Construction of a Frailty Indicator with Partially Ordered Sets: A Multiple-Outcome Proposal Based on Administrative Healthcare Data

Social Indicators Research - Given the progressive aging of Italian and European populations, the number of cases with chronic diseases is steeply increasing. This calls for new strategies for...     

A spatial analysis of health and pharmaceutical firm survival

The presence of knowledge spillovers and shared human capital is at the heart of the Marhall–Arrow–Romer externalities hypothesis. Most of the earlier empirical contributions on knowledge externalities; however, considered data aggregated at a regional level so that conclusions are based on the arbitrary definition of jurisdictional spatial units: this is the essence of the so-called modifiable areal unit problem. A second limitation of these studies is constituted by the fact that, somewhat surprisingly, while concentrating on the effects of agglomeration on firm creation and growth, the literature has, conversely, largely ignored its effects on firm survival. The present paper aims at contributing to the existing literature by answering to some of the open methodological questions reconciling the literature of Cox proportional hazards model with that on point pattern and thus capturing the true nature of spatial information. We also present some empirical results based on Italian firm demography data collected and managed by the Italian National Institute of Statistics (ISTAT).     

Late-onset hypogonadism: the advantages of treatment with human chorionic gonadotropin rather than testosterone

The traditional pharmacological treatment of patients with late onset hypogonadism (LOH) is represented by different formulations of testosterone (T) or alternatively by the extractive human chorionic gonadotropin (HCG). The hormone replacement treatment (HRT) is associated with the potential increase of hematocrit, serum concentrations of prostate-specific antigen (PSA) and prostate volume. Moreover, the gynecomastia represent a condition frequently associated with HRT. Recent evidences showed the role of leydig cells in the 25-hydroxylation of vitamin D and the elevated frequency of hypovitaminosis D among LOH patients. Finally, another important aspect of LOH is represented by the frequency of secondary infertility due to age or to traditional HRT. This study evaluated 40 LOH patients treated for 6 months with extractive HCG (n?=?10 patients) and three different formulations of T: transdermal (n?=?10 patients), undecaonate (n?=?10 patients) and enantate (n?=?10 patients). Hormonal, anthropometric, metabolic and sperm parameters were evaluated and compared. Moreover, the main safety parameters and the results of the main questionnaires were evaluated. After treatment, HCG group showed serum concentrations of 25-OH-vitamin D significantly higher (p?p?p?p?相似文献   

PARENTS KNOW THEM BETTER: THE EFFECT OF OPTIONAL EARLY ENTRY ON PUPILS' SCHOOLING ATTAINMENT

The effect of optional early school entry on pupils' educational outcomes is investigated using data covering the entire population of Italian primary school students and exploiting exogenous thresholds imposed by norms regulating first enrollment. Results highlight the fact that pupils whose parents can choose when their children start school perform better than those who are bounded by terms imposed by law. These findings suggest that parental choice leads to a better match between pupils' characteristics and the beginning of formal learning. Results show that giving parents the option to anticipate or delay school entry could be a beneficial measure. (JEL I20, H52)     

A new approach to stock price modelling and the efficiency of the Italian stock exchange

In this paper, we propose a new model of asset prices which takes account of the investment strategies of three different kinds of agents: the market-makers, who operate rationally on the basis of the asset fundamentals, the smart buy-and-sell agents, who intervene when the prices reach particular levels and the non-smart buy-and-sell agents, who trade infrequently, mainly following psychological motivations. The different behavior of these groups of agents can determine temporary inefficiences on financial markets and we show that, by considering these inefficiences, it is possible to improve forecasting of asset prices.     

Schengen's Soft Underbelly? Irregular Migration and Human Smuggling across Land and Sea Borders to Italy

La migration illégale à destination de l'Italie ou passant par ce pays est généralement associée dans l'esprit des gens à l'image de centaines, voire de milliers de migrants traversant la Méditerranée entassés dans de vieux rafiots se maintenant tout juste à flot. On considère souvent que les traversées de ce type sont la preuve de l'existence de cartels criminels qui seraient structurés hiérarchiquement, centralisés, extrêmement bien organisés et actifs au niveau mondial. Le seul problème avec de telles idées reçues est qu'elles ne concordent absolument pas avec les faits dont on dispose et n'ont pas grand chose à voir avec la réalité concrète des systèmes de migration illégale. Cette étude passe en revue un certain nombre de dossiers de tribunaux italiens concernant diverses organisations qui opèrent aussi bien au travers des frontières terrestres que maritimes. Elle montre comment de telles organisations opèrent en tenant compte de diverses spécificités locales et contraintes structurelles.     

Lottery- and survey-based risk attitudes linked through a multichoice elicitation task

We analyze the results from three different risk attitude elicitation methods. First, the broadly used test by Holt and Laury (2002), HL, second, the lottery-panel task by Sabater-Grande and Georgantzis (2002), SG, and third, responses to a survey question on self-assessment of general attitude towards risk (Dohmen et al. 2011). The first and the second task are implemented with real monetary incentives, while the third concerns all domains in life in general. Like in previous studies, the correlation of decisions across tasks is low and usually statistically non-significant. However, when we consider only subjects whose behavior across the panels of the SG task is compatible with constant relative risk aversion (CRRA), the correlation between HL and self-assessed risk attitude becomes significant. Furthermore, the correlation between HL and SG also increases for CRRA-compatible subjects, although it remains statistically non-significant.