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81.
Robert J. Mitkus David B. King Mark O. Walderhaug Richard A. Forshee 《Risk analysis》2014,34(4):735-750
The use of thimerosal preservative in childhood vaccines has been largely eliminated over the past decade in the United States because vaccines have been reformulated in single‐dose vials that do not require preservative. An exception is the inactivated influenza vaccines, which are formulated in both multidose vials requiring preservative and preservative‐free single‐dose vials. As part of an ongoing evaluation by USFDA of the safety of biologics throughout their lifecycle, the infant body burden of mercury following scheduled exposures to thimerosal preservative in inactivated influenza vaccines in the United States was estimated and compared to the infant body burden of mercury following daily exposures to dietary methylmercury at the reference dose established by the USEPA. Body burdens were estimated using kinetic parameters derived from experiments conducted in infant monkeys that were exposed episodically to thimerosal or MeHg at identical doses. We found that the body burden of mercury (AUC) in infants (including low birth weight) over the first 4.5 years of life following yearly exposures to thimerosal was two orders of magnitude lower than that estimated for exposures to the lowest regulatory threshold for MeHg over the same time period. In addition, peak body burdens of mercury following episodic exposures to thimerosal in this worst‐case analysis did not exceed the corresponding safe body burden of mercury from methylmercury at any time, even for low‐birth‐weight infants. Our pharmacokinetic analysis supports the acknowledged safety of thimerosal when used as a preservative at current levels in certain multidose infant vaccines in the United States. 相似文献
82.
83.
The Experience-Earnings Profile: Productivity-Augmenting or Purely Contractual? Evidence from the UK
William J. Moore Robert J. Newman Geoffrey K. Turnbull 《Journal of Labor Research》2007,28(3):417-435
We test the human capital interpretation of the experience-earnings profile. Does the upward sloping portion of the experience-earnings
profile reflect on-the-job training which in turn causes the experience-productivity profile to slope upwards, or do purely
contractual factors determine the nature of life-cycle earnings. Herein, we provide additional evidence on the relationship
between productivity and earnings by examining earnings differentials in the UK academic labor market for economists. Using
a test first suggested by Mincer, we find that the empirical results are consistent with human capital theory. We find that,
although the positive relationship between earnings and experience persists when individual productivity measures are included
in the salary equations for lecturers and senior lecturers, the positive relationship becomes statistically insignificant
when the same productivity measures are included in the salary equations for professors. For lecturers and senior lecturers,
the experience-salary profile properly reflects the structure of the national pay scale rather than variations in individual
research productivity. At the professor level, where individual salaries are not determined by a pay scale, the data support
the human capital explanation of the positive experience-earnings profile.
相似文献
Robert J. NewmanEmail: |
84.
Morris RJ 《Journal of homosexuality》2006,51(3):225-247
In the long history of the West's encounter with Hawaiian culture, which began in the late 1700s with Captain Cook, translators and translations have often been the tools of intentional falsehood, thus demonstrating the truth of the Italian proverb, Traduttore, traditore ("the translator is a traitor")--particularly with regard to same-sex texts. The standards of truth have often been subverted in translation by the demands of foreign religion, hegemony, business, and academe. This subversion continues to this day in the form of the "missionary mentality" in politics and law. The way out of this situation is a brutally honest cleaning-off of the besmirched Hawaiian texts. 相似文献
85.
Klitzman R 《Journal of homosexuality》2006,51(3):7-32
Use of MDMA and other club drugs has increased among gay men, but questions remain concerning the use, context, and popularity of these drugs; and views of their side effects. We interviewed in-depth 12 gay MDMA users in New York. MDMA had specific appeals to gay men, who often described isolation and stigmatization. Users underwent a period of initiation and social networks often became comprised of greater numbers of other users. Club environments fostered drug use and vice versa. Awareness of potential adverse effects varied and was minimized. Appropriate educational and prevention programs are needed to address these issues, and must take into account the specific contexts of these gay men's lives. 相似文献
86.
Robert E. Wright 《LABOUR》1994,8(2):239-258
ABSTRACT This paper examines empirically the relationship between single-parenthood and absolute poverty in Great Britain. Data from two years of the Family Expenditure Survey are used (1968 and 1986). A poverty measure that is additively decomposable with population share weights, and consistent with Sen's axiomatic approach to poverty measurement, is used to decompose the total amount of poverty into the “shares” accruing to different types of households (i.e. female and male single-parents, two-parent households and “other” types of households). Three main conclusions concerning the poverty experience of British single-parents emerge from the analysis. The first is that poverty rates for single-parent households are generally higher than the average for all households. However, this disadvantage is not as large as one might expect, especially when a comparison is made with two-parent households. The second is that single-parent households are over-represented in the ranks of the poor. That is, their “share” of total poverty is greater than their population share. The third is that increasing single-parenthood has had little impact on the overall trend in absolute poverty in the period 1968 to 1986. 相似文献
87.
88.
The purpose of this study is to examine the reliability of the skin tone measures in the widely used American National Election Studies data collection (AN 相似文献
89.
Colin Thirtle David Hadley Robert Townsend 《Development policy review : the journal of the Overseas Development Institute》1995,13(4):323-348
To meet the [African] crisis one must turn to agricultural-led growth. But, based on historical experience, an agricultural-led strategy must be framed in no less than a twenty-year horizon and must entail a combination of technological innovation, policy reform, and institutional restructuring because each, by itself, is limited. (Eicher, 1989) 相似文献
90.
Abigail R. Smith Nathan P. Goodrich Charlotte A. Beil Qian Liu Robert M. Merion Brenda W. Gillespie 《Journal of applied statistics》2019,46(9):1702-1713
Graphical representation of survival curves is often used to illustrate associations between exposures and time-to-event outcomes. However, when exposures are time-dependent, calculation of survival probabilities is not straightforward. Our aim was to develop a method to estimate time-dependent survival probabilities and represent them graphically. Cox models with time-dependent indicators to represent state changes were fitted, and survival probabilities were plotted using pre-specified times of state changes. Time-varying hazard ratios for the state change were also explored. The method was applied to data from the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL). Survival curves showing a ‘split’ at a pre-specified time t allow for the qualitative comparison of survival probabilities between patients with similar baseline covariates who do and do not experience a state change at time t. Time since state change interactions can be visually represented to reflect changing hazard ratios over time. A2ALL study results showed differences in survival probabilities among those who did not receive a transplant, received a living donor transplant, and received a deceased donor transplant. These graphical representations of survival curves with time-dependent indicators improve upon previous methods and allow for clinically meaningful interpretation. 相似文献