraints on mothers' labour market attachment bring women half the lifetime earnings of men. British Household Panel Survey data for coupled low‐waged women in England show them as likely to work short part‐time hours, have low‐waged partners and low household wages while belonging to male breadwinner partnerships in terms of their contribution to household wages and unpaid work; but that few women support this model. Interviews with low‐waged mothers show evidence of limited choices, constrained by social policies which offer limited and piecemeal support for working parenthood. Given the choice, low‐waged mothers and their partners would find policies available elsewhere in Europe attractive. They see a more universal comprehensive system of childcare as enabling women's employment and improving children's quality of life; a shorter working week as enabling mothers and fathers to lead more balanced lives and a father's quota of parental leave fitting with their assumptions about sharing care.     

Effects of gay identity, gender and explicitness of advertising imagery on gay responses to advertising

The present research draws from literature relating to gay identity in psychology and sociology and feminist theory to consider the effect of gay identity and gender on gays' and lesbians' attitudes toward various types of advertising content that are most commonly used to target gay consumers. As such, this study empirically tests whether gay males' and lesbians' responses to gay-oriented advertising content are moderated by individual characteristics: (1) the degree to which they identify as gay, and (2) their gender, and by the explicitness and gender of the gay-oriented advertising imagery.     

Beyond ‘Gender Differences’: A Canadian Study of Women's and Men's Careers in Engineering

This article explores the relationship between gender and career paths for a group of women and men who graduated as engineers during a period of labour market turbulence in western Canada during the 1980s. Using a model adapted from Brown (1982 ), the article uses ‘career path’ as a device to organize data drawn primarily from telephone and face‐to‐face interviews with 317 graduates. Three career paths provide the focus for the study: the ‘organizational’, characterized by stable employment with one employer; the ‘occupational’, characterized by mobility between employers; and the entrepreneurial, characterized by self‐employment. The use of the career path framework moves the study beyond global comparisons (of the dichotomized ‘gender differences’ kind) between ‘the women’ and ‘the men’. As well as allowing for comparison between the paths, it allows more refined and contextualized comparisons within each path. Such comparisons produce patterns of similarity and difference that sometimes transcend gender.