Post-finasteride syndrome – does it really exist?

Abstract

Inhibitors of 5α-steroid reductase are drugs used to treat androgen-dependent conditions including prostate diseases and androgenic alopecia. Finasteride was the first on the market and is currently the most widely used inhibitor. Dutasteride was the second inhibitor to be approved and has a similar safety profile. Common adverse events of treatment consist of sexual disorders and a negative affect balance. It was described that the prolonged use of 5α-steroid reductase inhibitors in patients with alopecia can cause persistent side effects called a post-finasteride syndrome (PFS), that is not just a simple coexistence of events, but rather a definite syndrome with an iatrogenic background. PFS occurs in susceptible individuals even after small doses of the drug and can last for a long time after the discontinuation of treatment. A deterioration in the quality of life in affected individuals does not justify use of the drug. Wider recognition of PFS symptoms, its incidence, course, prevention, and treatment possibilities will allow the indications for drug use to be reconsidered and treatment to be more personalized. Knowledge about PFS will also help to provide the best treatment for affected individuals and to properly educate patients before obtaining an informed consent for therapy with 5α-steroid reductase inhibitors.     

Post-Separation Conflict Trajectories: A Longitudinal Study

Although previous studies have shown that parental separation and parental conflict contribute independently to the adaptation difficulties of young people, there is, as of yet, no precise portrait of how post-separation conflicts evolve. Indeed, some fundamental questions remain unanswered: (1) Do parents who experience few conflicts during their break-up continue to enjoy a harmonious relationship afterward? (2) When parents have a conflictual relationship in the first years after separating, do problems eventually subside? (3) Are a family's characteristics associated with the way a post-separation conflict evolves? The present, exploratory study attempts to provide some answers to these three questions. The sample was composed of 123 boys and girls from 8 to 11 years old. The children and their parents were interviewed on two separate occasions at a 1-year interval. The first interview (time 1) took place 2.5 years after the separation on average. The children were notably asked to give their perception of the parental conflict. Four post-separation conflict trajectories were brought to light. Analysis also targeted three more-specific variables that distinguished these conflict trajectories, namely family income, quality of the relationship with the mother, and the degree of agreement at the time of separation.     

Private property and the problem of the miraculous: the kramats and the city of Cape Town

This paper seeks to explore the place of kramats the graves of Muslim saints or Auliyah – in the landscape of contemporary Cape Town. The kramat sites have been proclaimed as heritage sites because of their importance as tangible signs of Islam at the Cape. At the same time, the process of the kramats becoming heritage sites has contained moments of intense, often sensational, public contestation. Offering a reading of the discourses surrounding two contested kramats in Cape Town, this paper explores the way kramats mark out a miraculous space in the prosaic modern city and introduce into the post-apartheid evaluation of heritage, alternative conceptions of space and notions of temporality. They are sites of impossibility where, it is claimed, the laws of nature themselves are interrupted to mark the intangible particularities of the site. This paper explores what happens when this miraculous space is subject to the demands of private property and municipal law and the conflicts that arise from this collision of different conceptual and experiential modalities. It considers the effects of the entanglement of legend and history that result from the production of these sites as heritage in a market-driven economy.     

Family Benefits and Fertility: An Econometric Analysis

A population's growth potential is significantly underestimated by conventional calculations of population momentum which assume an immediate drop to replacement level fertility. Here we assume that the growth rate of births linearly declines to zero over a specified time interval, and find simple and intuitively meaningful expressions for the size of the ultimate birth cohort and the resultant population momentum. In particular, we find that the increase in the number of births over the transition is equal to growth at the initial rate for half the time needed to attain a constant birth level. Thus our formula readily calculates the growth potential of a population under a gradual approach to stationarity without the need for a numerical projection. Calculations for actual and hypothetical populations are presented to show the demographic impact of such gradual approaches to zero growth.     

Multidimensional Measurement of Poverty Among Women in Sub-Saharan Africa

Since the seminal work of Sen, poverty has been recognized as a multidimensional phenomenon. The recent availability of relevant databases renewed the interest in this approach. This paper estimates multidimensional poverty among women in fourteen Sub-Saharan African countries using the Alkire and Foster multidimensional poverty measures, whose identification method is based on a counting approach. Four dimensions are considered: assets, health, schooling and empowerment. The results show important differences in poverty among the countries of the sample. The multidimensional poverty estimates are compared with some alternative measures such as the Human Development Index, income poverty, asset poverty and the Gender-related Development Index. It is found that including additional dimensions into the analysis leads to country rankings different from those obtained with the mentioned four measures. Decompositions by geographical area and dimension indicate that rural areas are significantly poorer than urban ones and that a lack of schooling is, in general, the highest contributor to poverty. The paper also conducts robustness and sensitivity analyses of the multidimensional estimates with respect to the number of dimensions in which deprivation is required in order to be considered poor, as well as to the poverty lines within each dimension. Several cases of dominance between countries are found in the first robustness test.