Assessment of Health Risk from Historical Use of Cosmetic Talcum Powder

This study's objective is to assess the risk of asbestos‐related disease being contracted by past users of cosmetic talcum powder.  To our knowledge, no risk assessment studies using exposure data from historical exposures or chamber simulations have been published. We conducted activity‐based sampling with cosmetic talcum powder samples from five opened and previously used containers that are believed to have been first manufactured and sold in the 1960s and 1970s.  These samples had been subject to conflicting claims of asbestos content; samples with the highest claimed asbestos content were tested.  The tests were conducted in simulated‐bathroom controlled chambers with volunteers who were talc users.  Air sampling filters were prepared by direct preparation techniques and analyzed by phase contrast microscopy (PCM), transmission electron microscopy (TEM) with energy‐dispersive x‐ray (EDX) spectra, and selective area diffraction (SAED).  TEM analysis for asbestos resulted in no confirmed asbestos fibers and only a single fiber classified as “ambiguous.”  Hypothetical treatment of this fiber as if it were asbestos yields a risk of 9.6 × 10^?7 (under one in one million) for a lifetime user of this cosmetic talcum powder.  The exposure levels associated with these results range from zero to levels far below those identified in the epidemiology literature as posing a risk for asbestos‐related disease, and substantially below published historical environmental background levels.  The approaches used for this study have potential application to exposure evaluations of other talc or asbestos‐containing materials and consumer products.     

The Effects of Community Pluralism on Press Coverage of Health Risks from Local Environmental Contamination

Based on the conflict/consensus model of Tichenor, Donohue and Olien, we proposed that mass mediated information signalling that local agents are contaminating the local environment and posing health risks is conflict-generating information and, therefore, will be controlled in the interest of community stability. We expected such control to vary by community structure. A content analysis of nine months of coverage by 19 newspapers supported the hypothesis that papers in more pluralistic communities were more likely than papers in less pluralistic communities to link contamination from local agents to threats to human health in the community and to frame such stories as problems. Newspapers in less pluralistic communities were more likely to frame local contamination in the context of solutions to the problem and were more likely to link contamination to health risks if the contamination were in a distant community.     

Regional mobility of economists: An extension

We extend Davis and Patterson’s analysis of the incidence and determinants of regional mobility of Ph.D. economists. By exploiting previously collected data, we identify the patterns of regional mobility not only at the point of entry into the labor market for economists who received their doctoral degree in 1968 but also the net mobility of these economists over a 25-year period. The net effects of regional mobility decisions made between graduation in 1968 and year-25 employment in 1993, and between initial professional employment in 1969 and year-25 employment in 1993, are analyzed. Our results suggest that many economists demonstrate a propensity to“nest“ in their degree and first-job regions of employment and that those employed in government service and those with a greater diversity of work experience are more likely to migrate across regions during their careers.     

Research records and the resolution of misconduct allegations at research universities

Accurate record keeping is an important part of the responsible conduct of research. However, there is very little empirical research on scientific record keeping. No one knows the incidence of serious problems with research records, the types of problems that occur, nor their consequences. In this study, we examined the role of research records in the resolution of misconduct allegations as a useful barometer for the incidence and types of problems that occur with records. We interviewed Research Integrity Officers (RIOs) at 90 major research universities and conducted focus groups with active research faculty. RIOs reported problems with research records in 38% of the 553 investigations they conducted. Severe problems with research records often prevented completion of investigations while problems that are more typical lengthened them by 2 to 3 weeks. Five types of poor record keeping practices accounted for 75 % of the problems with incomplete/inadequate records being the most common (30%). The focus groups concurred with the findings from the interviews with RIOs, stressed the importance of the research group leader in setting and maintaining record practices, and offered additional insights. While university officials and faculty members have suspected for many years that there are serious problems with research record keeping, our study provides empirical evidence for this belief. By documenting some of the problems with record keeping in university-based research, the results of our study provide information that will be useful for policy development at academic institutions.     

The Injurious Relationship Between Racial Microaggressions and Physical Health: Implications for Social Work

ABSTRACT

In recent years, the study of racial microaggressions (or subtle forms of racial discrimination) has increased significantly in the social sciences, particularly highlighting the negative impact of racial microaggressions on individuals’ mental health. Despite this, there is a dearth of literature that has examined the relationship between racial microaggressions and physical and psychological health. Using two self-reported measures—the Racial and Ethnic Microaggressions Scale (REMS) and the RAND 36-Item Short Form Health Survey—with a diverse group of participants (N = 277), results suggest that racial microaggressions are significantly correlated with poorer health conditions. Furthermore, racial microaggressions were found to predict various types of physical health conditions, such as general health problems, pain, lower energy levels, and fatigue. Finally, different types of microaggressions (e.g., microaggressions in school or the workplace, environmental microaggressions) were found to be predictors of specific health issues. Implications for social work are discussed.     

Conservative Politics,Sacred Cows,and Sacrificial Lambs: The (Mis)Use of Evidence in Canada's Political and Penal Fields

This article explores the federal government's justifications for its decision to cancel Canada's prison farm program, and demonstrates how Harper's Conservatives used talk of “evidence,” “science,” and “research” to appear to be performing good, modern governance. We argue that developments within the penal field are deeply intertwined with activities within the political field—and are more clearly understood when situated within the broader context of politics, science, and the strategic (mis)use of evidence. Scholars must be careful in assuming the state is actually engaging evidence rather than doing so only at the level of rhetoric and discourse. Cet article explore les justifications utilisées par le gouvernement fédéral par rapport à sa décision d'annuler le programme canadien de prisons‐fermes, et démontre comment les conservateurs d'Harper ont utilisé les notions d’‘évidence’, de ‘science’ et de ‘recherche’ pour donner une apparence de bonne performance et de gouvernance moderne. Nous affirmons que les développements du champ pénal sont profondément imbriqués avec les activités à l'intérieur du champ politique—et sont mieux comprises lorsque situés dans le cadre plus large des politiques, de la science et des stratégies de (mal)utilisation d’évidences. Les spécialistes devraient être prudents lorsqu'ils assument que l’État prend réellement en compte les évidences alors qu'il est en fait seulement au niveau de la rhétorique et du discours.     

Landmark estimation of survival and treatment effects in observational studies

Clinical studies aimed at identifying effective treatments to reduce the risk of disease or death often require long term follow-up of participants in order to observe a sufficient number of events to precisely estimate the treatment effect. In such studies, observing the outcome of interest during follow-up may be difficult and high rates of censoring may be observed which often leads to reduced power when applying straightforward statistical methods developed for time-to-event data. Alternative methods have been proposed to take advantage of auxiliary information that may potentially improve efficiency when estimating marginal survival and improve power when testing for a treatment effect. Recently, Parast et al. (J Am Stat Assoc 109(505):384–394, 2014) proposed a landmark estimation procedure for the estimation of survival and treatment effects in a randomized clinical trial setting and demonstrated that significant gains in efficiency and power could be obtained by incorporating intermediate event information as well as baseline covariates. However, the procedure requires the assumption that the potential outcomes for each individual under treatment and control are independent of treatment group assignment which is unlikely to hold in an observational study setting. In this paper we develop the landmark estimation procedure for use in an observational setting. In particular, we incorporate inverse probability of treatment weights (IPTW) in the landmark estimation procedure to account for selection bias on observed baseline (pretreatment) covariates. We demonstrate that consistent estimates of survival and treatment effects can be obtained by using IPTW and that there is improved efficiency by using auxiliary intermediate event and baseline information. We compare our proposed estimates to those obtained using the Kaplan–Meier estimator, the original landmark estimation procedure, and the IPTW Kaplan–Meier estimator. We illustrate our resulting reduction in bias and gains in efficiency through a simulation study and apply our procedure to an AIDS dataset to examine the effect of previous antiretroviral therapy on survival.     

Social documentary and personal investigations in contemporary South African photography: Tracey Derrick’s “One in Nine” series

A shell of white gauze floats against a split background in Tracey Derrick’s 2009 photograph, Inhabit – Habergeon – middle English, piece of armour to protect the neck and chest (Inhabit), both autonomous and materially frail. The shadowed wall lifts the calcified gauze towards the viewer, as its lithe body hovers above the vertical divide that separates light from dark. This position apart from the edge may be read as a passage missed or overcome. A year of invasive treatment following her diagnosis of stage two breast cancer in March of 2008 led South African documentary photographer Tracey Derrick to create a photographic series that combines her humanist sensibility with personal reflections on illness. Derrick represents meditations on her trajectory through illness in “One in Nine: My Year as a Statistic,” a collection of reposeful digital colour photographs – including Inhabit – that features the cast Derrick made to obtain accurate measurements for her prosthesis. This body of work complicates a widely held assumption that post-apartheid photography in South Africa focuses more on the individual than collective societal issues. Derrick’s unusual series warrants methodological treatment that attends to the complex ways in which the visual vocabulary and concerns of apartheid-era documentary photography overlap with the personal explorations associated with post-1994 photographic production. In this paper, I utilise socio-historical, psychoanalytic and phenomenological readings of Tracey Derrick’s photograph and “One in Nine” series to elicit an interpretation of the image and series as statement of agency within a metaphorical battle against an invisible, yet pervasive disease. By reading Derrick’s photograph through these theoretical lenses, I reveal her image to be a metaphoric assertion of tenacity and Derrick’s agency, and highlight the areas of overlap between Derrick’s documentary practice and her more personal “One in Nine” project.