Penalized multidimensional fitting for protein movement detection

The three-dimensional structure of a given protein can take different conformations depending upon the reaction it undergoes and its substrate/cofactor/partners binding state. Various methods exist to study these conformational changes but only one, called DynDom, is clearly focused on movement detection. An alternative method is proposed, making use of multivariate data analysis, called ‘penalized Multidimensional Fitting (penalized MDF)’ based on penalized movements of points in order to approach the distances between points after movement to the distances given by the reference matrix. The objective is to detect the amino acids that undergo an important movement by fitting the distances of one conformation to the distances of the second one by modifying only the coordinates of the first one. This method is applied to three different proteins.     

Longitudinal Change in Adolescent Depression and Anxiety Symptoms from before to during the COVID-19 Pandemic

This study aimed to examine changes in depression and anxiety symptoms from before to during the first 6 months of the COVID-19 pandemic in a sample of 1,339 adolescents (9–18 years old, 59% female) from three countries. We also examined if age, race/ethnicity, disease burden, or strictness of government restrictions moderated change in symptoms. Data from 12 longitudinal studies (10 U.S., 1 Netherlands, 1 Peru) were combined. Linear mixed effect models showed that depression, but not anxiety, symptoms increased significantly (median increase = 28%). The most negative mental health impacts were reported by multiracial adolescents and those under ‘lockdown’ restrictions. Policy makers need to consider these impacts by investing in ways to support adolescents’ mental health during the pandemic.     

With a focus on well-being and capabilities

Most of the applied research on capabilities and well-being makes use of quantitative data and research techniques. This paper examines the possibilities of qualitative data gathering to explore the theoretical richness (and complexity) of the capabilities framework. With this objective, the capabilities theory is translated into a framework that enables focus group discussions on well-being. It turns out to be surprisingly easy to discus issues related to the theory of capabilities, as the concepts are recognizable for the focus participants.Being able to choose and making trade offs is related to the concepts of well-being of the participants. Provided one has ‘the basic capability to cope with capabilities’, possibilities and choices increases well-being. These findings show that the capability framework can be fruitfully used for applied research on well-being and that qualitative data gathering creates opportunities that are complementary to quantitative techniques.     

A SNP,Gene, and Polygenic Risk Score Approach of Oxytocin‐Vasopressin Genes in Adolescents’ Loneliness

Not much is known regarding underlying biological pathways to adolescents’ loneliness. Insight in underlying molecular mechanisms could inform intervention efforts aimed at reducing loneliness. Using latent growth curve modeling, baseline levels and development of loneliness were studied in two longitudinal adolescent samples. Genes (OXTR, OXT, AVPR1A, AVPR1B) were examined using SNP‐based, gene‐based, and polygenic risk score (PRS) approaches. In both samples, SNP‐ and gene‐based tests showed involvement of the OXTR gene in development of loneliness, though, significance levels did not survive correction for multiple testing. The PRS approach provided no evidence for relations with loneliness. We recommend alternative phenotyping methods, including environmental factors, to consider epigenetic studies, and to examine possible endophenotypes in relation to adolescents’ loneliness.     

Externalizing Problem Behavior in Adolescence: Parenting Interacting With DAT1 and DRD4 Genes

This study extends previous gene‐by‐environment (G × E) research through design and methodological advances and examines alternative hypotheses of diathesis stress, vantage sensitivity, and differential susceptibility. In a sample of 984 adolescents and their parents, we examined whether effects of parental support, proactive, punitive, harsh punitive, and psychological control on externalizing problem behavior are moderated by adolescents' genotype for the dopamine transporter (DAT1) or receptor D4 (DRD4) gene. Results provided evidence for main effects of parenting behavior and DRD4, and multiple interaction effects of which one survived Bonferroni correction. Adolescents carrying a long DRD4 variant were more susceptible to the effects of parental proactive control on aggression, for better and for worse. Critical considerations were made regarding the complexity of G × E research.     

Career Sidestep,Wage Setback? The Impact of Different Types of Employment Interruptions on Wages

We examined the wage implications of different types of wage employment interruptions in a sample of 44,384 Belgian employees. The employment interruption types included are family leave, unemployment, self‐employment, educational leave and a category other interruptions (for example, travel, voluntary work). We conduct separate analyses for men and women. Results indicate that unemployment spells and family breaks are penalized by lower subsequent wages, while the wage impact of self‐employment spells and educational leave is insignificant. Family breaks and unemployment spells were found to be more harmful for men than for women. Implications of the results and directions for future research are discussed.     

Transmission and inequality of wealth: An empirical study of wealth mobility from 1800 to 1938 in France

This paper endeavors to measure the intergenerational transmission of wealth inequalities over the 1800–1938 period. For this purpose, we have consulted historical data composed of wealth genealogies covering the 19th and first half of the 20th centuries. The database was created from families included in the “3,000 families” survey of those individuals residing in the Loire-Inférieure département. The empirical study reveals a relatively large degree of intergenerational immobility: those whose father had twice the average level of wealth themselves upon death leave behind 1.45 times the average wealth of their generation.     

Identity Styles and Interpersonal Behavior in Emerging Adulthood: The Intervening Role of Empathy

This study examined the intervening role of empathy in the relations between identity styles (i.e., information‐oriented, normative, and diffuse‐avoidant styles), and inter‐personal behaviors (i.e., prosocial behavior, self‐ and other‐oriented helping, and physical and relational aggression). In a sample of 341 emerging adults, it was found that an information‐oriented style relates to a more adaptive pattern of interpersonal behaviors whereas a normative or a diffuse‐avoidant identity style relate to a more maladaptive pattern of interpersonal behaviors. Empathy played an intervening role between the information‐oriented style and interpersonal behavior, and between the diffuse‐avoidant style and interpersonal behavior. However, empathy did not intervene between the normative style and interpersonal behavior. Implications for future research are discussed.     

Psychotropic drug classification based on sleep–wake behaviour of rats

Summary.  The aim of the paper is to present methodology for the classification of potential psychotropic drugs on the basis of their activity. We first sketch the background of this class of drugs and then zoom in on so-called pharmacoelectroencephalogram studies. These data pose some statistical challenges. For classification purposes, we propose a flexible hierarchical discriminant analysis tool, allowing us to take the specific nature of the drug class into account, as well as the features of the mixed models, in combination with fractional polynomials, fitted to the electroencephalogram data. The method is evaluated against the background of existing methods. The method's performance is studied by using a comprehensive analysis of a large electroencephalogram data set.