Is the Gene-Environment Interaction Paradigm Relevant to Genome-Wide Studies? The Case of Education and Body Mass Index

This study uses data from the Framingham Heart Study to examine the relevance of the gene-environment interaction paradigm for genome-wide association studies (GWAS). We use completed college education as our environmental measure and estimate the interactive effect of genotype and education on body mass index (BMI) using 260,402 single-nucleotide polymorphisms (SNPs). Our results highlight the sensitivity of parameter estimates obtained from GWAS models and the difficulty of framing genome-wide results using the existing gene-environment interaction typology. We argue that SNP-environment interactions across the human genome are not likely to provide consistent evidence regarding genetic influences on health that differ by environment. Nevertheless, genome-wide data contain rich information about individual respondents, and we demonstrate the utility of this type of data. We highlight the fact that GWAS is just one use of genome-wide data, and we encourage demographers to develop methods that incorporate this vast amount of information from respondents into their analyses.     

SOME DEMOGRAPHIC CORRELATES OF HIV/AIDS-RELATED DISCRIMINATION

In late 1991, a survey was made of HIV/AIDS-related discrimination in the Australian community. Structured telephone interviews were conducted with a random sample of 2,053 respondents. Twenty-one questions provided an index of expressed discrimination. Social contact with HIV-positive people was a significant predictor of low levels of discrimination. Other important predictors of (lower) levels of discrimination were: social contact with gay men, education, sex, age, sexual identity, and sexual experience. Social contact with gay men was the single best predictor of positive attitudes towards people with HIV/AIDS.     

The effect of residence in enclaves on civic concern: An initial exploration

Will those residing in urban enclaves—enclosed socially homogenous residential communities protected by private security—have a lower level of civic concern as compared to those who do not reside in such enclaves? Reich's (1991) work suggests that this is to be expected. To conduct an empirical test, two random samples were drawn from two areas of New York City, one a residential enclave—Battery Park City—the other a non-enclave—Chelsea. The analysis establishes that those who do not live in the enclave have a statistically significant higher level of civic concern. Sample respondent years of education, age, income, gender, and career (arts/business) differences were employed as control variables; after having introduced each control variable independently, the main research hypothesis was sustained.     

Robust and nonparametric subset selection procedures

Subset selection procedures based on ranks have been investigated by a number of authors previously. Their methods are based on ranking the samples from all the populations jointly. However, as was pointed out by Rizvi and Woodworth (1970), the procedures they proposed cannot control the probability of a correct selection over the entire parameter space. In this paper, we propose a subset selection procedure based on pairwise rather than joint ranking of the samples. It is shown that this procedure controls the probability of a correct selection over the entire parameter space. It is also shown that the Pitman efficiency of this nonparametric procedure relative to the multivariate t procedure of Gupta (1956, 1965) is the same as the Pitman efficiency of the Mann-Whitney-Wilcoxon test relative to the t-test.     

Human embryonic stem cell research: an argument for national research review

The US National Academy of Sciences (NAS) recently published voluntary guidelines for human embryonic stem (hES) cell research. The NAS guidelines propose two levels of oversight. AT the local level, research institutions are to create Embryonic Stem Cell Research Oversight (ESCRO) committees with a mandate to assess the scientific merit and ethical acceptability of hES cell research. At the national level, a new committee is to be created, not to review specific research proposals, but rather to periodically assess, and as needed revise, the NAS guidelines. In this article, we critically assess this proposal. In particular, we review the benefits and limitations of local research review. On this basis, we argue that local review is insufficient for hES cell research and that while there are obvious pragmatic and political reasons for the NAS to favor local research review, there are more compelling reasons for the NAS to have recommended national review of hES cell research proposals.     

基于关系互动的品牌资产概念、维度与量表开发

基于消费者－品牌关系视角的品牌资产研究代表了品牌资产研究的新阶段,但目前还缺乏具有良好理论基础的测量模型和量表。以社会心理学人际关系发展理论为基础,界定基于关系互动的品牌资产概念和维度,建立测量模型;在系统分析已有研究的基础上,结合焦点小组访谈,开展大规模问卷调研,开发基于关系互动的品牌资产测量量表,利用信度分析、探索性因子分析和验证性因子分析方法对量表信度和效度进行检验。研究结果表明,基于关系互动的品牌资产量表具有良好的信度、内容效度、收敛效度和判别效度,该量表包含品牌个性、品牌互惠、品牌礼遇、关系地位和关系能量5个维度。研究结果为后续的实证研究提供了测量基础,同时也为品牌管理者提供了品牌资产评估工具。     

Alternative sensitivity analyses for regression estimates of treatment effects to unobserved confounding in binary and survival data

Statistical Methods & Applications - Estimates of treatment effects in non-experimental studies are subject to bias owing to unobserved confounding. It is desirable to assess the sensitivity of...