Recommendations on the statistical analysis of the Comet assay

In 2010, the Statisticians in the Pharmaceutical Industry (PSI) Toxicology Special Interest Group met to discuss the design and analysis of the Comet assay. The Comet assay is one potential component of the package of safety studies required by regulatory bodies. As these studies usually involve a three-way nested experimental design and as the distribution of the measured response is usually either lognormal or lognormal plus a point mass at zero, the analysis is not straightforward. This has led to many different types of analysis being proposed in the literature, with several different methods applied within the pharmaceutical industry itself. This article summarises the PSI Toxicology Group's discussions and recommendations around these issues.     

On optimal allocation of redundant components for series and parallel systems of two dependent components

In this paper we consider the problem of optimal allocation of a redundant component in the case of series and parallel systems of two components when all the components are dependent. Whereas this problem has been extensively treated for the case of independent components, the case of dependent components has not received too much attention. In this paper we show that for this problem the main tools are the joint stochastic orders introduced by Shanthikumar and Yao (1991).     

Relationships between Borda voting and Zermelo ranking

There are many situations wherein a group of individuals (e.g., voters, experts, sports writers) must produce an ordered list of ‘best’ alternatives selected from a given group of alternatives (e.g., candidates, proposals, sports teams). Two long established mechanisms that have been used for this task are ‘Zermelo’s Ranking Method’ (1929) and ‘Borda’s Voting Scheme’ (1781). The main purpose of this paper is to point out that they are, under certain common circumstances, identical. We then show that Zermelo’s Method can be used in situations that Borda’s Method is not designed to handle.     

Relationships in a new country: A qualitative study of the social connections of refugee youth resettled in South Australia

Australia's approach to immigration, as internationally, is largely concerned with state sovereignty, border protection and restrictionism towards asylum seekers. However, with just under a million refugees currently residing in Australia, and with 13,750 more added to this number each year, there is also an interest in ensuring that those who are granted humanitarian protection are socially integrated. This article reports on a qualitative investigation of the integration experiences of 85 refugee adolescents aged 13–17 years resettled in Adelaide, South Australia. It explores, in particular, the role of social connectedness in the integration process. Relationships with family, ethnic group and host country are believed to affect multiple and interrelated integration outcomes including language acquisition, cultural knowledge, belonging, identity, civic engagement, social and economic participation, and access to public services. This research found that young people must negotiate the integration process with variable, and in many cases limited, support from the network of social connections surrounding them. We suggest that policy and programmes which strengthen the relationships young people have with others have the potential to enhance integration outcomes.     

The impacts of painful noise in the apprehension of sound references on context of a big band

This study aims to describe the painfulness applied to situations of teaching-learning of a Big Band in a School of Music of a Brazilian Federal University. Moreover, the concept of what painful noise is will be developed, applied to this context. After Ergonomic Work Analysis [2], the following variables were selected to characterize the painful noise: volume, height, frequency, sound confluence and reverberation. To relate the influence of painful noise on modes operatives, were explained the operative strategies used by teacher and students during the performance in group of this Big Band.     

The challenges of interdisciplinary education and its application on teaching ergonomics

The education in Brazil is still strongly based on traditional teaching methods that reinforce a passive attitude of the student. Despite the educational guidelines indicate the need for more liberating and interdisciplinary methodologies, there are few actions for change. Within this context, interdisciplinary appears as an important tool to help the creation of a new thinking in education, proposing the connection between the parts of an area of knowledge. In this way leading the student to develop a more critical and reflective thinking about the reality of the community where he lives. Being understood ergonomics as a scientific discipline that looks for the interactions among humans and other elements of a system in order to optimize human well-being and overall system performance, interdisciplinary has become essential in this process. The aim of this study was to discuss the educational foundations of interdisciplinarity and their applicability in the teaching of ergonomics in the context of Brazil.     

Accessibility for all: going from theory to practice

The present work demonstrates, through a case study, the importance of theoretical knowledge in practical application of spatial accessibility in order to guarantee equal conditions for all people in the movement and use of space. Initially there was a literature review on the accessibility of space and how design in a accessible way. Next, we show one makeover proposal in one public school that wants to provide access to people with disabilities. This makeover was done and so we could evaluate the buildings changes through the method of accompanied walk with two people. Finally we present the main results and discussions.     

HCBS Spending and Nursing Home Admissions for 1915(c) Waiver Enrollees

Medicaid waiver programs for home- and community-based services (HCBS) have grown rapidly and serve a population at high risk for nursing home (NH) admission. This study utilized the Medicaid Analytic Extract Personal Summary File and the NH Minimum Data Set and tested whether higher levels of per-beneficiary HCBS spending were associated with (1) lower risk of long-term (90+ days) NH admission and (2) higher functional/cognitive impairment at admission for new enrollees in 1915(c) aged or aged and disabled waiver programs. Waiver enrollees in states and counties with higher HCBS spending were found to have lower risk of long-term NH admission and greater functional impairment at NH admission compared to waiver enrollees in states and counties with lower spending. This indicates that higher per-enrollee HCBS spending may enable waiver enrollees to remain in the community until their functional impairment becomes more severe.     

Workplace aesthetics: Impact of environments upon employee health?

Associations between self-reported need for aesthetic improvements in the workplace and the need for ergonomic improvement and health factors were investigated to determine the possible impact of aesthetic needs on job performance. The need for aesthetic improvements were compared with the need for ergonomic improvements. All employees at a Swedish broadcasting company were invited to participate in this cross sectional study. Of those who fulfilled the inclusion criteria the participation rate was 74% (1961/2641). Demographic data was obtained from company files and pre-validated questionnaire was used for data collections from the participants. additional questions on needs for improvement were developed, tested for repeatability, and demonstrated to be within acceptable limits. Differences between 'high rank' and 'low rank' aesthetic needs and ergonomic needs were correlated to set ups of demographic, work environmental and organisational and health variables.The perceived needs for aesthetic and ergonomic improvements showed significantly different distributions (p<0.001). Aesthetic needs were more frequently reported than ergonomic needs. There was no significant gender related difference in response distribution of aesthetic or ergonomic needs, whereas differences between occupational groups were shown (0.006 and 0.003). 'High rank' needs for aesthetic improvement were associated to psychologically demanding work, negative work stress, sleep disturbances, problems at work, musculoskeletal pain and lower age. Gender and physical training did not differ between 'high and low rank' responders regarding neither aesthetic nor ergonomic needs. Sick leave was stronger related to ergonomics. The independently tested associations with aesthetic needs were similar to, but fewer than those for ergonomic needs with regard to the variable set ups. Sixteen studied factors out of 24, showed significant difference between 'high and low rank' aesthetic needs, and 21/24 of ergonomic needs, independently tested. The study results show a relation between work place aesthetics and health and well-being. Future work health promotion and prevention may benefit from the inclusion of an assessment of workplace aesthetics.