Therapeutic Hypothermia: Quantification of the Transition of Core Body Temperature Using the Flexible Mixture Bent‐Cable Model for Longitudinal Data

Hypothermia which is induced by reducing core body temperature is a therapeutic tool used to prevent brain damage resulting from physical trauma. However, all physiological systems begin to slow down due to hypothermia and this can result in increased risk of mortality. Therefore quantification of the transition of core body temperature to early hypothermia is of great clinical interest. Conceptually core body temperature may exhibit an either gradual or abrupt transition. Bent‐cable regression is an appealing statistical tool to model such data due to the model's flexibility and readily interpretable regression coefficients. It handles more flexibly models that traditionally have been handled by low‐order polynomial models (for gradual transition) or piecewise linear changepoint models (for abrupt change). We consider a rat model to quantify the temporal trend of core body temperature primarily to address the question: What is the critical time point associated with a breakdown in the compensatory mechanisms following the start of hypothermia therapy? To this end, we develop a Bayesian modelling framework for bent‐cable regression of longitudinal data to simultaneously account for gradual and abrupt transitions. Our analysis reveals that: (i) about 39% of rats exhibit a gradual transition in core body temperature; (ii) the critical time point is approximately the same regardless of transition type; and (iii) both transition types show a significant increase of core body temperature followed by a significant decrease.     

Emotion-Focused Couples Therapy and the Facilitation of Forgiveness

The goal of this study was to evaluate the effectiveness of an emotion-focused couple therapy intervention for resolving emotional injuries. Twenty couples acting as their own waitlist controls were offered a 10–12-session treatment to help resolve unresolved anger and hurt from a betrayal, an abandonment, or an identity insult that they had been unable to resolve for at least 2 years. Treated couples fared significantly better on all outcome measures over the treatment period compared to the waitlist period. They showed a significant improvement in dyadic satisfaction, trust, and forgiveness as well as improvement on symptom and target complaint measures. Changes were maintained on all of the measures at 3-month follow-up except trust, on which the injured partners deteriorated. At the end of treatment, 11 couples were identified as having completely forgiven their partners and six had made progress toward forgiveness compared with only three having made progress toward forgiveness over the waitlist period. The results suggest that EFT is effective in alleviating marital distress and promoting forgiveness in a brief period of time but that additional sessions may be needed to enhance enduring change.     

On the potential cost effectiveness of scientific audits

The rationale for the routine performance of scientific audits has been previously discussed, and it has been proposed that independent professionals audit scientific data just as certified public accountants in independent public accounting firms audit financial data (1–4). Scientific audits would typically require the examination of data in laboratory notebooks and other work sheets, upon which research publications are based. Examples of such audits have been publicized recently, although these represent audits which have been conducted relatively inefficiently, over periods of several years per audit, and which have only been conducted due to the persistence of whistleblowers suspecting scientific fraud (5, 6). A detailed report has also appeared on the results of an audit of the research activities of a particular individual, where the audit was limited solely to an examination of the research publications themselves for errors and discrepancies (7). It should be emphasized that the purpose of conducting scientific audits is not only to detect fabrication of experimental results but also to monitor presumably more prevalent, non‐fraudulent, inappropriate practices, such as misrepresentation of data, inaccurate reporting, and departure from institutional guidelines for handling hazardous materials, working with human subjects, etc.

Two concerns which have been raised concerning the performance of scientific audits relate to cost. What would they cost, and who would pay for them? These questions, however, may be turned around. What does it cost not to conduct such audits, and who pays for that? An assumption often made is that science is self‐correcting, that sooner or later the truth will be revealed because of the need to replicate experiments of others for independent verification of novel findings (8). Testimony recently presented at a U.S. congressional hearing suggests that the self‐correcting manner in which science advances represents a very slow and inefficient process for uncovering scientific fraud (5, 6, 9). Data from a survey of university scientists was also presented, indicating “. . . a reluctance to take prompt, corrective action not only when an investigator suspects another of misconduct but also should the investigator discover flaws in his or her own published reports‐whether the flaws were the result of honest error or fraud”; (10).

The uncritical acceptance by established scientists that the self‐correcting process works compounds the problem. The Editor of Science has written that”;. . . 99.9999 percent of reports are accurate and truthful. . .”; (8). If indeed only 0.0001% of published reports were inaccurate or untruthful, there would be little justification for scientific audits. However, congressional testimony from the National Institutes of Health (NIH) revealed that”;. . . the NIH Director's office has handled an average of 15–20 allegations and reports of misconduct annually in its extramural programs, which supports the work of approximately 50,000 scientists”; (11). As I shall attempt to demonstrate, since NIH alone receives fraud‐related complaints concerning the work of at least 0.03% of scientists it supports in other institutions, and since evidence indicates that the incidence of fraud is considerably greater than 0.03% (10, 12), the need to audit data is justifiable on the basis of being cost effective.     

Encoding dissimilarity data for statistical model building

We summarize, review and comment upon three papers which discuss the use of discrete, noisy, incomplete, scattered pairwise dissimilarity data in statistical model building. Convex cone optimization codes are used to embed the objects into a Euclidean space which respects the dissimilarity information while controlling the dimension of the space. A “newbie” algorithm is provided for embedding new objects into this space. This allows the dissimilarity information to be incorporated into a smoothing spline ANOVA penalized likelihood model, a support vector machine, or any model that will admit reproducing kernel Hilbert space components, for nonparametric regression, supervised learning, or semisupervised learning. Future work and open questions are discussed. The papers are:     

Whose Wishes and Feelings? Children's Autonomy and Parental Influence in Family Court Enquiries

The importance of the child’s right to be heard and fortheir wishes and feelings to be taken notice of is now acceptedacross a broad professional and research terrain. Increasingly,children are being treated as active participants in the processesand decisions that affect them. In cases of divorce and separation,especially where parental relationships are conflicted, theaccepted wisdom in the UK for many years has been for childrento be protected rather than empowered. More recently, practitioners,policy makers and researchers have looked for ways to involvechildren, although the ‘welfare’ of the child hasremained paramount. In this context, the question of how toensure that wishes and feelings expressed are those that authenticallybelong to the child, rather than to their parent, sibling orother, has achieved a new significance. This article presentsfindings from recent research to illustrate how the tensionbetween protection and empowerment is being played out in thisaspect of welfare report enquiries carried out by CAFCASS (Childrenand Family Court Advisory and Support Service) private law practitioners.     

Gambling and Adverse Life Events Among Urban Adolescents

This study explored the cross sectional association between adverse life events and gambling in a sample of 515 urban adolescents (average age 17, 55% male, 88% African American). Approximately half of the sample had gambled in the past year (51%); 78% of the gamblers gambled monthly and 39% had a gambling-related problem. On the other hand, 88% of the sample had experienced at least one life event in the past year, and those experiencing events tended to live in more disadvantaged neighborhoods. The mere acknowledgement of experiencing a stressful life event in the past year (yes/no) was not associated with an increase in odds of being a gambler, with gambling more frequently, or with having a gambling problem. However, when the context of the event was considered, an association was found between directly experiencing threatening and deviant/violent types of events and frequent gambling (OR > 2). Additionally, the probability of being a gambler increased as the number of events experienced increased (aOR = 1.07, 95% CI = 1.01, 1.13, P = 0.013), but problems among gamblers were not associated with the number of events experienced (aOR = 1.01, 95% CI = 0.92, 1.11, P = 0.876). During adolescence, life events appear to be connected more with the frequency of gambling rather than with problems related to gambling.     

Measuring Love: Sexual Minority Male Youths' Ideal Romantic Characteristics

Research examining how sexual minorities characterize love within same-sex relationships is scarce. In this study, we examined the validity of Sternberg's Triangular Theory of Love in a sample of sexual minority male youth (N = 447). To test the adequacy of the theory for our population, we examined the psychometric properties of the Triadic Love Scale (TLS) and tested whether the three underlying constructs of the theory (Intimacy, Passion, and Commitment) emerged when participants were asked to consider their ideal relationship with another man. Using confirmatory factor analysis (CFA), we found support for the three-factor solution to characterize sexual minority male youths' ideal romantic relationship, after minimizing item cross-loadings and adapting the content of the Passion subscale. We discuss the implications of our findings regarding the measurement of the TLS among sexual minority male youth and propose ways to enhance its measurement in future research.