PI3K pathway and Bcl-2 family. Clinicopathological features in prostate cancer

The phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathways and Bcl-2 family play a central role in prostate cancer (PC). The aim was to determine influence in the biochemical progression in PC. To evaluate the association between clinic pathological and immunohistochemical variables, Spearman’s test was performed. Log-rank test and Kaplan–Meier curves were used for survival comparisons. To explore the correlation of the studied immunohistochemical parameters and the established prognostic variables with biochemical progression, univariate and multivariate Cox proportional Hazard regression analyses were performed. Spearman analysis showed correlation between stroma expression and tumor expression of PI3K with biochemical progression (p?=?.009, p?=?.004), respectively, and tumor immunohistochemical score with biochemical progression (p?=?.051). In the multivariate Cox regression model, only PI3K was retained as independent predictors of biochemical progression. In stroma expression, PI3K is (HR 0.172, 95% CI 0.065–0.452, p?=?.000); tumor expression, PI3K is (HR 0.087, 95% CI 0.026–0.293, p?=?.000), and tumor immunohistochemical score (HR 0.382, 95% CI 0.209–0.697 p?=?.002). Our results suggest a role for prostatic expression of PI3K was prognostic markers for PC. PI3K/AKT/mTOR and Bcl-2 family are becoming an important therapeutic target and predictive biomarkers of onset and progression of PC.     

Mechanisms Linking Self-Regulation and Sexual Behaviors in Never-Married Young Adults

Little is known about specific mechanisms linking self-regulation to sexual risk taking. The present study considered four possibilities in emerging adulthood: sexual self-restraint, consideration of future consequences, substance use, and romantic competence. Never-married young adults (N = 274), ages 18 to 24, responded to anonymous Internet surveys (60.2% female, 78.8% European American, 66.3% university students). The effects of self-regulation were primarily indirect but varied by sexual behavior, suggesting that high self-regulation limits sexual risk via high sexual self-restraint and low substance use. High regulation was linked to multiple sexual partners and high-risk practices risk via high romantic competence, high self-regulation was linked to multiple sexual partners and high risk practices.     

Prevalence and Risk Factors Among Minors for Online Sexual Solicitations and Interactions With Adults

The research on online child sexual victimization has mainly focused on the sexual solicitation of minors (i.e., sexual requests by an adult), with scarce information available on sexual interactions (e.g., cybersex or meeting in person) in which a minor is exploited by an adult. In the present study, we analyzed the prevalence and risk factors associated with both sexual solicitations and interactions of minors with adults. The sample included 2,731 minors between 12 and 15 years old (50.6% female). The minors completed several self-report questionnaires about sexual solicitations and interactions with adults, including possible risk factors (e.g., sociodemographic variables, Internet use, and psychological adjustment). Of the participants, 15.6% of girls and 9.3% of boys reported sexual solicitations, and 8.2% of girls and 7.4% of boys reported sexualized interactions with adults. Among the variables studied, several appeared related to both sexual solicitations and interactions: older age, having been involved in sexting, being a victim of cyberbullying, having unknown people in friends list, using chat, time spent online on a weekday, and depression symptoms. Gender (being female), using video chat, and instant messaging by computer were significant variables for sexual solicitation but not for sexual interaction; participation in online games was significant only for sexual interactions. Finally, minors reporting sexual interactions presented a higher risk profile than those reporting only sexual solicitations. These findings highlight the relevance of distinguishing between sexual solicitations and sexual interactions and suggest important avenues for prevention programs.     

Predicting attitudes and behavioural intentions towards social entrepreneurship: the role of servant leadership in young people / Predicción de las actitudes y las intenciones conductuales hacia el emprendimiento social: el papel del liderazgo de servicio en los jóvenes

: Social entrepreneurship (SE) refers to the development of innovative projects whose main aim is not individual profit but the transformation of society. The issue is particularly important for promoting youth development and participation. This research offers insights from two studies designed from a multi-dimensional perspective analysing attitudes and behavioural intentions towards social ventures built upon the constructs of servant leadership and lifestyles. Results of Study 1 indicated that servant leadership is a key predictor of attitudes and behavioural intentions towards social entrepreneurship, while having a violent lifestyle is negatively associated with these attitudes and intentions. Study 2 showed that servant leadership style predicted attitudes towards social entrepreneurship over and above other types of leadership (i.e., transformational, transactional and laissez-faire). These studies demonstrate the importance of considering servant leadership and relational styles as key factors in predicting attitudes and behavioural intentions regarding social and active participation of young people. Limitations of the study and applications to designing interventions aimed at improving attitudes and behavioural intentions towards social entrepreneurship are discussed.     

Identifying Priorities for Aging Policies in Two Portuguese Communities

The aging population has an impact on health, social, and economic issues in regard to individuals, communities, and organizations. The challenge for local policies in response to aging is to create sufficient resources to meet the population’s needs, wishes, and rights as people age. Active aging constitutes one of the guiding perspectives on policies. Taking into account the local governance perspective, the Model for Aging Local Policies Analysis (MALPA) was created in order to convert the active aging paradigm into a practical approach, as a technique to evaluate and analyze local aging policies. In this research, the MALPA instrument was applied in two Portuguese communities (Coruche and Oeiras). The objective was to identify the intervention priorities of aging policies in both communities, determining whether the instrument can facilitate the development of proposals for the improvement of local aging policies. It was possible to evaluate the communities and programs, identifying the least appropriate policy actions regarding the intervention priorities. The results allowed us to identify 10 priorities about collaborative governance, involvement of the elderly in the policy-making process, lifelong learning, economic hardship, policies for all ages, isolated vulnerable and fragile groups, intergenerational contacts, safety in all policies, labor opportunities, and conditions and transport network improvement.     

Assessing driver's mental representation of Adaptive Cruise Control (ACC) and its possible effects on behavioural adaptations

The introduction of Adaptive Cruise Control (ACC) could be very helpful for making the longitudinal driving task more comfortable for the drivers and, as a consequence, it could have a global beneficial effect on road safety. However, before or during the usage of the device, due to several reasons, drivers might generate in their mind incomplete or flawed mental representations about the fundamental operation principles of ACC; hence, the resulting usage of the device might be improper, negatively affecting the human-machine interaction and cooperation and, in some cases, leading to negative behavioural adaptations to the system that might neutralise the desirable positive effects on road safety. Within this context, this paper will introduce the methodology which has been developed in order to analyse in detail the topic and foresee, in the future, adequate actions for the recovery of inaccurate mental representations of the system.     

Using Quality of Life Criteria to Define Urban Areas in Catalonia

The purpose of this paper is to develop the concept and definition of multidimensional urban areas, thereby providing insights into our understanding of the sub-regional structures of household spatial systems. Hence, we propose a framework for strategic planning that considers several areas of household needs. In order to achieve this goal, we develop a multicriteria methodology to define the territorialisation of the region of Catalonia (Spain). We first analyse the different methodologies used to define territorial areas based on economic criteria, for example, those used to construct travel-to-work areas (TTWA), among other methods. Thus, in practice several criteria and techniques are used to organize a territory, including administrative areas, commuting-based algorithms, and gravitational techniques. Finally, these points help us build a system of multicriteria urban areas that is consistent with the overall use of time by individuals.

Conflict, Consensus, and Coalition: Economic and Workforce Development Strategies for African Americans and Latinos

Any work toward racial equity in America will need to include strengthening the black–Latino coalition. While there are political and social tensions between these groups, much of the underlying issue involves real and perceived perceptions of economic competition, particularly the notion that immigrant Latinos undercut African American wages. We note that there is some evidence that immigrants pull down incomes of US-born unskilled workers—both black and Latino. We argue, however, that highly restrictive immigration policy will have minimal effects and erode collective political power; a superior alternative is working together to reduce high school dropout rates, raise the minimum wage, reintegrate ex-offenders, rigorously enforce antidiscrimination law, promote comprehensive immigration reform, and pursue community development. Such an analysis is gaining ground in grassroots efforts to build trust and forge policy coalitions between Latinos and African Americans.     

Evidence-Based Practice in Social Work: Challenges and Opportunities for Clinicians and Organizations

Evidence-based practice (EBP) is increasingly emphasized in social work, yet effective approaches for translating research evidence into social work practice remain elusive. Despite a growing body of evidence describing effective interventions with a variety of populations, social workers continue to encounter substantial challenges with incorporating knowledge gained from these intervention studies into their routine practice with clients. This paper presents the current research outlining the known barriers and promoters to using EBP in social work clinical practice. Because social workers practice within the context of organizations, we consider the barriers that exist at both the individual and organizational levels that affect clinical social work practice. In addition to addressing the various challenges to incorporating research evidence into practice, we will also discuss a variety of emergent opportunities accompanying the move toward EBP that can be leveraged by clinicians in their social work practice with clients.     

Psychometric properties of the Spanish version of the activism and radicalism intention scale / Propiedades psicométricas de la versión española de la escala de intención de activismo y radicalismo

The purpose of this study is to adapt the Activism and Radicalism Intention Scale to Spanish. To do so, two studies were performed. In the first, which had a sample of 514 participants, the instrument was adapted to Spanish and a confirmatory factorial analysis was conducted. The psychometric results obtained were similar to those of the original version, and the scale’s two-dimensional structure was replicated. In the second study, the psychometric characteristics of the original instrument were also replicated, but in this case with a sample of 133 participants comprised of sympathizers and activists in the 15-M anti-austerity movement. Regarding the validity of the scale, both studies provide evidence on the coherence of the construct in terms of both its internal structure and its theoretical relationship with other psychosocial variables. The reliability of the instrument obtained in both samples studied was acceptable. In short, this study presents a tool in Spanish which can be useful for studying individuals’ and groups’ predisposition towards more or less violent political mobilization.