有限度的乐观:澳大利亚与中国的崛起

近年来,中国的经济增长状况以及对其未来的展望对于澳大利亚来说是非常有利的.如果像一些人预计的那样,中国在未来25年中保持强劲的增长,那么它将改变澳大利亚的经济前景,取代日本成为国家繁荣的主要推动力.中国也将改变亚洲地区:中国增长的引力作用已经使东亚经济日益整合为地区经济,而这也为更紧密的政治一体化提供了基础.     

至关重要的创造力:国家的视角

许多人从学生、教师和教育机构的角度来看待创造力的重要性,我的兴趣却在于创造力与国家繁荣之间的联系.为了在今后数十年内保持我们的生活水平,我们需要一些新的职业,而产生这些新职业离不开创造力和创新.由于创新过程本身涉及并需要新的技能,我们的大专院校必须努力在学生、教师和更广泛的社会中促进创造力的形成.     

Maximum Likelihood Estimations and EM Algorithms with Length-biased Data

Length-biased sampling has been well recognized in economics, industrial reliability, etiology applications, epidemiological, genetic and cancer screening studies. Length-biased right-censored data have a unique data structure different from traditional survival data. The nonparametric and semiparametric estimations and inference methods for traditional survival data are not directly applicable for length-biased right-censored data. We propose new expectation-maximization algorithms for estimations based on full likelihoods involving infinite dimensional parameters under three settings for length-biased data: estimating nonparametric distribution function, estimating nonparametric hazard function under an increasing failure rate constraint, and jointly estimating baseline hazards function and the covariate coefficients under the Cox proportional hazards model. Extensive empirical simulation studies show that the maximum likelihood estimators perform well with moderate sample sizes and lead to more efficient estimators compared to the estimating equation approaches. The proposed estimates are also more robust to various right-censoring mechanisms. We prove the strong consistency properties of the estimators, and establish the asymptotic normality of the semi-parametric maximum likelihood estimators under the Cox model using modern empirical processes theory. We apply the proposed methods to a prevalent cohort medical study. Supplemental materials are available online.     

一个新的稳健ARCH检验和YJ-GARCH模型

 众所周知,Engle (1982) 的ARCH检验对于条件均值模型误设并不稳健,特别地,当条件均值是非线性过程而我们仅对之建立线性模型时,它过度地拒绝真实的原假设,导致出现严重的水平扭曲 (size distortion)。因此,本文在文献当中首次利用Yeo-Johnson变换方法来转换均值模型的因变量以排除ARCH 过程中均值部分的非线性,进而提出一个新的稳健ARCH检验以及一个新的GARCH模型——Yeo-Johnson (YJ) GARCH模型。蒙特卡罗模拟结果表明,稳健的ARCH检验在水平 (size) 和势 (power) 方面的表现要显著优于Engle (1982) 的ARCH检验。对上证综指收益率的实证研究结果表明,YJ-GARCH模型的拟合效果要显著优于线性GARCH模型。     

Semi-parametric hybrid empirical likelihood inference for two-sample comparison with censored data

Two-sample comparison problems are often encountered in practical projects and have widely been studied in literature. Owing to practical demands, the research for this topic under special settings such as a semiparametric framework have also attracted great attentions. Zhou and Liang (Biometrika 92:271–282, 2005) proposed an empirical likelihood-based semi-parametric inference for the comparison of treatment effects in a two-sample problem with censored data. However, their approach is actually a pseudo-empirical likelihood and the method may not be fully efficient. In this study, we develop a new empirical likelihood-based inference under more general framework by using the hazard formulation of censored data for two sample semi-parametric hybrid models. We demonstrate that our empirical likelihood statistic converges to a standard chi-squared distribution under the null hypothesis. We further illustrate the use of the proposed test by testing the ROC curve with censored data, among others. Numerical performance of the proposed method is also examined.     

Combined survival analysis of cardiac patients by a Cox PH model and a Markov chain

The control and treatment of dyslipidemia is a major public health challenge, particularly for patients with coronary heart diseases. In this paper we propose a framework for survival analysis of patients who had a major cardiac event, focusing on assessment of the effect of changing LDL-cholesterol level and statins consumption on survival. This framework includes a Cox PH model and a Markov chain, and combines their results into reinforced conclusions regarding the factors that affect survival time. We prospectively studied 2,277 cardiac patients, and the results show high congruence between the Markov model and the PH model; both evidence that diabetes, history of stroke, peripheral vascular disease and smoking significantly increase hazard rate and reduce survival time. On the other hand, statin consumption is correlated with a lower hazard rate and longer survival time in both models. The role of such a framework in understanding the therapeutic behavior of patients and implementing effective secondary and primary prevention of heart diseases is discussed here.     

Statistical approaches for conducting network meta-analysis in drug development

We introduce health technology assessment and evidence synthesis briefly, and then concentrate on the statistical approaches used for conducting network meta-analysis (NMA) in the development and approval of new health technologies. NMA is an extension of standard meta-analysis where indirect as well as direct information is combined and can be seen as similar to the analysis of incomplete-block designs. We illustrate it with an example involving three treatments, using fixed-effects and random-effects models, and using frequentist and Bayesian approaches. As most statisticians in the pharmaceutical industry are familiar with SAS? software for analyzing clinical trials, we provide example code for each of the methods we illustrate. One issue that has been overlooked in the literature is the choice of constraints applied to random effects, and we show how this affects the estimates and standard errors and propose a symmetric set of constraints that is equivalent to most current practice. Finally, we discuss the role of statisticians in planning and carrying out NMAs and the strategy for dealing with important issues such as heterogeneity.     

Designing a non-inferiority study in kidney transplantation: a case study

In organ transplantation, placebo-controlled clinical trials are not possible for ethical reasons, and hence non-inferiority trials are used to evaluate new drugs. Patients with a transplanted kidney typically receive three to four immunosuppressant drugs to prevent organ rejection. In the described case of a non-inferiority trial for one of these immunosuppressants, the dose is changed, and another is replaced by an investigational drug. This test regimen is compared with the active control regimen. Justification for the non-inferiority margin is challenging as the putative placebo has never been studied in a clinical trial. We propose the use of a random-effect meta-regression, where each immunosuppressant component of the regimen enters as a covariate. This allows us to make inference on the difference between the putative placebo and the active control. From this, various methods can then be used to derive the non-inferiority margin. A hybrid of the 95/95 and synthesis approach is suggested. Data from 51 trials with a total of 17,002 patients were used in the meta-regression. Our approach was motivated by a recent large confirmatory trial in kidney transplantation. The results and the methodological documents of this evaluation were submitted to the Food and Drug Administration. The Food and Drug Administration accepted our proposed non-inferiority margin and our rationale.     

社会主义劳动的基本矛盾

社会主义劳动的矛盾问题是一个十分迫切而经济学家对它又研究得很不够的问题.长期以来,大多数经济学家把社会主义劳动的矛盾同旧社会的"遗毒"或者同社会主义应该加以克服的某些缺点联在一起.当然,不能否认这类矛盾的存在,也不能否认有必要对它们加以研究.但是,这类矛盾并不是社会主义劳动发展的源泉.另一些经济学家认为