Defining the linear portion of a sigmoid‐shaped curve: bend points

Formulae are provided that define the ‘bend points’, the beginning and end of the essentially linear dose–response region, for the four‐parameter logistic model. The formulae are expressed in both response and dose units. The derivation of the formulae is shown in order to illustrate the general nature of the methodology. Examples are given that describe how the formulae may be used while planning and conducting bioassays. Copyright © 2003 John Wiley & Sons, Ltd.     

Exposure Reconstruction for the TCDD-Exposed NIOSH Cohort Using a Concentration- and Age-Dependent Model of Elimination

Recent studies demonstrating a concentration dependence of elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suggest that previous estimates of exposure for occupationally exposed cohorts may have underestimated actual exposure, resulting in a potential overestimate of the carcinogenic potency of TCDD in humans based on the mortality data for these cohorts. Using a database on U.S. chemical manufacturing workers potentially exposed to TCDD compiled by the National Institute for Occupational Safety and Health (NIOSH), we evaluated the impact of using a concentration- and age-dependent elimination model (CADM) (Aylward et al., 2005) on estimates of serum lipid area under the curve (AUC) for the NIOSH cohort. These data were used previously by Steenland et al. (2001) in combination with a first-order elimination model with an 8.7-year half-life to estimate cumulative serum lipid concentration (equivalent to AUC) for these workers for use in cancer dose-response assessment. Serum lipid TCDD measurements taken in 1988 for a subset of the cohort were combined with the NIOSH job exposure matrix and work histories to estimate dose rates per unit of exposure score. We evaluated the effect of choices in regression model (regression on untransformed vs. ln-transformed data and inclusion of a nonzero regression intercept) as well as the impact of choices of elimination models and parameters on estimated AUCs for the cohort. Central estimates for dose rate parameters derived from the serum-sampled subcohort were applied with the elimination models to time-specific exposure scores for the entire cohort to generate AUC estimates for all cohort members. Use of the CADM resulted in improved model fits to the serum sampling data compared to the first-order models. Dose rates varied by a factor of 50 among different combinations of elimination model, parameter sets, and regression models. Use of a CADM results in increases of up to five-fold in AUC estimates for the more highly exposed members of the cohort compared to estimates obtained using the first-order model with 8.7-year half-life. This degree of variation in the AUC estimates for this cohort would affect substantially the cancer potency estimates derived from the mortality data from this cohort. Such variability and uncertainty in the reconstructed serum lipid AUC estimates for this cohort, depending on elimination model, parameter set, and regression model, have not been described previously and are critical components in evaluating the dose-response data from the occupationally exposed populations.     

A Numerical Solution to the Nonhomogeneous Two-Stage MVK Model of Cancer

In this article, we describe a straightforward method for solving the probability of at least one malignant cell by time t, and the associated hazard function, in the general (i.e., nonhomogeneous) two-stage Moolgavkar-Venzon-Knudson (MVK) model of cancer. The method consists of solving four coupled ordinary differential equations derived from the Kolmogorov backward equations for this process. The relationship of this method to previously proposed solutions is discussed.     

Happiness has traitlike and statelike properties: A reply to Veenhoven

Veenhoven (1994) contrasted hypotheses of whether happiness is a trait or state, concluding that it is a state variable. This article critiques the conceptual foundation of Veenhoven's paper, and examines technical deficiencies in his review of evidence. Based on previous findings and new analyses, we conclude that happiness has both traitlike and statelike properties, but that individual differences in happiness endure despite its situational reactivity, and explain greater variance than situational effects.     

Evaluation: Stakeholder-focused Criteria

Identifying and selecting suitable criteria is an important consideration in evaluating the performance of public sector organizations. Which criteria are chosen, and how they are weighted, will depend largely on the perspective being taken; different stakeholders (for example, clients, providers or commissioners) are likely to emphasize different criteria. In this paper a number of criteria are identified and an argument is developed to indicate which criteria are likely to be valued by various stakeholders. Furthermore, a number of approaches and mechanisms for evaluation are identified and the links between these, the criteria appropriate to them and the various stakeholders are made explicit. Finally, the issue of politics and the distribution of power between the stakeholders is addressed with a call for greater explicitness in using and balancing criteria (for example, as between professionals and the intended beneficiaries of services). In this way, while recognizing the inherent political nature of performance evaluation, the planning and implementation of services may be improved by a more mutually informed approach to evaluation.     

A comparison of indicators for evaluating x-11-arima seasonal adjustment

Summary The evaluation of the performance of seasonal adjustment procedures is an issue of practical importance in view of the unobservable nature of the components. Looking at just one indicator when judging the overall quality of a procedure may be misleading, even though this is common practice when many series are involved. The main purpose of this paper is to compare the information content of different synthetic indicators with reference to the X-11-ARIMA procedure. Sixty-six different types of monthly seasonal series are generated and the seasonal component then extracted by carrying out X-11-ARIMA with standard options. The correlation between the pseudo-true error for each series and various synthetic indicators allows us to compare the latter's reliability, under both the hypotheses of minimum and maximum variance of the pseudo-true seasonal component. We show that the overall quality indexQ-the indicator most commonly adopted by users of the X-11-ARIMA-is always outperformed by the simpler diagnostics based on the stability of the estimates. In particular, the “sliding-spans” indicator, proposed by Findley et al. (1990) and included in the diagnostics of the new X-12 procedure, shows a much stronger correlation with the pseudo-true error in the seasonal adjustment. We also show that the total forecasting errors in the one-year-ahead extrapolation of the seasonal component have a good informative power and perform almost as well as the “sliding-spans” indicator.     

Interpersonal dependency of preferences

Standard decision theoretic models disregard the phenomenon of interpersonal dependency of preferences. In this paper it is argued that interpersonal dependency of preferences is a serious challenge for standard utility theory. First we sketch the more philosophical aspects of the problem and then, using a simple, formal model for the two-person case, we show that interpersonal dependency of preferences generally results in indeterminacy of preferences (resp. of subjective utility).     

Exploring structure-effectiveness relationships in nonprofit arts organizations

The authors examined nineteen nonprofit performing arts organizations, investigating the distribution of influence among organizational members, the grouping of volunteers and staff in organizational structures, and the effectiveness of the organizations. The organizations' effectiveness was assessed using multiple performance indicators. The analysis revealed five groupings or configurations of influence, which correlated to the organizations exhibiting the highest and lowest levels of organizational effectiveness. The authors conclude that a variety of structures are associated with good performance but structural dysfunctions are associated with organizational failure, and that members' commitment to an organization's structure is an important element of success.     

Leslie matrix models

A review of the Leslie matrix model theory and its literature 1941-1987 is presented. The point of view is that of a mathematician who focuses on the parts of the theory which are relevant to demography. Works of a decidedly applied nature are not dealt with.     

The impact of social networks on the occupational status of migrants

This paper postulates that there is a continuous exchange of information and knowledge between those who share the common bond of having migrated to the US. The individual components of this information exchange constitute social networks. The 2 hypotheses tested are 1) immediate social networks and people known in the US facilitate the flow of information both to new migrants and between established migrants, thus promoting upward social mobility; and 2) access to broader network ties, organization membership, extra-ethnic friendships, and familiarity with established institutions smooths the transition process, resulting in increased social position. The data used comes from a study conducted in 1982-1983 in 4 Mexican sending communities (2 rural, 2 urban), for a total of 440 migrants. Results show that migrants in every socioeconomic bracket reported access to some or all social network characteristics. There was contact with either a family member or acquaintances from the migrants' town of origin. Over 50% of migrants reported knowing many fellow townspeople. Twice as many migrants belong to a sports club as to a social or religious organization. Very few rural migrants report knowing no townspeople, while 32% of urban migrants claim no knowledge of fellow migrants from their town of origin. Urban origin migrants report more contacts with those of other ethnicity than rural migrants. Those employed in agriculture are least acquainted with social information and contacts, while those in skilled and service sectors are well acquainted with them. The results of fact and analysis show that 1) access to personal US networks results in an average 4.4 point advantage in occupational prestige scores over no access, and 2) utilizing institutional US networks combined with any cumulative US experience gives a migrant a 5 point advantage over a fellow migrant with identical experience level but no institutional network contacts. This is also true for institutional Mexican networks. Thus success or failure in migrating is partly due to migrants' societal infrastructure and the fact that available information and social networks are accessed and utilized differently by different migrants.