A combined p-value test for multiple hypothesis testing

Tests that combine p-values, such as Fisher's product test, are popular to test the global null hypothesis H₀ that each of n component null hypotheses, H₁,…,H_n, is true versus the alternative that at least one of H₁,…,H_n is false, since they are more powerful than classical multiple tests such as the Bonferroni test and the Simes tests. Recent modifications of Fisher's product test, popular in the analysis of large scale genetic studies include the truncated product method (TPM) of Zaykin et al. (2002), the rank truncated product (RTP) test of Dudbridge and Koeleman (2003) and more recently, a permutation based test—the adaptive rank truncated product (ARTP) method of Yu et al. (2009). The TPM and RTP methods require users' specification of a truncation point. The ARTP method improves the performance of the RTP method by optimizing selection of the truncation point over a set of pre-specified candidate points. In this paper we extend the ARTP by proposing to use all the possible truncation points {1,…,n} as the candidate truncation points. Furthermore, we derive the theoretical probability distribution of the test statistic under the global null hypothesis H₀. Simulations are conducted to compare the performance of the proposed test with the Bonferroni test, the Simes test, the RTP test, and Fisher's product test. The simulation results show that the proposed test has higher power than the Bonferroni test and the Simes test, as well as the RTP method. It is also significantly more powerful than Fisher's product test when the number of truly false hypotheses is small relative to the total number of hypotheses, and has comparable power to Fisher's product test otherwise.     

The Theory Circle: A Tool for Learning and for Practice

Social workers have grappled for many years now with the tension between theory and practice. The struggle may be to bridge a perceived gap between the academic knowledge base of social work and the complex realities of practice. Equally, it may be to move from common‐sense interpretations of human need and professional responses, towards a more informed and accountable approach to practice. In recognition of the challenges faced by social work academics, practitioners and students, in relation to applying theory to practice, two of the authors of this paper developed a model, which aimed to facilitate productive discussions between practice teachers and students about the nature of theory and its link to practice. In addition, the model was designed to promote partnership approaches where service users participate fully in identifying their own issues and in shaping the services they receive. This paper describes the model—The Theory Circle—and reflects upon its effectiveness, based on the views of 19 practice teachers from central Scotland. The findings suggest that the pictorial model is one that practice teachers and students find accessible and valuable; it helps them to build a theoretical understanding of service users' situations and to work alongside service users to agree the most appropriate methods of intervention.     

A New Course Model for Content on Women's Issues in Social Work Education

This paper describes both the process of developing a new course on women and the content of such a course. Four issues that arose in introducing the course are critically examined: separation versus integration of course content; sexism versus racism; intellectual versus experiential learning; and women only versus coeducational enrollment. Throughout the paper, comparisons are made between basic tenets of social work practice and the women's movement. The paper concludes by speculating on the relationship between social work education and social movements in general.     

The Implementation of Mental Health Evidence Based Practices from the Educator,Clinician and Researcher Perspective

Within the different arenas of social work practice, community based mental health is among the most advanced in terms of defining a set of evidence based practices (EBPs). Social workers play a major role in the delivery of community based mental health and are at the forefront of efforts to implement these practices through state and federal initiatives. One such initiative is The New York Office of Mental Health Evidence Based Project, which is designed to increase the knowledge and skills related to evidence-based practice among New York’s mental health human services workforce. The project had a social work component, which trained students in implementing EBP’s through specially designed curricula and field placements. The students participating in the project encountered numerous challenges in the field including lack of agency “buy-in” and infrastructure support; inadequate training and resources; poor supervision; and provider resistance. From the multilevel perspectives of educator, clinician and researcher, this paper addresses these challenges and makes recommendations to facilitate the implementation of EBPs.     

Work-Life Balance: A Case of Technical Disempowerment?

Work–life balance (WLB) is an emblematic strategy to achievewell-being for Third Way governments around the world and anexercise in nurturing self-actualizing and entrepreneurial citizens.By reading a case study of New Zealand's Labour WLB projectthrough a poststructuralist perspective, I demonstrate thatThird Way WLB policy projects are technical exercises in ethicalization.These practices serve to de-contextualize and de-politicizethe terrain of well-being. This analysis highlights a contradictionin Third Way agendas to address the well-being of the needybecause they disempower those they seek to empower.     

Housing strategies in an uncertain market

The slump in house prices in the early 1990s created a degree of uncertainty in the housing market which contrasts markedly with the optimism of the 1980s. In particular, the market downturn made it sharply apparent that there could be losers as well as winners in the unstable housing market. This study looks at a sample of owner occupiers drawn from Glasgow and Bristol in 1995. While still endorsing home ownership as the major housing option and as potentially enabling in housing and neighbourhood terms, a note of caution is recognisable. Aspirations to climb the housing ‘ladder’ are tempered by fear of overextending financially and by the broader uncertainties that people perceive to be endemic in the labour market and the housing market. Strategies reflect both diverse personal histories and the adoption of defensive or risk reduction options. For many respondents maintaining current housing standards is more important than market advancement.     

Second‐Generation Poverty Reduction Strategies: New Opportunities and Emerging Issues

The poverty reduction strategy paper (PRSP) approach has taken centre stage in development asssistance over the past five years. International endorsement of the approach has led to important gains in government focus on poverty reduction, civil society participation and donor behaviour. Yet PRSPs also potentially offer a much greater contribution to aid effectiveness, good governance and poverty reduction in developing countries. With a second generation of PRSPs now set to appear, this article examines the technical and political challenges that need addressing to realise their potential over time. Emerging issues include how to respond to political transitions, alternative design approaches, how to assess financing needs, and ways of enhancing the predictability of aid.