Ticking fast or ticking slow, through Shc must you go?

Circumstantial evidence places the p66 isoform of the adapter protein Shc in a position to mediate the accelerated aging phenotype displayed by mice expressing shortened forms of the tumor suppressor protein p53. We present a model in which p66(shc) may be responsible for integrating signals from the p53 pathway with signals from the insulin-like growth factor-1/Daf pathway in mammals. A full understanding of how interactions between p53 and p66(shc) affect longevity will require the production of animals with mutations in the genes encoding both proteins.     

Evaluation of an upper extremity student-role functioning scale using item response theory

Millions of workers suffer from upper extremity (musculoskeletal) disorders. Many of these workers are predisposed to upper extremity musculoskeletal disorders because of early exposure to ergonomic risks as students. Computer usage for four or more hours remains the greatest risk for upper extremity musculoskeletal disorders for workers and students alike. Developing preventative methods to reduce student exposure, and thus protect future workers from upper extremity musculoskeletal disorders later in life, requires an appropriate measure for upper extremity musculoskeletal disorder prevalence and related limitations for student functioning. Item response theory analysis was used to evaluate and further develop a upper extremity functioning scale for the student role.     

Stalking and other forms of intrusive contact after the dissolution of adolescent dating or romantic relationships

Social science research has recently begun to focus on stalking and other forms of intrusive contact occurring among adolescents and young adults. This article presents results from a survey of 681 undergraduates about their experiences with stalking or other forms of intrusive contact occurring after the end of a dating or romantic relationship. Twenty percent of the respondents had been the target of intrusive contact, 8% had initiated intrusive contact, and 1% had been the target of intrusive contact after one relationship and had initiated intrusive contact after another. More females than males were the target of intrusive contact; however, there were no sex differences associated with initiating intrusive contact. About 20% of the respondents had feared for their safety during the intrusive contact. Thirty-one percent of the respondents described the intrusive contact as having a decidedly negative influence on either their subsequent dating relationships or their lives in general.     

Prevalence Rates of Youth Gambling Problems: Are the Current Rates Inflated?

While there is a general consensus in the literature that it is common for youth to gamble, considerable variability in the reported prevalence rates of youth problem gambling has been found. More recently, issues concerning the possible overestimation of these rates have been raised. Arguments underlying the proposition that problem gambling rates for youth are inflated are examined. It is acknowledged that more rigorous research is required, including the need for the development and refinement of current adolescent instruments and screening tools, agreement upon a gold standard criterion for adolescent problem gambling, and clarity of nomenclature issues. The advancement of scientific knowledge concerning the underlying risk factors associated with the onset and course of youth gambling involvement and the role of effective adolescent prevention and treatment programs will require these fundamental research questions to be addressed.     

Deconstructing the pipeline: using efficacy, effectiveness, and cost-benefit data to reduce minority youth incarceration

Investing in effective prevention and early intervention programs will reduce human costs of victimization and also save tax dollars in the short and long terms.     

Does the road to muscle rejuvenation go through Notch?

The capacity of skeletal muscles to repair and regenerate declines during aging in humans, and this decline may lead to muscle loss and frailty. Conboy et al. show that injured muscles of aging mice are defective in Notch signaling, because up-regulation of the Notch ligand, Delta-1, is impaired. Delta-1 promotes proliferation of the satellite cells that repair damaged muscles, and Conboy et al. show that experimental activation of Notch signaling is sufficient to reverse the age-related decline in muscle regenerative capacity. Extension of these important findings to humans could lead to the development of new therapeutic approaches to maintain muscle function during aging.     

Technology transfer — and the U.S. space program

Using ten years of data in the structured technology transfer program of the United States National Aeronautics and Space Administration as a base, a rough model of the nature and significance of research and development and its movement as technology is presented. Painted in economic hues is the economic return of technology of 7·23 to 1 over an 18 year period, in technical terms—the nature of integrated circuit technology transfer and the public significance of technology transfer to the problems of rechargeable Cardiac Pacemakers. The distinction between natural technology diffusion and intended technology transfer is made to outline the movement of technology through the U.S. economy.     

Branded: The Economic Geographies of Streets Named in Honor of Reverend Dr. Martin Luther King,Jr.*

Objectives. We investigate the economic geographies of streets named for Reverend Dr. Martin Luther King, Jr. (MLK Streets), which are an increasingly common means by which various community members across the United States are attempting to commemorate the slain civil rights leader. It is our intent to characterize these negatively “branded” spaces in order to challenge some of the common perceptions about them and inform current and future MLK Street naming debates. Methods. We statistically analyze nonresidential establishments located on streets named for King in terms of scale (as measured by annual sales and employment) and industrial classification. To our knowledge, this is the first such analysis conducted at the national level. Results. Establishments located on MLK Streets do not systematically exhibit economic marginality. Establishments located on these streets do systematically exhibit unique local functions and industrial composition. Conclusion. In the absence of empirically‐driven research, the negative stereotypes that surround MLK Streets have gone unchallenged and are proliferating. The research reported here calls into question a number of these stereotypes and should inform the public, city councils, and other local policymakers, who are increasingly being faced with contentious MLK Street naming debates.