Shape properties of the g-and-h and johnson families

A substantial part of examining the properties of a distributional family consists of considering shape properties. It is important that this examination is sufficiently thorough to enable understanding of the behaviour of the family, its comparison with others, and to assist in developing future families. The g-and-h distributions and the Johnson system are examined here in these terms     

Three-stage designs for monitoring clinical trials

Optimal three-stage designs with equal sample sizes at each stage are presented and compared to fixed sample designs, fully sequential designs, designs restricted to use the fixed sample critical value at the final stage, and to modifications of other group sequential designs previously proposed in the literature. Typically, the greatest savings realized with interim analyses are obtained by the first interim look. More than 50% of the savings possible with a fully sequential design can be realized with a simple two-stage design. Three-stage designs can realize as much as 75% of the possible savings. Without much loss in efficiency, the designs can be modified so that the critical value at the final stage equals the usual fixed sample value while maintaining the overall level of significance, alleviating some potential confusion should a final stage be necessary. Some common group sequential designs, modified to allow early acceptance of the null hypothesis, are shown to be nearly optimal in some settings while performing poorly in others. An example is given to illustrate the use of several three-stage plans in the design of clinical trials.     

On L 1-consistency of kernel-type density estimator for stationary markov processes

A convergence result for kernel type density estimators, proved by Devroye and Gyrofi (1985), is extended to stationary Markov processess satisfying (G ₂-condition introduced by Rosenblatt (1970).     

Inflated modified power series distributions with applications

In certain applications involving discrete data, it is sometimes found that X = 0 is observed with a frequency significantly higher than predicted by the assumed model. Zero inflated Poisson, binomial and negative binomial models have been employed in some clinical trials and in some regression analysis problems.

In this paper, we study the zero inflated modified power series distributions (IMPSD) which include among others the generalized Poisson and the generalized negative binomial distributions and hence the Poisson, binomial and negative binomial distributions. The structural properties along with the distribution of the sum of independent IMPSD variables are studied. The maximum likelihood estimation of the parameters of the model is examined and the variance-covariance matrix of the estimators is obtained. Finally, examples are presented for the generalized Poisson distribution to illustrate the results.     

Sample design for observing classes of objects

We consider optimal sample designs for observing classes of objects. Suppose we will take a simple random sample of equal-sized sectors from a study population and observe the classes existing on these sectors. The classes might be many different things, for example, herbaceous plant species (in sampling quadrats), microinvertebrate species (in sampling cores), and side effects from a drug (in conducting medical trials). Under a nonparametric mixture model and data from a previous related study, we first estimate the optimal number of sample sectors of a given size. Then for negative binomial dispersions of individuals with a common aggregation parameter k, we consider the optimal size as well as number of sample sectors. A simple test exists to check our common k assumption and our optimal size method requires far less data than would be required by a grid method or other method which utilizes data from sample sectors of several different sizes.     

Exact permutation inference for two sample repeated measures data

Experiments in which very few units are measured many times sometimes present particular difficulties. Interest often centers on simple location shifts between two treatment groups, but appropriate modeling of the error distribution can be challenging. For example, normality may be difficult to verify, or a single transformation stabilizing variance or improving normality for all units and all measurements may not exist. We propose an analysis of two sample repeated measures data based on the permutation distribution of units. This provides a distribution free alternative to standard analyses. The analysis includes testing, estimation and confidence intervals. By assuming a certain structure in the location shift model, the dimension of the problem is reduced by analyzing linear combinations of the marginal statistics. Recently proposed algorithms for computation of two sample permutation distributions, require only a few seconds for experiments having as many as 100 units and any number of repeated measures. The test has high asymptotic efficiency and good power with respect to tests based on the normal distribution. Since the computational burden is minimal, approximation of the permutation distribution is unnecessary.     

A note on second order slope rotatable designs over all directions

Hader and Park (1978) introduced second order slope rotatability in axial directions. Park (1987) introduced second order slope rotatabilty over all directions. It is shown that these designs have the additional properly that the sum of the variances of estimates of slopes in all directions at any point is a function of the distance of the point from the design origin.     

Estimation of gaussian mixtures with rotationally invariant covariance matrices

Homoscedastic and heteroscedastic Gaussian mixtures differ in the constraints placed on the covariance matrices of the mixture components. A new mixture, called herein a strophoscedastic mixture, is defined by a new constraint, This constraint requires the matrices to be identical under orthogonal trans¬formations, where different transformations are allowed for different matrices. It is shown that the M-step of the EM method for estimating the parameters of strophoscedastic mixtures from sample data is explicitly solvable using singular value decompositions. Consequently, the EM-based maximum likelihood estimation algorithm is as easily implemented for strophoscedastic mixtures as it is for homoscedastic and heteroscedastic mixtures. An example of a “noisy” Archimedian spiral is presented.     

Umvu estimators for the population mean and variance based on random effects models for lognormal data

Cross-classified data are often obtained in controlled experimental situations and in epidemiologic studies. As an example of the latter, occupational health studies sometimes require personal exposure measurements on a random sample of workers from one or more job groups, in one or more plant locations, on several different sampling dates. Because the marginal distributions of exposure data from such studies are generally right-skewed and well-approximated as lognormal, researchers in this area often consider the use of ANOVA models after a logarithmic transformation. While it is then of interest to estimate original-scale population parameters (e.g., the overall mean and variance), standard candidates such as maximum likelihood estimators (MLEs) can be unstable and highly biased. Uniformly minimum variance unbiased (UMVU) cstiniators offer a viable alternative, and are adaptable to sampling schemes that are typiral of experimental or epidemiologic studies. In this paper, we provide UMVU estimators for the mean and variance under two random effects ANOVA models for logtransformed data. We illustrate substantial mean squared error gains relative to the MLE when estimating the mean under a one-way classification. We illustrate that the results can readily be extended to encompass a useful class of purely random effects models, provided that the study data are balanced.     

The effects of covariate adjustment in generalized linear models

Results from classical linear regression regarding the effects of covariate adjustment, with respect to the issues of confounding, the precision with which an exposure effect can be estimated, and the efficiency of hypothesis tests for no treatment effect in randomized experiments, are often assumed to apply more generally to other types of regression models. In this paper results pertaining to several generalized linear models involving a dichotomous response variable are given, demonstrating that with respect to the issues of confounding and precision, for models having a linear or log link function the results of classical linear regression do generally apply, whereas for other models, including those having a logit, probit, log-log, complementary log-log, or generalized logistic link function, the results of classical linear regression do not always apply. It is also shown, however, that for any link function, covariate adjustment results in improved efficiency of hypothesis tests for no treatment effect in randomized experiments, and hence that the classical linear regression results regarding efficiency do apply for all models having a dichotomous response variable.