Conflict of Interest Mitigation Procedures May Have Little Influence on the Perceived Procedural Fairness of Risk‐Related Research

Two between‐subject experiments explored perceived conflict of interest (COI)—operationalized as perceived procedural unfairness—in a hypothetical public–private research partnership to study the health risks of trans fats. Perceived fairness was measured as subjects’ perceptions that health researchers would be willing to listen to a range of voices and minimize bias (i.e., COI) in the context of a research project. Experiment 1 (n = 1,263) randomly assigned research subjects to a partnership that included (1) a combination of an industry partner, a university partner, and a nongovernmental organization (NGO) partner; and (2) one of three processes aimed at mitigating the potential for COI to harm the quality of the research. The procedures included an arm's‐length process meant to keep the university‐based research team from being influenced by the other partners, an independent advisory board to oversee the project, and a commitment to making all data and analyses openly available. The results suggest that having an industry partner has substantial negative effects on perceived fairness and that the benefit of employing a single COI‐mitigation process may be relatively small. Experiment 2 (n = 1,076) assessed a partnership of (1) a university and either an NGO or industry partner and (b) zero, one, two, or three of the three COI‐mitigation procedures. Results suggest there is little value in combining COI‐mitigation procedures. The study has implications for those who aim to foster confidence in scientific findings for which the underlying research may benefit from industry funding.     

Distress in Emerging Adults: Further Evaluation of the Painful Feelings About Divorce Scale

Young adults from divorced families experience clear emotional distress despite most not meeting diagnostic criteria for emotional disorders. Laumann-Billings and Emery (2000) developed the Painful Feelings About Divorce (PFAD) scale to assess the emotional distress emerging adults feel regarding childhood parental divorce. The study sample is undergraduates predominately between the ages of 18 and 22. This study adds to the literature by (a) further demonstrating the PFAD scale reliability and validity, (b) including participants with both divorced and separated but never married parents, and (c) assessing generalizability of the PFAD with a more diverse socioeconomic sample.     

Meaningful work at a distance: A case study in a hospital

Having a positive impact on other people's lives typically increases the likelihood of regarding one's work as meaningful. In some settings, however, employees have little or no contact to those who experience the impact of their work. Our paper examines how such distance affects these employees' construction of their work as meaningful. We present the findings of an in-depth case study of medical laboratory workers who do not typically interact with their patients. Drawing on interviews and observational data, we identify three sensemaking practices through which employees overcome the physical and perceived psychological distance to patients: assembling various pieces of information about the patient, sharing patient-related stories with colleagues, and relating themselves to patients and their medical problems. We also find that overcoming distance to patients can result in emotional stress, which is why some employees prefer staying at a ‘safe’ psychological distance. Our paper contributes to the meaningful work literature by examining how actors make work meaningful when they are physically distant from their object of work. We also contribute to a critical understanding of meaningful work by showing how efforts to render one's work more meaningful can intensify stress and emotional tension.     

The intergenerational transmission of human capital: the role of skills and health

We provide new evidence on some of the mechanisms reflected in the intergenerational transmission of human capital. Applying both an adoption and a twin design to rich data from the Swedish military enlistment, we show that greater parental education increases sons’ cognitive and non-cognitive skills, as well as their health. The estimates are in many cases similar across research designs and suggest that a substantial part of the effect of parental education on their young adult children’s human capital works through improving their skills and health.     

Nested combination tests with a time‐to‐event endpoint using a short‐term endpoint for design adaptations

Adaptive trial methodology for multiarmed trials and enrichment designs has been extensively discussed in the past. A general principle to construct test procedures that control the family‐wise Type I error rate in the strong sense is based on combination tests within a closed test. Using survival data, a problem arises when using information of patients for adaptive decision making, which are under risk at interim. With the currently available testing procedures, either no testing of hypotheses in interim analyses is possible or there are restrictions on the interim data that can be used in the adaptation decisions as, essentially, only the interim test statistics of the primary endpoint may be used. We propose a general adaptive testing procedure, covering multiarmed and enrichment designs, which does not have these restrictions. An important application are clinical trials, where short‐term surrogate endpoints are used as basis for trial adaptations, and we illustrate how such trials can be designed. We propose statistical models to assess the impact of effect sizes, the correlation structure between the short‐term and the primary endpoint, the sample size, the timing of interim analyses, and the selection rule on the operating characteristics.     

Analytic bias correction for maximum likelihood estimators when the bias function is non-constant

Recently, many articles have obtained analytical expressions for the biases of various maximum likelihood estimators, despite their lack of closed-form solution. These bias expressions have provided an attractive alternative to the bootstrap. Unless the bias function is “flat,” however, the expressions are being evaluated at the wrong point(s). We propose an “improved” analytical bias-adjusted estimator, in which the bias expression is evaluated at a more appropriate point (at the bias adjusted estimator itself). Simulations illustrate that the improved analytical bias-adjusted estimator can eliminate significantly more bias than the simple estimator, which has been well established in the literature.     

A Neuropsychoanalytic Approach to Case Studies

Neuropsychoanalysis is an interdisciplinary field that attempts to generate links between psychoanalytic schools and the neurosciences. Historically speaking, neuropsychoanalysis emerged as a response to ‘cognitive’ views of the mind/brain problem, which tended to neglect the influence of emotional and instinctual processes in the constitution, and functioning, of the human mind. Since its origins, neuropsychoanalysis has used case studies, of brain injured individuals undergoing psychoanalytic treatment, to explore how focal damage to specific brain areas is related to changes in non-cognitive domains of the mind, such as emotion, motivation or personality. This approach is a useful contribution to the neurosciences since it allows observing, at the same time, objective and subjective aspects of the mind/brain, thus bridging third and first person methodologies. In this article a neuropsychoanalytic approach to case studies is introduced, describing both its historical roots as well as its present status. Then, a brief case study, of a man with focal damage to the left dorso-lateral prefrontal cortex, who presented with changes in his capacity to intrinsically regulate feelings, is used to exemplify this approach.     

(Trans)Gender Role Expectations and Child Care in Samoa

Samoan transgendered males are known as fa'afafine. Although Samoan women are characterized as the primary child care providers, fa'afafine report elevated willingness to invest in nieces and nephews compared to men and women. We hypothesized that Samoans hold unique transgender role expectations such that fa'afafine are expected to invest more toward nieces and nephews compared to others. Participants (N = 214) included Samoan men (30.23 years ±8.19), women (30.00 years ±10.93), and fa'afafine (30.25 years ±7.45). For a variety of child care activities, participants nominated men, women, fa'afafine, or all three of these categories of individuals as responsible for investing toward nieces and nephews. Participants also reported how frequently their family members asked them to perform these activities for nieces and nephews. Responsibility for performing these activities was typically designated for women; men and women viewed fa'afafine as least responsible. Men's, but not fa'afafine's, family members asked them to allocate investment toward nieces and nephews more frequently. These findings are not consistent with the transgender role expectation hypothesis. Discussion details how the findings contribute to the literature on child care in Samoa. Alternate hypotheses for explaining why fa'afafine report elevated willingness to invest in nieces and nephews are considered.