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31.
  总被引:1,自引:0,他引:1  
A pragmatic quantitative risk assessment (QRA) of the risks of waterborne Cryptosporidium parvum infection and cryptosporidiosis in immunocompetent and immunodeficient French populations is proposed. The model takes into account French specificities such as the French technique for oocyst enumeration performance and tap water consumption. The proportion of infective oocysts is based on literature review and expert knowledge. The probability of infection for a given number of ingested viable oocysts is modeled using the exponential dose-response model applied on published data from experimental infections in immunocompetent human volunteers challenged with the IOWA strain. Second-order Monte Carlo simulations are used to characterize the uncertainty and variability of the risk estimates. Daily risk of infection and illness for the immunocompetent and the immunodeficient populations are estimated according to the number of oocysts observed in a single storage reservoir water sample. As an example, the mean daily risk of infection in the immunocompetent population is estimated to be 1.08 x 10(-4) (95% confidence interval: [0.20 x 10(-4); 6.83 x 10(-4)]) when five oocysts are observed in a 100 L storage reservoir water sample. Annual risks of infection and disease are estimated from a set of oocyst enumeration results from distributed water samples, assuming a negative binomial distribution of day-to-day contamination variation. The model and various assumptions used in the model are fully explained and discussed. While caveats of this model are well recognized, this pragmatic QRA could represent a useful tool for the French Food Safety Agency (AFSSA) to define recommendations in case of water resource contamination by C. parvum whose infectivity is comparable to the IOWA strain.  相似文献   
32.
While the anonymization of biological samples and data may help protect participant privacy, there is still debate over whether this alone is a sufficient safeguard to ensure the ethical conduct of research. The purpose of this systematic review is to examine whether the review of an ethics committee is necessary in the context of anonymized research, and what the considerations in said ethics review would be. The review of normative documents issued by both national and international level organizations reveals a growing concern over the ability of anonymization procedures to prevent against reidentification. This is particularly true in the context of genomic research where genetic material’s uniquely identifying nature along with advances in technology have complicated previous standards of identifiability. Even where individual identities may not be identifiable, there is the risk of group harm that may not be protected by anonymization alone. We conclude that the majority of normative documents support that the review of an ethics committee is necessary to address the concerns associated with the use of anonymized samples and data for research.  相似文献   
33.
This paper aims to evaluate the private and social gains of shareholder activism in an optimal contracting framework involving dispersed shareholders who may become active. The social gains are based on the welfare to stake holders in the firm, whereas the private gains are based on shareholder wealth only. Active shareholders influence the contracting game with the CEO, and therefore also the size and the distribution of the surplus to be split between the shareholders and the CEO. Although the model is very simple and focussing on the creation and distribution of welfare between the shareholders and the CEO, we nonetheless identify surprising divergence between the private and social profitability of shareholder activism. Shareholder activism that is privately profitable is not necessarily socially profitable. The distributional effects of shareholder activism may dominate the efficiency effects to make shareholder activism a negative social NPV project.   相似文献   
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35.
Testing Hypotheses in the Functional Linear Model   总被引:2,自引:0,他引:2  
The functional linear model with scalar response is a regression model where the predictor is a random function defined on some compact set of R and the response is scalar. The response is modelled as Y =Ψ( X )+ ɛ , where Ψ is some linear continuous operator defined on the space of square integrable functions and valued in R . The random input X is independent from the noise ɛ . In this paper, we are interested in testing the null hypothesis of no effect, that is, the nullity of Ψ restricted to the Hilbert space generated by the random variable X . We introduce two test statistics based on the norm of the empirical cross-covariance operator of ( X , Y ). The first test statistic relies on a χ 2 approximation and we show the asymptotic normality of the second one under appropriate conditions on the covariance operator of X . The test procedures can be applied to check a given relationship between X and Y . The method is illustrated through a simulation study.  相似文献   
36.
On the interaction between heterogeneity and decay in two-way flow models   总被引:1,自引:0,他引:1  
In this article, we examine the role played by heterogeneity in the popular ??connections model?? of Jackson and Wolinsky (J Econ Theory 71(1):355?C365, 1996). We prove that when heterogeneity with respect to the values of resources, or the information decay parameter, depends on the identity of the player who forms the link, and the player who receives the link, all networks can be supported as Nash. Moreover, we show that Nash networks may not always exist. Interestingly, in the absence of decay, neither result occurs in a model with value heterogeneity. Finally, we show that when reducing heterogeneity, all networks cannot be supported as Nash, and the non-existence problem also disappears.  相似文献   
37.
    
Sample entropy (SaEn) was recently developed to quantify the amount of regularity in data. However, the computation of this feature in an online application is infeasible. In this work, we examine a heuristic approach using permuted limited number of samples to estimate SaEn and discuss estimation variability in this context. We conclude that the computation of permuted SaEn provides a fair estimate of time series regularity that can be used in online applications.  相似文献   
38.
    
It has been recently demonstrated that mindfulness-based intervention may be particularly suitable for addressing sexual difficulties in women. Although the Five-Facet Mindfulness Questionnaire (FFMQ) is currently one of the most widely used scales to assess mindfulness, no adaptation and validation of the FFMQ to measure female sexual functioning has been published. The main aim of this study was to develop and validate a sexual version of the Five Facets Mindfulness Questionnaire (FFMQ-S) to specifically measure mindfulness in the context of sexual encounters. A total of 251 healthy, French-speaking female volunteers were administered the FFMQ-S, the original FFMQ, and the Female Sexual Distress Scale (FSDS-R). Confirmatory factor analyses indicated that the FFMQ-S exhibits a five-factor model, as implied by the original FFMQ. Good scale reliability was observed. The FFMQ-S showed significant correlations with the FSDS-R and the usual FFMQ. Scores on the FFMQ-S correlated significantly more negatively with the total FSDS-R score than with the total score of the original version of the FFMQ. These findings clearly support the relevance of developing a version of the FFMQ tailored to sexual functioning.  相似文献   
39.
This article examines residents’ perceptions of inner-city revitalization in legacy cities. The analysis focuses on neighborhoods undergoing revitalization in a legacy city, Buffalo, NY. The article draws from data for a larger research project called Turning the Corner which was sponsored by the Urban Institute. The focus of that project was to identify planning strategies to address negative externalities caused by neighborhood change and heightened risks of displacement due to revitalization. Data were collected through a series of focus groups with residents and stakeholders in working-class, minority neighborhoods which were identified as being in the early stages of revitalization. Two findings emerged from the analysis. First, residents perceived urban revitalization to have a destabilizing effect on traditional neighborhoods. Second, residents perceived revitalization as detrimental to the sustainability of family-friendly neighborhoods. Insights from the analysis are used to prompt planners’ advocacy for revitalization strategies aimed at protecting minority, working-class neighborhoods when institutionally driven revitalization occurs.  相似文献   
40.
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