Bayesian Risk Ratio Analysis

The classical confidence interval approach has failed to find exact intervals, or even a consensus on the best approximate intervals, for the ratio of two binomial probabilities, the so-called risk ratio. The problem is reexamined from a Bayesian viewpoint, and a simple graphical presentation of the risk ratio assessment is given in such a way that sensitivity to the selected prior distribution can be readily examined.     

Statistical Computing: History and Trends

The evolution of computers is currently in a period of rapid change, stimulated by radically cheaper and smaller devices for processing and memory. These changes are certain to provide major opportunities and challenges for the use of computers in statistics. This article looks at history and current trends, in both general computing and statistical computing, with the goal of identifying key features and requirements for the near future. A discussion of the S language developed at Bell Laboratories illustrates some program design principles that can make future work on statistical programs more effective and more valuable.     

Bayesian model comparison for compartmental models with applications in positron emission tomography

We develop strategies for Bayesian modelling as well as model comparison, averaging and selection for compartmental models with particular emphasis on those that occur in the analysis of positron emission tomography (PET) data. Both modelling and computational issues are considered. Biophysically inspired informative priors are developed for the problem at hand, and by comparison with default vague priors it is shown that the proposed modelling is not overly sensitive to prior specification. It is also shown that an additive normal error structure does not describe measured PET data well, despite being very widely used, and that within a simple Bayesian framework simultaneous parameter estimation and model comparison can be performed with a more general noise model. The proposed approach is compared with standard techniques using both simulated and real data. In addition to good, robust estimation performance, the proposed technique provides, automatically, a characterisation of the uncertainty in the resulting estimates which can be considerable in applications such as PET.