Dementia with cerebrovascular disease

In this case study, we review the symptoms, cognitive testing, brain imaging, and brain pathology of a woman with dementia, for whom the neuropathological findings suggest a prominent contribution of cerebrovascular disease. Vascular dementia is the term commonly used for persons with dementia resulting from strokes, either clinically evident or subclinical "silent" events. "Mixed dementia" is the term used when there is an admixture of pathological findings related to Alzheimer's disease (AD) and cerebrovascular disease, as in this situation. In some cases of mixed dementia, the pathological involvement of AD may be the principal contributory cause of the cognitive symptoms, and in others, the vascular changes may give the greater contribution.     

Implementation fidelity in a teacher-led alcohol use prevention curriculum

There is now ample evidence that teachers tend to make substantial modifications to both the prescribed content and methods of the curricula they administer, and that such modifications are likely to attenuate curricula effects. We examine the fidelity with which teachers implement "Protecting You, Protecting Me," an underage alcohol use prevention curriculum. Findings suggest that while teachers attempted to implement most sections of a lesson, the lessons taught were consistently--and often extensively--adapted. We conclude that since teachers are likely to continue to modify lessons, curriculum developers and trainers should enhance their understanding of how prevention curricula are taught under real world conditions, help teachers to reinforce key curriculum concepts, and consider modifying those curricular sections that teachers are adapting with greatest frequency.     

Human embryonic stem cell research: an argument for national research review

The US National Academy of Sciences (NAS) recently published voluntary guidelines for human embryonic stem (hES) cell research. The NAS guidelines propose two levels of oversight. AT the local level, research institutions are to create Embryonic Stem Cell Research Oversight (ESCRO) committees with a mandate to assess the scientific merit and ethical acceptability of hES cell research. At the national level, a new committee is to be created, not to review specific research proposals, but rather to periodically assess, and as needed revise, the NAS guidelines. In this article, we critically assess this proposal. In particular, we review the benefits and limitations of local research review. On this basis, we argue that local review is insufficient for hES cell research and that while there are obvious pragmatic and political reasons for the NAS to favor local research review, there are more compelling reasons for the NAS to have recommended national review of hES cell research proposals.     

基于关系互动的品牌资产概念、维度与量表开发

基于消费者－品牌关系视角的品牌资产研究代表了品牌资产研究的新阶段,但目前还缺乏具有良好理论基础的测量模型和量表。以社会心理学人际关系发展理论为基础,界定基于关系互动的品牌资产概念和维度,建立测量模型;在系统分析已有研究的基础上,结合焦点小组访谈,开展大规模问卷调研,开发基于关系互动的品牌资产测量量表,利用信度分析、探索性因子分析和验证性因子分析方法对量表信度和效度进行检验。研究结果表明,基于关系互动的品牌资产量表具有良好的信度、内容效度、收敛效度和判别效度,该量表包含品牌个性、品牌互惠、品牌礼遇、关系地位和关系能量5个维度。研究结果为后续的实证研究提供了测量基础,同时也为品牌管理者提供了品牌资产评估工具。     

Alternative sensitivity analyses for regression estimates of treatment effects to unobserved confounding in binary and survival data

Statistical Methods & Applications - Estimates of treatment effects in non-experimental studies are subject to bias owing to unobserved confounding. It is desirable to assess the sensitivity of...     

From Non-Believer to Believer: What Leads People to Change Their Climate Views

Studies have highlighted the political, economic, and psychological factors in the debate over anthropogenic climate change—a hegemony approach—but have rarely focused on the stories and possibilities of people's transitions from climate change non-believer to climate change believer. Based on publicly accessible narratives, this study examines the stories of those who have switched from non-believer to believer—a narrative approach—and the dilemmas involved in those switches. Our investigation illuminates that a transition to climate change believer is a cultural and moral matter based on changing social relations of knowledge and what people regard as ignorable. We find that narratives of transition commonly describe interrelated shifts in three social relational factors: the narrator's notions of self, material reality, and justice. We term this contextualized transformative experience a relational rupture. Our narrative approach thus contextualizes climate change denialism within a person's web of social relations, not the hegemony of climate change communication alone. Moreover, we suggest that, since public debate and polarization on scientific topics such as climate change, vaccination, and COVID-19 are socially situated, they may potentially be socially bridged.