T Cell Immunity and Aging

The effect of age on the immune system is generally detrimental and results in "immunosenescence," a poorly-defined state inadequately reflected in clinical data and for which few reliable "biomarkers of aging" are available. The multinational consortium "T-Cell Immunity in Ageing," T-CIA, was set up to examine these issues specifically as applied to T lymphocytes. This Perspective discusses some of the outcomes of a recent conference that considered progress toward resolving these questions in humans.     

A survey of substance abuse prevention efforts at Virginia's colleges and universities

The extremes of college student substance use and the negative consequences students face as a result of such use are of great public health concern. Although a multitude of campus-based substance abuse prevention efforts have appeared in literature, a clear picture of the programs and policies currently in use at colleges and universities is not readily available. This research was undertaken to detail both the efforts aimed at general student samples and those targeting at-risk (eg, Greeks, student athletes) and historically underserved (eg, ethnic minorities, students with disabilities) student groups at colleges and universities in the Commonwealth of Virginia. While a variety of efforts were being made, there was a reliance on program orientations with limited scientific support. Four-year institutions used a wider array of outlets for their prevention messages. Targeted programs for at-risk groups were common but were largely unavailable specifically for ethnic minority students and students with disabilities.     

How smart cities transform operations models: a new research agenda for operations management in the digital economy

Abstract

The notion of smart cities is growing in prominence in the digital economy. The integration of urban infrastructures with information and communication technologies enables the development of new operations models. Digitised infrastructures offer opportunities for public and private organisations to design and deliver more customer-centric products or services, particularly for those that require geographical proximity with consumers in the online to offline (O2O) context. A framework is developed and used to analyse three case examples. These cases illustrate the emergence of new operations models and, demonstrate how smart cities are redefining the characteristics of operations models around their scalability, analytical output and connectivity. We also explore the feasibility, vulnerability and acceptability of each new operation. This paper contributes to our understanding of how smart cities can potentially transform operational models, and sets out a research agenda for operations management in smart cities in the digital economy.     

Risky behaviour: a new framework for understanding why young people take risks

Theories of youth risk taking range from the realist to the sociocultural. Much of this theorising, particularly in the field of epidemiology, has been strongly influenced by the Health Belief Framework. More recently, attention has shifted to understanding how young people perceive risk and what makes some of them resilient to risk taking. In this article we develop a framework that brings together diverse theoretical perspectives on youth risk taking. We draw on lessons from across the social science disciplines to inform a conceptual framework incorporating the broad context and internal processes of young people's decisions to take risks. Our Youth Risk Interpretation Framework (Y-RIF) has been developed from insights gained during an ethnographic study conducted in South Africa (Graham, Lauren, 2012. Understanding risk in the everyday identity-work of young people on the East Rand of Johannesburg. Doctoral Thesis. University of Johannesburg, Johannesburg.). We argue that our framework is useful, as it offers new ways of understanding why some young people take risks while others are more cautious. It could be used to inform youth behaviour surveillance research and interventions. However, it will need to be rigorously tested.     

Women's Engagement in Pubic Hair Removal: Motivations and Associated Factors

Objectives: To examine the relationship between women's pubic hair removal (PHR) and genital satisfaction and explore whether attitudes toward, and personal consumption of, pornography are associated with women's engagement in PHR. Methods: Data were collected by online survey from women (N = 152) who were then categorized into groups based on the prevalence and extent of PHR during the previous 4 weeks. Groups were compared on demographic, background, and behavioral variables. Results: Eighty-three percent of respondents reported PHR in the previous 4 weeks and 40% of respondents removed all their pubic hair. Women who were younger, White, and were more satisfied with their genitals were more likely to engage in PHR. Of these, being younger, not having a degree, reporting less positive attitudes toward erotica, and 3 reasons for PHR predicted extensive PHR over limited removal. Conclusions: Findings provide insights into the reasons for, and extent of, PHR among women and factors associated with the practice. The possible influences of partners' preferences for genital hair removal by women and partners' consumption of pornography are important areas for future research.     

Gendered gambling domains and changes in Sweden

Pachinko is an ‘amusement arcade’ type machine that is popular throughout Japan, with an estimated 17.1 million ‘players’ providing an enormous annual revenue of 2.87 trillion yen (US$250 billion). It is simple and easy to play and has all the hallmarks and structural features of gaming machines worldwide. While academic discourses on the addictive potential of gaming machines are well developed, their application to pachinko is very limited. This is, perhaps, due to a number of factors. First, pachinko is portrayed as a game rather than as gambling in Japan, so that addiction issues are ignored or downplayed. Second, most accounts of ‘playing’ pachinko are journalistic rather than academic. Third, academics tend to focus on police corruption and organized crime rather than addiction. Here, we take the approach that pachinko represents ‘gambling by proxy’ and explore its addictive potential. We conclude that unless pachinko is recognized as a form of gambling, present changes in Japanese legislation will be of limited value in tackling addiction.     

Valuing Mortality-Risk Reduction: Using Visual Aids to Improve the Validity of Contingent Valuation

We investigate the validity of contingent valuation (CV) estimates of the value per statistical life (VSL). We test for sensitivity of estimated willingness to pay (WTP) to the magnitude of mortality-risk reduction and for the theoretically predicted proportionality of WTP to risk reduction using alternative visual aids to communicate risk. We find that WTP is sensitive to the magnitude of risk reduction for independent subsamples of respondents presented with each of three alternative visual aids, but not for the subsample presented with no visual aid. Estimated WTP is consistent with proportionality to risk reduction for the subsamples presented with a logarithmic scale or an array of 25,000 dots, but not for the subsample receiving a linear scale. These results suggest that CV can provide valid estimates of WTP for mortality-risk reduction if appropriate methods are used to communicate the risk change to respondents.     

Application of the Precautionary Principle by Senior Policy Officials: Results of a Canadian Survey

Though use of the controversial precautionary principle in risk management has increasingly been recommended as a guide for the construction of public policy in Canada and elsewhere, there are few data available characterizing its use in risk management by senior public policymakers. Using established survey methodology we sought to investigate the perceptions and terms of application of the precautionary principle in this important subset of individuals. A total of 240 surveys were sent out to seven departments or agencies in the Canadian government. The overall survey response rate was 26.6%, and our findings need to be interpreted in the context of possible responder bias. Of respondents, the overwhelming majority perceived the precautionary principle and the management of risk as complementary, and endorsed a role for the precautionary principle as a general guideline for all risk management decisions. However, 25% of respondents responded that the lack of clarity of the definition of the principle was a limitation to its effective use. The majority of respondents viewed their own level of understanding of the precautionary principle as moderate. Risk managers appeared to favor an interpretation of the precautionary principle that was based on the seriousness and irreversibility of the threat of damage, and did not endorse as strongly the need for cost effectiveness in the measures taken as a precaution against such threats. In contrast with its perceived role as a general guideline, the application of the precautionary principle by respondents was highly variable, with >60% of respondents reporting using the precautionary principle in one-quarter or less of all risk management decisions. Several factors influenced whether the precautionary principle was applied with the perceived seriousness of the threat being considered the most influential factor. The overwhelming majority of risk managers felt that "preponderance of evidence" was the level of evidence required for precautionary action to be instituted against a serious negative event. Overall, the majority of respondents viewed the precautionary principle as having a significant and positive impact on risk management decisions. Importantly, respondents endorsed a net result of more good than harm to society when the precautionary principle was applied to the management of risk.