An Appeal to Aid Specialists

The appeal I am making is (roughly speaking) for aid specialists to do more to help those of us who are not aid specialists to arrive at judgments about the effects of the work of (voluntary) aid agencies that we have at least some reason to think accurate. I argue that the fact that it is so difficult for us to arrive at such judgments at present has certain negative consequences, and that this gives those who are in a position to make it easier for us to arrive at such judgments strong reasons to do so. And I argue that (certain) aid specialists are in such a position. Hence my appeal to them to do so.     

Keeping the family balance – adult daughters’ experiences of roles and strategies when supporting caring fathers

The Scandinavian countries represent a progressive approach to gender equality and transitions of traditional gender roles but little attention has been paid to gender equality in old age and how normative constructions of gender intersect in the lives of family carers. The aim of this study was to understand how adult daughters experience their roles and strategies when supporting fathers caring for an ill mother. A sample of eight daughters shared their experiences through in-depth interviews. The findings show that the daughters provide substantial and crucial effort and are intimately involved in the caring for their father and the sole contributors towards the emotional support of their fathers. They tend to devote a lot of energy towards picturing their family as ‘normal’ in terms of the family members adopting traditional roles and activities inside as well as outside the family context. In conclusion, the lack of understanding about gender as a ‘norm producer’ is something that needs to be further elaborated upon in order for professionals to encounter norm-breaking behaviours. The daughters’ position as family carers is often assumed and taken for granted since the intersecting structures that impact on the situations of the daughters are largely invisible.     

Implementation of a Bayesian adaptive design in a proof of concept study

With increased costs of drug development the need for efficient studies has become critical. A key decision point on the development pathway has become the proof of concept study. These studies must provide clear information to the project teams to enable decision making about further developing a drug candidate but also to gain evidence that any effect size is sufficient to warrant this development given the current market environment. Our case study outlines one such proof of concept trial where a new candidate therapy for neuropathic pain was investigated to assess dose-response and to evaluate the magnitude of its effect compared to placebo. A Normal Dynamic Linear Model was used to estimate the dose-response--enforcing some smoothness in the dose-response, but allowing for the fact that the dose-response may be non-monotonic. A pragmatic, parallel group study design was used with interim analyses scheduled to allow the sponsor to drop ineffective doses or to stop the study. Simulations were performed to assess the operating characteristics of the study design. The study results are presented. Significant cost savings were made when it transpired that the new candidate drug did not show superior efficacy when compared placebo and the study was stopped.     

Adverse Childhood Experiences and Disordered Gambling: Assessing the Mediating Role of Emotion Dysregulation

Adverse childhood experiences (ACEs), such as sexual and physical abuse, have been established as risk factors for the development of disordered gambling. The underlying mechanism by which ACEs influence disordered gambling, however, remains unknown. The aims of the present research were to comprehensively investigate ten types of childhood adversity and their relationships to disordered gambling in adulthood, and to test whether emotion dysregulation mediated the relationship between ACEs and disordered gambling. A sample of community gamblers (N = 414) completed self-report measures of ACEs, emotion dysregulation, and gambling severity. Results revealed a significant association between all but one type (physical abuse) of ACEs and disordered gambling. Further, the results highlighted the cumulative impact of ACEs on gambling. Specifically, individuals who experienced three or more types of ACEs were more than three times as likely to report disordered gambling as compared to individuals with no history of childhood adversity. Importantly, as hypothesized, emotion dysregulation mediated the relationship between ACEs and disordered gambling. Findings from this research describe the association between ACEs and gambling and indicate a causal link between childhood adversity and disordered gambling. Results suggest that treatment initiatives may do well to address both ACEs and emotion dysregulation in the treatment of problem gambling.     

Familism, Interparental Conflict, and Parenting in Mexican-Origin Families: A Cultural-Contextual Framework

The present investigation examined the relations between the cultural belief of familism and various aspects of family functioning and child adjustment, including interparental conflict, parenting, and children's attachment to school, in a sample of 549 two-parent Mexican-origin families. The results indicated that parents' familistic values were negatively associated with interparental conflict for both mothers and fathers. Parents' familistic values were also indirectly associated with parenting through the marital relationship. Interparental conflict was negatively associated with nurturant-involved parenting for both parents, but particularly for fathers. Interparental conflict had an indirect negative effect on children's attachment to school via mothers' and fathers' nurturant-involved parenting. Both paternal and maternal nurturant-involved parenting behaviors were positively associated with children's attachment to school across two time points. Child gender differences are also discussed.     

Discriminant Analysis Using Least Absolute Deviations

Several linear programming methods have been suggested as discrimination procedures. A least absolute deviations regression procedure is developed here which is simpler to use and does not suffer from any lack of invariance. A simulation study shows it to be at least as effective as any of the methods previously discussed for normal and heavy-tailed distributions.     

THE HERMITE DISTRIBUTION AS A MODEL OF DEMAND DURING LEAD TIME FOR SLOW-MOVING ITEMS

Heretofore, the Poisson and the Laplace distributions have been used to model demand during lead time for slow-moving items. In this paper, we present a Poisson-like distribution called the Hermite. The advantage of the Hermite is that it is as simple to use as the Poisson and the Laplace are. Moreover, the Hermite is the exact distribution of demand during lead time when unit demand is Poisson, P(Λ), and lead time is normally distributed, N(μ, σ²), so long as (μ/σ²)≥Λ. Thus, the Hermite can enhance the accuracy of analysis as well as add to the tools available to the analyst.