Admissible two-stage designs for phase II cancer clinical trials that incorporate the expected sample size under the alternative hypothesis

two‐stage studies may be chosen optimally by minimising a single characteristic like the maximum sample size. However, given that an investigator will initially select a null treatment e?ect and the clinically relevant di?erence, it is better to choose a design that also considers the expected sample size for each of these values. The maximum sample size and the two expected sample sizes are here combined to produce an expected loss function to ?nd designs that are admissible. Given the prior odds of success and the importance of the total sample size, minimising the expected loss gives the optimal design for this situation. A novel triangular graph to represent the admissible designs helps guide the decision‐making process. The H ₀‐optimal, H ₁‐optimal, H ₀‐minimax and H ₁‐minimax designs are all particular cases of admissible designs. The commonly used H ₀‐optimal design is rarely good when allowing stopping for e?cacy. Additionally, the δ‐minimax design, which minimises the maximum expected sample size, is sometimes admissible under the loss function. However, the results can be varied and each situation will require the evaluation of all the admissible designs. Software to do this is provided. Copyright © 2012 John Wiley & Sons, Ltd.     

A COMPARISON OF ANALYSIS METHODS FOR LATE‐STAGE VARIETY EVALUATION TRIALS

The statistical analysis of late‐stage variety evaluation trials using a mixed model is described, with one‐ or two‐stage approaches to the analysis. Two sets of trials, from Australia and the UK, were used to provide realistic scenarios for a simulation study to evaluate the different methods of analysis. This study showed that a one‐stage approach gave the most accurate predictions of variety performance overall or within each environment, across a range of models, as measured by mean squared error of prediction or realized genetic gain. A weighted two‐stage approach performed adequately for variety predictions both overall and within environments, but a two‐stage unweighted approach performed poorly in both cases. A generalized heritability measure was developed to compare methods.     

Comparing the effectiveness of behavioral interventions in adults with co-occurring tobacco and substance use disorders: a systematic review of literature

ABSTRACT

This systematic literature review compares the e?ectiveness of various behavioral interventions delivered to persons with co-occurring tobacco and substance use disorders. It examines ?ndings of six randomized trials and three secondary analyses from randomized trials. Based on the ?ndings of this literature review, support is given to the following: (1) The consequences of tobacco use and smoking are deadly, costly, and can have an inhibitory e?ect on the progress of people in substance abuse treatment, (2) tobacco cessation options are a preventive intervention that can be easily incorporated into a treatment facility’s standard of practice and should be made available within the context of all substance abuse treatment facilities, and (3) concurrently treating tobacco use disorder and substance use disorder(s) is an e?ort that will help meet the social work profession’s Grand Challenge to ‘Close the Health Gap.’     

Educator Sexual Misconduct and Texas Educator Discipline Database Construction

ABSTRACT

The purpose of this research is to describe Texas educator sexual misconduct (ESM) by examining 8 years of sanctions issued to educators (N = 1415) for either sexual misconduct or inappropriate relationships with students or minors. We first examine Texas ESM from the perspective of quality database construction and then describe the demographic characteristics of educators sanctioned for ESM between 2008 and 2016. Differences in the demographic characteristics of educators sanctioned for ESM vary according to the definition of ESM employed by the state education agency. Younger and early career educators are more likely to engage in inappropriate relationships with students or minors, whereas older and later-career teachers are more likely to engage in sexual misconduct as that term is defined by the state education agency. Over one-third of educators sanctioned for ESM were either new to the profession or new to their school district when sanctioned. Recommendations are offered for database construction, policy, and practice.     

Stressful and positive experiences of women who served in Vietnam

Experiences of women who served during the Vietnam War have been described in interviews/anecdotal reports but rarely in empirical literature. Potential positive (versus negative) aspects of service or its impact on well-being are seldom considered. We describe stressful and positive experiences reported by approximately 1,300 female military personnel, Red Cross workers, and others deployed to Vietnam. Prominent stressful (e.g., negative living/working conditions) and positive (e.g., interpersonal relationships) themes and differences based on trauma history, Vietnam experiences, and group membership are explored. We evaluate associations between themes and psychological well-being. Findings provide insight into experiences of this understudied group of women.     

‘Being young and LGBT,what could be worse?’ Analysis of youth LGBT activism in Indonesia: challenges and ways forward

Young Indonesian LGBT people are currently mobilising against a wave of conservatism and violence in an increasingly anti-LGBT context. Young LGBT people are showing remarkable courage and strategic thinking and mobilising in a range of ways. These include grassroot peer support, advocacy, and partnerships with government, adult-led non-government organisations and the private sector. However, these youth also face multiple challenges. This article highlights findings from a 2016 study of mobilisation by youth LGBT activists, using in-depth feminist qualitative research methods. The aim of the research was to highlight the resilience of young LGBT people in Indonesia, the barriers they face, and to consider what feminists and development policymakers and practitioners can do to support them.     

When Social Work and Psychoanalysis Meet

In this paper I share my personal journey from agency social worker to psychoanalyst. I show how I have brought to my psychoanalytic work the teachings of such well known social workers as Mary Richmond, Bertha Reynolds, Gordon Hamilton, and Florence Hollis as well those of such contemporary social workers as the late Gertrude and Rubin Blanck, Nancy Bridges, and Eda Goldstein, among others. In the presentation, I also consider how social work values, social work ethics and social work attitudes have influenced my approach to the practice of psychoanalysis. The attitudes which I refer to, include flexibility, beginning where the client is; an appreciation of the importance of understanding a patient’s cultural background and a recognition of the importance of the relationship in the therapeutic encounter. These were not standard for psychoanalysts at the time I began to practice. Today however psychoanalysis has largely caught up with social work, and this paper affirms how those of us who have had a social work background are well prepared for psychoanalysis in the 21st century.

The Great Regions: Wide Europe and China Make the Future Global Growth

EU is an economic super power and ASEAN is an economic mini power. In demographic view, EU is a mini power and ASEAN is a super power. EU has a kind of hydraulic power that no other institution has. Could it be that Europe as a whole is insulated against the sufferings and the fate of irreversible relative decline in the world? Perhaps like China, Europe need not be down and out forever. If one strategy is not working, more of the same is probably not the solution. So, Europe needs to do things differently—all depend on transparent governance and wiser policies.     

Risky business and geographies of refugee capitalism in the Somali migrant economy of Gauteng,South Africa

Research on migrant livelihoods in South Africa reveals links between social exclusion and migrant ‘cosmopolitan tactics’, including multi-sited socialities, diverse spatial business strategies and orientations precluding integration into a ‘xenophobic’ host society. Drawing on 10 months of ethnographic research, this study explores how Somali migrants’ business practices and tactics of mobility within and beyond Gauteng Province, South Africa (which encompasses Johannesburg and Pretoria) articulate with both broader transnational flows and investments in the local economy. Since the end of apartheid, Somalis and other migrants from the Horn of Africa have carved out an economic niche in peri-urban townships where high risk and frequent movement characterise workers’ lives. The Somali enclave in the neighbourhood of Mayfair, Johannesburg, links local and national circulations of people, goods and money to international circuits of the Somali ethnic economy—an economy that also involves non-Somali groups, mainly from Kenya and Ethiopia. These diverse dynamics of human mobility and financial circulation complicate bounded conceptualisations of transnationalism and also illustrate how tactical cosmopolitanisms may be grounded in spatial and social arrangements. The convergence of migrant mobility and financial flows produces distinctive patterns of livelihood embedded in a multi-scalar geography of movement, remittance, investment, risk and opportunity.