Random-effects models for analyzing clustered data from a nutrition education intervention

When evaluating the effects of public health intervention, larger units, or clusters, of individuals are often the unit of randomization and implementation. Ignoring dependency in the data due to clustering can misrepresent intervention effects. Random-effects models (REMs) may be a useful way to analyze such data. The present study compares results of analyses of data from a nutrition intervention program using four different methods: (a) usual multiple regression analysis using individual subject data, (b) usual multiple regression analysis using the classroom cluster as the unit of analysis, (c) two-level REM model with subjects clustered within classrooms, and (d) two-level REM model with subjects clustered within sites.     

Structure and Parameterization of Pharmacokinetic Models: Their Impact on Model Predictions

There has been an increasing interest in physiologically based pharmacokinetic (PBPK)models in the area of risk assessment. The use of these models raises two important issues: (1)How good are PBPK models for predicting experimental kinetic data? (2)How is the variability in the model output affected by the number of parameters and the structure of the model? To examine these issues, we compared a five-compartment PBPK model, a three-compartment PBPK model, and nonphysiological compartmental models of benzene pharmacokinetics. Monte Carlo simulations were used to take into account the variability of the parameters. The models were fitted to three sets of experimental data and a hypothetical experiment was simulated with each model to provide a uniform basis for comparison. Two main results are presented: (1)the difference is larger between the predictions of the same model fitted to different data se1ts than between the predictions of different models fitted to the dame data; and (2)the type of data used to fit the model has a larger effect on the variability of the predictions than the type of model and the number of parameters.     

Modified cramer-von mises and anderson-darling tests for weibull distributions with unknown location and scale parameters

The standard Cramer-von Mises and Anderson-Darling goodness-of-fit tests require continuous underlying distributions with known parameters. In this paper, tables of critical values are generated for both tests for Weibull distributions with unknown location and scale parameters and known shape parameters. The powers of the Cramer-von Mises, Anderson-Darling, Kolmogorov-Smirnov, and Chi-Square tests for this situation are investigated. The Cramer-von Mises test has most power when the shape is 1.0 and the Anderson-Darling test has most power when the shape is 3.5. Finally, a relation between critical value and inverse shape parameter is presented.