Design priorities and disciplinary perspectives: the case of the US National Children's Study

Summary.  The National Children's Study (NCS), which was undertaken in 2000 by collaboration between several US federal government agencies, is one of the largest and boldest longitudinal studies of children's health ever undertaken. One of the key design issues has been the nature of the NCS sample. The paper describes the nature of the choices and the reasons for the decision that the NCS be based on a national probability sample. Designed as a study of the environmental influences on children's health and development, the NCS is expected to identify, enrol and follow about 100000 children from their birth to the age of 21 years. A broad definition of relevant environments of interest, and a full partnership between government, university and medical scientists, introduces considerable challenges in the design of the study.     

The Microfoundations of Dynamic Capabilities for Incremental and Radical Innovation in Knowledge-Intensive Businesses

We theorize and test the impact of two microfoundations of dynamic capabilities on incremental and radical innovation in knowledge-intensive businesses (KIBs). We argue that numerical flexibility and training, as human resources (HR) microfoundations that enable the configuration and deployment of resources, have different implications for incremental and radical innovation. Furthermore, we contend that those KIBs that make significant use of numerical flexibility will invest less in training, thus impacting innovation outcomes. We test our arguments using an original, longitudinal dyadic dataset assembled from 1750 structured interviews conducted with HR directors and senior managers in 875 KIBs located in Finland, France, Sweden and the UK. We find that numerical flexibility is negatively related to both incremental and radical innovation, whereas training is positively related to both. Our test of the moderating impact of training on both types of innovation resulting from the use of numerical flexibility was not statistically significant. Overall, we suggest that not all efforts by KIBs to mobilize resources and capabilities and align them with a complex external environment in the pursuit of innovation are necessarily beneficial. We highlight some research, policy, and practice implications that arise from our findings.     

Personalized Neural Networks Underlie Individual Differences in Ethnic Identity Exploration and Resolution

This study examined how ethnic identity relates to large-scale brain networks implicated in social interactions, social cognition, self-definition, and cognitive control. Group Iterative Multiple Model Estimation (GIMME) was used to create sparse, person-specific networks among the default mode and frontoparietal resting-state networks in a diverse sample of 104 youths aged 17–21. Links between neural density (i.e., number of connections within and between these networks) and ethnic identity exploration and resolution were evaluated in the full sample. Ethnic identity resolution was positively related to frontoparietal network density, suggesting that having clarity about one’s ethnic group membership is associated with brain network organization reflecting cognitive control. These findings help fill a critical knowledge gap about the neural underpinnings of ethnic identity.     

A meta-analytic framework to adjust for bias in external control studies

While randomized controlled trials (RCTs) are the gold standard for estimating treatment effects in medical research, there is increasing use of and interest in using real-world data for drug development. One such use case is the construction of external control arms for evaluation of efficacy in single-arm trials, particularly in cases where randomization is either infeasible or unethical. However, it is well known that treated patients in non-randomized studies may not be comparable to control patients—on either measured or unmeasured variables—and that the underlying population differences between the two groups may result in biased treatment effect estimates as well as increased variability in estimation. To address these challenges for analyses of time-to-event outcomes, we developed a meta-analytic framework that uses historical reference studies to adjust a log hazard ratio estimate in a new external control study for its additional bias and variability. The set of historical studies is formed by constructing external control arms for historical RCTs, and a meta-analysis compares the trial controls to the external control arms. Importantly, a prospective external control study can be performed independently of the meta-analysis using standard causal inference techniques for observational data. We illustrate our approach with a simulation study and an empirical example based on reference studies for advanced non-small cell lung cancer. In our empirical analysis, external control patients had lower survival than trial controls (hazard ratio: 0.907), but our methodology is able to correct for this bias. An implementation of our approach is available in the R package ecmeta .     

Generating inclusive services for children,youth and families: A shift to using complex systems theory

Service systems for children and families have been shaped by standard approaches to knowledge-building, which reflect a reductionist approach and assume linearity and/or that individuals and experiences are normally distributed. Yet, these approaches may be inadequate for clients most at-risk, especially those who would be analytic ‘outliers’. A complexity lens focuses on the whole system and seeks to identify patterns, including the dynamic interactions between components of the system. Social work scholars have begun to apply complexity theory to social work research efforts, demonstrating the conceptual potential of incorporating this theoretical approach into social work theories and models such as the person-in-environment framework and the ecosystems perspective. Yet, frameworks informed by complexity theory may require ontological and epistemological shifts in thinking and new methodological approaches in order to fully embody a complexity approach. Complexity theory offers the opportunity to consider social work clients who are most at-risk, as it is better suited for power law distributions. We can, therefore, reconceptualize the most ‘at-risk’ clients as being in a state of transition, which is also the space of most creativity and possibility.     

Basic relationships between human capital,migration and labour markets in the Western Balkans: An econometric investigation

The high outward mobility that characterises the countries in the Western Balkan region—already for three decades—is often seen as tightly linked to labour market imbalances and persistently low utilisation of human capital over time. To shed light on these issues we analysed the effects of labour market determinants and human capital endowment on migration and vice versa by estimating simultaneously a system of equations that accounted for such relationships in the context of WB countries. The period under analysis is 2007–2019 and the destination countries are the EU15. The empirical results confirm the importance of wage gaps and their changes as an important pull factor for driving emigration. In addition, gaps in human capital emerge as a powerful determinant for explaining emigration into countries where returns to human capital are relatively higher.     

Trauma and the effects of violence exposure and abuse on children: A review of the literature

A number of studies examining violence exposure in the passeveral years have been successful in linking physical abuse, sexual abuse, domestic violence, and community violence exposure to a wide variety of physiological, emotional, and behavioral problems manifested in short‐term, mid‐term, and long‐term effects. The literature on the effects of physical and sexual abuse is older than the research on children's exposure to domestic violence, which is a decade older than the research on the effects of community violence exposure on children. Despite the differences between the types of violence to which children are exposed, there are significantly similar findings, which point to a link between violence exposure and traumatization.     

REGULATING WORKERS COMPENSATION: THE MEDICO LEGAL EVALUATION OF INJURED WORKERS IN VICTORIA

Sociological research on occupational injury has been dominated by perspectives from the social organisation of work and the labour process. What is missing from this literature is an explanation of the actual experiences at the individual worker within the processes of legitimation of occupational injury. This study explores the experiences of injured workers as they move through the medico-legal process. Medical reports and clients perspectives were used to expose the positions of doctors, insurance companies, lawyers and workers compensation bureaucrats as they form a complex intersection of power and interest in the regulation of injured workers. In particular, the conflicting roles of doctors as both gatekeepers and service providers were highlighted in the maintenance of stigmatised damaged workers.