A goodness-of-fit test for multivariate multiparameter copulas based on multiplier central limit theorems

Recent large scale simulations indicate that a powerful goodness-of-fit test for copulas can be obtained from the process comparing the empirical copula with a parametric estimate of the copula derived under the null hypothesis. A first way to compute approximate p-values for statistics derived from this process consists of using the parametric bootstrap procedure recently thoroughly revisited by Genest and Rémillard. Because it heavily relies on random number generation and estimation, the resulting goodness-of-fit test has a very high computational cost that can be regarded as an obstacle to its application as the sample size increases. An alternative approach proposed by the authors consists of using a multiplier procedure. The study of the finite-sample performance of the multiplier version of the goodness-of-fit test for bivariate one-parameter copulas showed that it provides a valid alternative to the parametric bootstrap-based test while being orders of magnitude faster. The aim of this work is to extend the multiplier approach to multivariate multiparameter copulas and study the finite-sample performance of the resulting test. Particular emphasis is put on elliptical copulas such as the normal and the t as these are flexible models in a multivariate setting. The implementation of the procedure for the latter copulas proves challenging and requires the extension of the Plackett formula for the t distribution to arbitrary dimension. Extensive Monte Carlo experiments, which could be carried out only because of the good computational properties of the multiplier approach, confirm in the multivariate multiparameter context the satisfactory behavior of the goodness-of-fit test.     

Sample size determination and treatment screening in two‐stage phase II clinical trials via ROC curve

In pharmaceutical‐related research, we usually use clinical trials methods to identify valuable treatments and compare their efficacy with that of a standard control therapy. Although clinical trials are essential for ensuring the efficacy and postmarketing safety of a drug, conducting clinical trials is usually costly and time‐consuming. Moreover, to allocate patients to the little therapeutic effect treatments is inappropriate due to the ethical and cost imperative. Hence, there are several 2‐stage designs in the literature where, for reducing cost and shortening duration of trials, they use the conditional power obtained from interim analysis results to appraise whether we should continue the lower efficacious treatments in the next stage. However, there is a lack of discussion about the influential impacts on the conditional power of a trial at the design stage in the literature. In this article, we calculate the optimal conditional power via the receiver operating characteristic curve method to assess the impacts on the quality of a 2‐stage design with multiple treatments and propose an optimal design using the minimum expected sample size for choosing the best or promising treatment(s) among several treatments under an optimal conditional power constraint. In this paper, we provide tables of the 2‐stage design subject to optimal conditional power for various combinations of design parameters and use an example to illustrate our methods.     

Quality of life indicators and health: Current status and emerging conceptions

Quality of life is an increasingly common theme in the health status and health promotion literatures. Six approaches that consider quality of life and health are reviewed. These are (a) health-related quality of life; (b) quality of life as social diagnosis in health promotion; (c) quality of life among persons with developmental disabilities; (d) quality of life as social indicators; (e) the Centre for Health Promotion (University of Toronto) model, and (f) Lindstrom's quality of life model. Each approach is considered as to its emphasis on objective or subjective indicators, individual or system-level measurement, value-laden or value-neutral assumptions, and potential relationship to social policy and social change goals. The links among the social indicators, quality of life, and health promotions areas are examined.