The Application of Genetic Information for Regulatory Standard Setting Under the Clean Air Act: A Decision-Analytic Approach

In 2002, the U.S. Environmental Protection Agency (EPA) released an “Interim Policy on Genomics,” stating a commitment to developing guidance on the inclusion of genetic information in regulatory decision making. This statement was followed in 2004 by a document exploring the potential implications. Genetic information can play a key role in understanding and quantifying human susceptibility, an essential step in many of the risk assessments used to shape policy. For example, the federal Clean Air Act (CAA) requires EPA to set National Ambient Air Quality Standards (NAAQS) for criteria pollutants at levels to protect even sensitive populations from adverse health effects with an adequate margin of safety. Asthmatics are generally regarded as a sensitive population, yet substantial research gaps in understanding genetic susceptibility and disease have hindered quantitative risk analysis. This case study assesses the potential role of genomic information regarding susceptible populations in the NAAQS process for fine particulate matter (PM_2.5) under the CAA. In this initial assessment, we model the contribution of a single polymorphism to asthma risk and mortality risk; however, multiple polymorphisms and interactions (gene‐gene and gene‐environment) are known to play key roles in the disease process. We show that the impact of new information about susceptibility on estimates of population risk or average risk derived from large epidemiological studies depends on the circumstances. We also suggest that analysis of a single polymorphism, or other risk factor such as health status, may or may not change estimates of individual risk enough to alter a particular regulatory decision, but this depends on specific characteristics of the decision and risk information. We also show how new information about susceptibility in the context of the NAAQS for PM_2.5 could have a large impact on the estimated distribution of individual risk. This would occur if a group were consequently identified (based on genetic and/or disease status), that accounted for a disproportionate share of observed effects. Our results highlight certain conditions under which genetic information is likely to have an impact on risk estimates and the balance of costs and benefits within groups, and highlight critical research needs. As future studies explore more fully the relationship between exposure, genetic makeup, and disease status, the opportunity for genetic information and disease status to play pivotal roles in regulation can only increase.     

The Relevance of Attachment Research for Adult Narratives Told in Psychotherapy

This paper discusses categories of attachment organization in infants, with an emphasis on the avoidant and disorganized/disoriented category. An example of how the avoidant infant attachment organization shows continuity throughout the lifespan is discussed. Finally, a case example of a man seen to have a dismissing/unresolved pattern of attachment organization is presented. In the ensuing discussion, the authors suggest that knowledge of infant attachment research can help therapists identify patterns that manifest in adult psychotherapy.     

Modified moment and maximum likelihood estimators for parameters of the three-parameter gamma distribution

This article is concerned with modifications of both maximum likelihood and moment estimators for parameters of the three-parameter gamma distribution. Modifications employed here are essentially the same as those previously considered by the authors (1980, 1981) in connection with the lognormal distribution. Sampling behavior of the estimates is indicated by a Monte Carlo simulation. For certain combinations of parameter values, these new estimators appear better than both maximum likelihood and moment estimators with respect to bias, variance and/or ease of calculation.     

Koordination durch heuristische Budgetierungsverfahren

If in companies decisions are decentralised coordination problems arise. Controlling offers different instruments for coordination. Among these, budgeting is very popular. In a centralized model it is shown how capacity allocation as well as transfer pricing coordinate under the constraints of budgeting. These two principles are combined with the process of budgeting in form of a top down, bottom up or counter current planning. From the resulting nine possible combinations only five are of practical relevance. These five cases are heuristics to the coordination problem, they are analysed by extensive example calculations. It is shown that transfer pricing coordinates better than capacity allocation and counter current planning is the dominant process of budgeting. The best results are obtained with transfer pricing closing with capacity allocation.     

Moral Panics and Urban Growth Machines: Official Reactions to Graffiti in New York City, 1990–2005

This paper analyzes the official response to graffiti writing in New York City throughout the 1990s and into the 21st century. Drawing from a variety of documents, such as newspaper articles, political press releases, internal memos and government reports, I show that the city’s reaction to graffiti constitutes a moral panic and that the significance of this response can be discerned when interpreted in the context of theoretical insights developed by urban sociologists. On this basis, I argue that moral panics, or at least a sub-set of panics, may be central to negotiating the social conflict that accompanies the ways in which (urban) space will be put to use.     

Statewide dissemination of trauma-focused cognitive-behavioral therapy (TF-CBT)

Despite evidence linking childhood trauma to subsequent social, emotional, psychological, and cognitive problems, many children who have experienced trauma do not receive mental health treatment that has been proven to be effective. Large-scale dissemination of evidence-based practices (EBPs) is one possible solution to enhance the current negative state of mental health treatment for these children. This article describes a dissemination effort of an EBP (i.e., Trauma-Focused Cognitive-Behavioral Therapy [TF-CBT]) for childhood symptoms of post-traumatic stress disorder throughout Arkansas. The effort targeted mental health professionals within child advocacy centers and community mental health centers across the state. The article describes the process of dissemination and implementation. Lessons learned and recommendations for future dissemination efforts are highlighted.     

Oppression Pedagogy: Intergroup Dialogue and Theatre of the Oppressed in Creating a Safe Enough Classroom

ABSTRACT

Creation of a classroom environment safe enough for students to expess their perspectives, hear classmates views and engage in classroom dialogue remains a major challenge in social work teaching. Intergroup dialogue and Theatre of the Oppressed are two approaches that effectively meet these challenges. Intergroup dialogue offers a systematic method of creating safety, exploring and owning social identity, engaging in hot topics, and ally building. Theatre of the Oppressed promotes communications that allow creative delving into sensitive topics. Data are presented from a cohort of students in a social work undergraduate oppression class. An ethnographic method was implemented to review student responses to a pedagogical approach that combined intergroup dialogue and Theatre of the Oppressed. Data analysis revealed students’ increased self-reflection and perspective taking.     

Listening/Nonverbal Communication Training

Multiculturalism increases communities' hopes of reducing racism and increasing productivity. Diversity training, however, is receiving negative criticism. Still, effective communication is viewed as critical. Thus, training in this area is encouraged. Cultural understanding and communication skills provide frameworks for developing tolerance and understanding. This study was conducted to provide more applied research to multicultural diversity with applications for business and education. Further, the purpose of this study was to analyze the influence of listening/nonverbal communication training on an individual's level of multicultural sensitivity. A statistically significant relationship was found between the listening/nonverbal communication training used in this study and multicultural sensitivity.     

Graffiti as a Form of Contentious Political Participation

Graffiti is a popular topic in the sociological, criminological, and linguistic literature with several book length treatments of various types of graffiti including tagging, gang graffiti, murals, and “bombings”. Yet, political sociologists have paid little attention to the role of graffiti as a form of contentious politics despite the often political nature of graffiti messages. As a result, most of the political research on graffiti is by non‐sociologists. We believe this is an oversight and that both political sociologists and social movement scholars need to seriously consider this form of micro‐level political participation. In this review we (1) demonstrate why some forms of graffiti should be considered a serious form of political participation; (2) compare and contrast graffiti to other forms of resistance including squatting and culture jamming; (3) review research findings on graffiti; and (4) discuss some of the conceptual and methodological challenges for doing graffiti research.