A Bayesian Adjustment for Covariate Misclassification with Correlated Binary Outcome Data

Estimated associations between an outcome variable and misclassified covariates tend to be biased when the methods of estimation that ignore the classification error are applied. Available methods to account for misclassification often require the use of a validation sample (i.e. a gold standard). In practice, however, such a gold standard may be unavailable or impractical. We propose a Bayesian approach to adjust for misclassification in a binary covariate in the random effect logistic model when a gold standard is not available. This Markov Chain Monte Carlo (MCMC) approach uses two imperfect measures of a dichotomous exposure under the assumptions of conditional independence and non-differential misclassification. A simulated numerical example and a real clinical example are given to illustrate the proposed approach. Our results suggest that the estimated log odds of inpatient care and the corresponding standard deviation are much larger in our proposed method compared with the models ignoring misclassification. Ignoring misclassification produces downwardly biased estimates and underestimate uncertainty.     

几种传输线的场分布

求开放平板线、外正三角形內圆同轴线、外方內圆同轴线、外正六边形內圆同轴线的特性阻抗而建立的精确保角变换的基础上,本文进一步讨论了显式逆变换函数,从而求得了这几种传输线的场分布的闭合表达式。由于所用保角变换的精确性,所得的显式场分布在内导体和外导体的内接圆尺寸之比小于0.5in。基本上是准确的,在这个尺寸比稍大些时也可作为参考。这些场分布对于了解传输线的功率容量,计算衰减常数,考虑功率耦合,设计有关的有源器件等都是必不可少的。文中获得的几种传输线的场分布的显著特点是计算方便,在一般实用范围內有足够的精度。     

总量函数与精确指数的关系研究

一、问题的提出指数是一个古老且为大家熟悉的经济分析方法。在复杂经济系统中,对于不同商品的总体,在数量上往往是不能直接加总的,要综合测定其变动程度,只有通过引进一个同度量因素,使之过渡到可以直接加总的综合指标,而后进行不同区域间或不同时期的对比,来测定...     

Non-parametric Estimation of the Residual Distribution

Consider a heteroscedastic regression model Y = m ( X ) +σ( X )ε, where the functions m and σ are smooth, and ε is independent of X . An estimator of the distribution of ε based on non-parametric regression residuals is proposed and its weak convergence is obtained. Applications to prediction intervals and goodness-of-fit tests are discussed.     

Percentile Related Bounds and Estimator for the Mean of the Negative Binomial Distribution

Upper and lower bounds are obtained for the mean of the negative binomial distribution. These bounds are simple functions of a percentile determined by the shape parameter. The result is then used to obtain a robust estimate of the mean when the shape parameter is known.     

Dependence Between Two Diagnostic Tests with Copula Function Approach: A Simulation Study

The study of the dependence between two medical diagnostic tests is an important issue in health research since it can modify the diagnosis and, therefore, the decision regarding a therapeutic treatment for an individual. In many practical situations, the diagnostic procedure includes the use of two tests, with outcomes on a continuous scale. For final classification, usually there is an additional “gold standard” or reference test. Considering binary test responses, we usually assume independence between tests or a joint binary structure for dependence. In this article, we introduce a simulation study assuming two dependent dichotomized tests using two copula function dependence structures in the presence or absence of verification bias. We compare the test parameter estimators obtained under copula structure dependence with those obtained assuming binary dependence or assuming independent tests.     

Graphical and Numerical Methods for Detecting Influential Observations in Complex Bingham Data

We describe methods to detect influential observations in a sample of pre-shapes when the underlying distribution is assumed to be complex Bingham. One of these methods is based on Cook's distance, which is derived from the likelihood of the complex Bingham distribution. Other method is related to the tangent space, which is based on the local influence for the multivariate normal distribution. A method to detect outliers is also explained. The application of the methods is illustrated in both a real dataset and a simulated sample.     

Statistical Certification of Software Systems

Common software release procedures based on statistical techniques try to optimize the trade-off between further testing costs and costs due to remaining errors. We propose new software release procedures where the aim is to certify with a certain confidence level that the software does not contain errors. The underlying model is a discrete time model similar to the geometric Moranda model. The decisions are based on a mix of classical and Bayesian approaches to sequential testing and do not require any assumption on the initial number of errors.     

Small sample study on estimators of life distributions and of mean survival times using randomly censored data

Whereas large-sample properties of the estimators of survival distributions using censored data have been studied by many authors, exact results for small samples have been difficult to obtain. In this paper we obtain the exact expression for the ath moment (a > 0) of the Bayes estimator of survival distribution using the censored data under proportional hazard model. Using the exact expression we compute the exact mean, variance and MSE of the Bayes estimator. Also two estimators ofthe mean survival time based on the Kaplan-Meier estimator and the Bayes estimator are compared for small samples under proportional hazards.     

A Bivariate Generalization of Gamma Distribution

In this article, a bivariate generalisation of the gamma distribution is proposed by using an unsymmetrical bivariate characteristic function; an extension to the non central case also receives attention. The probability density functions of the product and ratio of the correlated components of this distribution are also derived. The benefits of introducing this generalized bivariate gamma distribution and the distributions of the product and the ratio of its components will be demonstrated by graphical representations of their density functions. An example of this generalized bivariate gamma distribution to rainfall data for two specific districts in the North West province is also given to illustrate the greater versatility of the new distribution.