Sex differences in the development of mild cognitive impairment and probable Alzheimer’s disease as predicted by hippocampal volume or white matter hyperintensities

This study examined biological sex differences in the development of mild cognitive impairment (MCI) and probable Alzheimer’s disease (AD) development as predicted by changes in the hippocampus or white matter hyperintensities. A secondary data analysis of the National Alzheimer’s Coordinating Center Uniform Data Set was conducted. We selected samples of participants with normal cognition at baseline who progressed to MCI (n = 483) and those who progressed to probable AD (n = 211) to determine if hippocampal volume or white matter hyperintensities (WMH) at baseline predicted progression to probable AD or MCI and whether the rate of progression differed between men and women. The survival analyses indicated that changes in hippocampal volumes affected the progression to probable AD (HR = 0.535, 95% CI [0.300–0.953]) only among women. White men had an increased rate of progression to AD (HR = 4.396, CI [1.012–19.08]; HR = 4.665, 95% CI [1.072–20.29]) compared to men in other race and ethnic groups. Among women, increases in hippocampal volume ratio led to decreased rates of progressing to MCI (HR = 0.386, 95% CI [0.166–0.901]). Increased WMH among men led to faster progression to MCI (HR = 1.048. 95% CI [1.011–1.086]). Women and men who were older at baseline were more likely to progress to MCI. In addition, results from longitudinal analyses showed that women with a higher CDR global score, older age at baseline, or more disinhibition symptoms experienced higher odds of MCI development. Changes in hippocampal volumes affect the progression to or odds of probable AD (and MCI) more so among women than men, while changes in WMH affected the progression to MCI only among men.     

“Come for the period comics. Stay for the cultural awareness”: reclaiming the troll identity through feminist humor on Reddit’s /r/TrollXChromosomes

/r/TrollXChromosomes is a women-focused humor subreddit on the community site Reddit.com. This essay presents the findings of a thematic content analysis of TrollX’s top-ranked postings. Several themes emerge: that TrollX is a space for networked affective content, that postings often concern women’s embodiment and sexuality, and that they suggest feminist perspectives. These themes are all linked by the image of the troll: a remixed version of the negative, antisocial identity that disrupts and often harasses communities. The TrollX troll invokes a spirit of self-deprecation to revel in the absurdities of life and collectively celebrate women’s everyday experiences. However, this research also argues that the TrollX version of the feminist troll is only partially realized, as it tends to express ambivalence in regards to systemic, intersectional oppression.     

Multidimensional Analysis of Deprivation and Fragility Patterns of Migrants in Lombardy,Using Partially Ordered Sets and Self-Organizing Maps

Social Indicators Research - In this paper, we present a multidimensional fuzzy analysis of the levels and the patterns of poverty and social fragility of migrants’ families, in the Italian...     

The Women’s Empowerment in Livestock Index

Social Indicators Research - The empowerment of women in the livestock sector is fundamental to achieve gender equality. It also is instrumental for increased household productivity and improved...